Journal of Contemporary Medical Practice
Editor-in-Chief: Dr. Serkan TURSUN ISSN: 2006-2745 Frequency: Monthly Submit Email: jcmp@bryanhousepub.org APC: $300 Journal of Contemporary Medical Practice (JCMP) is an initiative to encourage researchers, clinicians and individuals to share research advances the field of addiction medicine. The Journal of Contemporary Medical Practice is a unique platform that publishes current findings in science and medicine and promotes health and wellness. The editorial board of JCMP is a committed team of experts that ensures quality publishing of complete and reliable sources of information on discoveries and current developments in the field of Contemporary Medical Practice. It is a scientific, internationally refereed journal that publishes retrospective / prospective clinical and laboratory studies, interesting case presentations, invited collections, editorial letters, original images, short reports and surgical technical articles about every branch of medicine.
Research Progress on the Integrated Traditional Chinese and Western Medicine Therapy for Cancer-Related Anemia
Cancer-related anemia (CRA) is a common complication in patients with malignant tumors, which not only affects their quality of life but may also reduce the efficacy and tolerance of radiotherapy and chemotherapy. In recent years, integrated Traditional Chinese and Western medicine (TCM-WM) has demonstrated unique advantages in treating CRA. Modern medicine primarily employs therapies such as erythropoietin, iron supplementation, and blood transfusion, which have limitations and potential risks. Traditional Chinese Medicine (TCM), through treatment approaches like fortifying the spleen and nourishing the kidney, replenishing qi and blood, and activating blood circulation to remove stasis, improves the hematopoietic microenvironment and regulates the body’s immune function, showing increasing promise in recent years. By combining the strengths of both systems, integrated TCM-WM exhibits synergistic effects in elevating hemoglobin levels, improving clinical symptoms, reducing side effects of Western medical treatments, and enhancing the quality of life. Current research confirms its safety and efficacy; however, more high-quality, large-sample clinical studies are needed in the future to further explore its mechanisms of action and optimize diagnosis and treatment protocols.
Copyright (c) 2025 Yaoqi Wen, Yanli Zhao, Liangliang Li, Yupei Wang https://creativecommons.org/licenses/by-nd/4.0
Exploring Acupuncture-Mediated Gut Microbiota Regulation for Post-PCI Depression in Coronary Heart Disease Based on the “Heart Corresponding to the Small Intestine” Theory
The incidence of depression significantly elevates in coronary heart disease (CHD) patients after percutaneous coronary intervention (PCI), a condition pathologically linked to disruptions in the gut microbiota-mediated “gut-heart-brain axis. This phenomenon has emerged as a critical risk factor impeding postoperative recovery. Grounded in the core principle of visceral synergy from the traditional Chinese medicine (TCM) theory of “heart-small intestine interconnection, this study integrates evidence from both Chinese and Western medical research to systematically investigate the mechanisms underlying acupuncture’s regulation of gut microbiota and its therapeutic value for dual-heart diseases. This synergistic “treating heart via regulating intestine” effect provides a modern microbiological interpretation of visceral theory within the microbiota-gut-brain framework and establishes the scientific basis for acupuncture in managing post-PCI depression. Our findings offer theoretical support for integrated Chinese-Western treatment strategies and highlight acupuncture’s unique advantage in multi-target modulation.
Copyright (c) 2025 Yunlin Zhang, Ruijie Xu, Dongmin Liu https://creativecommons.org/licenses/by-nd/4.0
Research Progress on the Effect of Circadian Rhythm Disruption on the Pathogenesis of Chronic Atrophic Gastritis
The circadian rhythm, as a crucial endogenous regulatory mechanism for organisms to adapt to periodic changes in the external environment, is closely related to the occurrence and development of various digestive system diseases when disrupted. Recent studies have found that patients with chronic atrophic gastritis (CAG) commonly exhibit manifestations of circadian rhythm disruption such as sleep disorders and irregular meal times, suggesting that abnormalities in clock genes may participate in the pathological process of CAG by regulating the rhythm of gastric acid secretion, gastric mucosal barrier repair, and inflammatory response pathways. Aberrant expression of core clock genes BMAL1 and CLOCK can disrupt the balance between gastric epithelial cell proliferation and apoptosis, while disrupted melatonin secretion may exacerbate oxidative stress damage to the gastric mucosa. Animal experiments have confirmed that long-term alterations in the light-dark cycle or knockout of clock genes can induce gastric mucosal atrophy and intestinal metaplasia, with the activation of signaling pathways such as NF-κB and MAPK playing a key role in this process. Clinical studies further reveal a significantly higher incidence of CAG among shift workers, showing a dose-response relationship with abnormalities in rhythm-related hormone levels. Current evidence supporting the application of rhythm interventions, such as timed feeding and light therapy, in the prevention and treatment of CAG requires further high-quality validation. Future research needs to deeply explore mechanisms such as the epigenetic regulation of clock genes and the microbiota-circadian axis interaction to provide a theoretical basis for developing chronotherapy-based strategies for CAG prevention and treatment.
Copyright (c) 2025 Ya Ding, Hui Ding https://creativecommons.org/licenses/by-nd/4.0
Research Advances in Integrating Traditional Chinese and Western Medicine for Chronic Renal Failure
Chronic renal failure represents the ultimate outcome of various kidney diseases. Clinically, treatment approaches for this condition are categorized into Western and Traditional Chinese Medicine (TCM) methods. This study will systematically review Western medical diagnostic and therapeutic approaches, alongside traditional Chinese medicine perspectives on pathogenesis, syndrome differentiation, treatment modalities, and integrated approaches. It will summarize commonly used Western medications for chronic renal failure alongside clinical applications of Chinese herbal extracts, formulas, and external therapies. By synthesizing prior research, this work aims to clarify the advantages of integrated medicine, offering additional clinical guidance and insights.
