An Overview of the Pharmacological Studies and Clinical Applications of Chai Hu in Digestive Diseases

Authors

  • Chen Li Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Hui Ding Shaanxi Provincial Hospital of Chinese Medicine, Xi'an 710003, Shaanxi, China

DOI:

https://doi.org/10.53469/jcmp.2024.06(11).36

Keywords:

Chai Hu, Pharmacological effect, Diseases of the digestive system, Literature review

Abstract

Chaihu was first published in Shennong's Classic of the Materia Medica, and has been used in China for more than 2,000 years. It is derived from the Umbelliferae Buplueurum Chinese DC or Buplueurum scorzonerifolium Willd. Chaihu is distributed in many parts of China with rich output, among which Shaanxi, Shanxi, Gansu, Guizhou, Sichuan, Hebei, Henan, Hubei and other places as the main producing areas. Chaihu has a long history of application and is one of the oldest and most commonly use Chinese herbal medicine, with high medicinal value. Modern pharmacological studies have found that Chaihu has the ability to protect the liver, protect the gastric mucosa, enhance gastrointestinal motility, inhibit intestinal inflammation, anti-ulcer and other effects. Clinically, Chai Hu and Formulas with Chai Hu as the main herb are widely used in the treatment of digestive disorders, and their efficacy is remarkable. This paper presents a literature review of previous pharmacological studies and clinical applications of Chai Hu in digestive disorders, with the aim of providing a reference for better research on Chai Hu and its applications in clinical practice.

References

LI Yanfeng, LIU Yashu, LI Yansheng. Progress in the study of chemical composition and pharmacological effects of Chai Hu [J]. Northwest Journal of Pharmacy, 2022, 37(5): 186-192.

YANG Qiang, YU Huan, GONG Qianfeng. Historical evolution and modern research on the concoction of Chaihu [J]. Journal of Jiangxi University of Traditional Chinese Medicine, 2017, 29(4): 121-124.

HE Yan, HU Zhifeng, LI Ping, et al. Study on the anti-lipid peroxidation effect of Chaihu saponin d in rats with liver fibrosis [J]. Chinese Journal of Traditional Chinese Medicine, 2008(8): 915-919.

Zhu Y, Chen X, Rao X, et al. Saikosaponin a ameliorates lipopolysaccharide and dgalactosam ine-induced liver injury via activating lxrα [J]. International Immunopharmacology, 2019 (72): 131 –137.

Chen Y, Que R, Lin L, et al. Inhibition of oxidative stress and nlrp3 inflammasome by saikosaponin-d alleviates acute liver injury in carbon tetrachloride-induced hepatitis in mice [J]. International Journal of Immunopathology and Pharmacology, 2020 (34): 1–11.

Sun Xiaobo. Protective effect of chaihu polysaccharide on experimental gastric mucosal injury [J]. Jilin Chinese Medicine, 1991(6): 33-34.

WANG Shuai, BAO Yongrui, MENG Xiansheng, et al. Protective effect of Chaihu saponin on gastric mucosal damage caused by anhydrous ethanol [J]. Chinese Journal of Experimental Formulas, 2013, 19(8): 191-194.

Li Yan, Chen Suning, Chen Shaofu, et al. Effects of Chaihu Hovenbergia sinensis on gastric emptying, small intestinal propulsive function and blood levels of gastric actin and gastrin in healthy subjects [J]. Chinese Journal of Integrative Medicine, 1996(10): 622.

WANG Xiaonan, GAO Peng, LIU Wenjuan, et al. Current status of the application of Chaihu in digestive system diseases [J]. China Modern Drug Application, 2008(20): 114-115.

Zhou F, Wang N, Yang L, et al. Saikosaponin a protects against dextran sulfate sodium-induced colitis in mice [J]. International Immunopharmacology, 2019(72): 454–458.

Ma Haiyan, Ma Yukui. Study on the therapeutic effect of Chaihu saponin on gastric ulcer [J]. Qilu Medicine, 2011, 30(6): 318-319.

He Lingbing, Bao Yongrui, Wang Shuai, et al. Pharmacokinetic-pharmacodynamic correlations based on the anti-ulcer pharmacodynamic components of Chaihu saponin [J]. Chinese Journal of Experimental Formulary, 2017, 23(10): 73-78.

Wang Kai. Clinical observation on the treatment of liver-stomach disharmony-type gastroesophageal reflux disease by adding Xiao-chaihu Tang [D/OL]. Guangxi University of Traditional Chinese Medicine, 2021. 000137.

Niu Hongbin. Clinical observation on the treatment of gastroesophageal reflux disease with the addition and subtraction of Chaihu Shuohe San [J]. Electronic Journal of Cardiovascular Diseases of Chinese and Western Medicine, 2020,8(28): 147-149.

MIAO Pu, WANG Hongbai, GUO Feng. Analysis of the effect of applying Xiao Chaihu Tang in the treatment of bile reflux gastritis [J]. Systemic medicine, 2021, 6(18): 152-154.

Chen Liansheng. Observation on the effect of adding and subtracting Chaihu Shunhe Tang in treating patients with chronic atrophic gastritis with liver and stomach disharmony evidence [J]. Henan Medical Research, 2018,27(5): 907-908.

Wang ZL. Clinical observation on the therapeutic effect of Da Chai Hu Tang on gastric ulcer [J]. Chinese Journal of Integrative Medicine of Spleen and Stomach, 1994(3): 5-7.

Wang Fei. Clinical study on the treatment of peptic ulcer by adding and subtracting Xiao Chaihu Tang [J]. Henan Traditional Chinese Medicine, 2014, 34(4): 589-590.

Huang Fenqiang. Discussion on the effect of Chaihu Shao Yao Tang plus and minus formula in the treatment of ulcerative colitis [J]. Contemporary Medicine Series, 2019, 17(16): 210-212.

Li Renfeng. Effectiveness of Chaihu Shuo Liver Relief Tang in treating functional dyspepsia of liver-qi stagnation type [J]. China Medical Guide, 2020, 18(35): 148-149.

Jiang Haisong. Clinical effect of Chai Hu Gui Zhi Gan Jiang Tang in treating diarrhea-type irritable bowel syndrome with liver depression and spleen deficiency [J]. Research on Chinese and Foreign Medicine, 2022, 20(7): 10-14.

Yan Zhaoping, Huang Wenfu, Wei Xiangyang, et al. Treatment of 33 cases of functional gastrointestinal diseases with Chai Hu plus Long Bone Oyster Soup [J]. Modern Journal of Integrative Medicine, 2010, 19(22): 2799-2800.

Downloads

Published

2024-11-28

How to Cite

Li, C., & Ding, H. (2024). An Overview of the Pharmacological Studies and Clinical Applications of Chai Hu in Digestive Diseases. Journal of Contemporary Medical Practice, 6(11), 178–181. https://doi.org/10.53469/jcmp.2024.06(11).36