Copyright (c) 2025 Chenrui Wang, Yanlong Zhao https://creativecommons.org/licenses/by-nd/4.0
Research Progress on Comprehensive Traditional Chinese Medicine Therapy for Lumbar Disc Herniation in the Past Decade
In recent years, with the acceleration of the pace of life, poor lifestyle habits have led to a gradual increase in the incidence of lumbar disc herniation (LDH), with a trend towards younger age groups, resulting in a significant social burden. However, conservative treatments face challenges such as considerable individual variability in efficacy and the need for repeated medical visits, which can lead to poor patient compliance. Traditional Chinese medicine (TCM) offers a variety of external therapies for LDH, including acupuncture, tuina (therapeutic massage), herbal plasters, fumigation, moxibustion, and their combinations. These therapies collectively contribute to reducing inflammatory factor levels, alleviating tissue adhesions, improving lumbar function, decreasing lumbar fibrosis, enhancing neuroelectrophysiological function, and lowering recurrence rates. In clinical practice, multiple TCM therapies are often combined to address both the symptoms and root causes of the disease. Through literature review, this paper summarizes the research progress on comprehensive TCM therapies for LDH over the past decade, aiming to provide references for current TCM treatment methods and research mechanisms related to LDH.
Copyright (c) 2025 Yunqing Zhang, Xuefeng Cai, Xiaofeng Shen https://creativecommons.org/licenses/by-nd/4.0
Modern Clinical Applications and Scientific Research Progress of Ashi Points in Multiple Fields
Ashi points, as an important concept in acupuncture therapy, have evolved from the traditional theory of “using pain as the acupoint” to a widely applied treatment method in various clinical fields. This article systematically reviews the current status of clinical application of Ashi points in pain management, musculoskeletal disorders, gynecological diseases, digestive system diseases, and other fields, and explores their mechanisms of action in conjunction with modern scientific research. Clinical studies have shown that acupuncture at Ashi points demonstrates superior efficacy compared to conventional acupoint acupuncture in treating conditions such as lumbar myofascial pain syndrome. Among these, the randomized controlled trial by Huang Sufang et al. showed that acupuncture at Ashi points can significantly improve the morphology and function of the multifidus muscle, eliminate muscle nodules, and increase pressure pain thresholds. Concurrently, modern technologies such as Quantitative Sensory Testing (QST) and ultrasound imaging provide new methods for the objective diagnosis and treatment of Ashi points. By measuring temperature thresholds and pressure pain thresholds, the pathological characteristics of “cold, heat, deficiency, and excess” of Ashi points can be identified, enabling precise treatment selection. This article also analyzes the existing misunderstandings in the conceptual understanding of Ashi points, pointing out the limitations of simplistically interpreting “Ashi” as the patient’s exclamation of pain or viewing it solely as a tender point. It emphasizes the multiple meanings contained in the term “kuai ran”, including comfort and relief. Finally, the paper proposes advancing the modernization of Ashi point research from three aspects: precision in treatment selection, objectivity in efficacy evaluation, and differentiation in mechanism studies, providing new research directions for the scientific development of Traditional Chinese Medicine (TCM) acupuncture.
Copyright (c) 2025 Zhaopeng Wang, Jianwei Zhang https://creativecommons.org/licenses/by-nd/4.0
Experience of Traditional Chinese Medicine Master Lei Zhongyi in Treating Heart Diseases
Professor Lei Zhongyi, as a third-generation master of traditional Chinese medicine, has cultivated profound expertise in the field of cardiovascular diseases in traditional Chinese medicine for over sixty years. The core innovation of his academic thought lies in proposing the new viewpoint of “treating chest pain from the perspective of phlegm and blood stasis,” breaking through the limitations of the previous approach of simply treating it from the perspective of blood stasis or phlegm turbidity [1]. In clinical practice, he skillfully uses modified Gualou Xiebai Decoction, Danlou Decoction, and his self-created Yangxin Huoxue Decoction, flexibly adapting them to the diagnosis and treatment of coronary heart disease, heart failure, and various arrhythmias, achieving remarkable therapeutic effect [2]. Simultaneously, his achievements in the modern research and development of the herb Yanghongshan have been outstanding, verifying the scientific validity of the theory of “treating the heart from the kidneys” [3]. This article systematically reviews Professor Lei Zhongyi’s theoretical innovations, diagnostic thinking, application of classic prescriptions, and experience in adjusting prescriptions according to symptoms in the diagnosis and treatment of cardiovascular diseases, aiming to provide important reference for the clinical practice and research of cardiovascular diseases in traditional Chinese medicine.
Copyright (c) 2025 Yangyang Yan, Xinbing Wang, Tuowei Zhang https://creativecommons.org/licenses/by-nd/4.0
Research Progress on the Treatment of Ulcerative Colitis with Shenling Baizhu Powder
Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized by recurrence, difficulty in curing, and the risk of accelerated colon cancer. Shenling Baizhu Powder, from “Prescriptions People’s Welfare Pharmacy”, is a classic prescription for treating diarrhea of spleen deficiency and dampness accumulation type, with the core therapeutic principle of “tonifying qi and strengthening the spleen, removing dampness and stopping diarrhea”, and is a commonly used prescription for treating UC. Through a multi-dimensional review of the clinical research and mechanism of action of Shenling Baizhu Powder for the treatment of UC, it is concluded that Shenling Baizhu Powder can be applied through the original formula, combined with Western medicine, compound, etc. In regulating gut microbiota, promoting tight junctions between intestinal epithelium, promoting mucin secretion, regulating immune response, alleviating oxidative stress, regulating water metabolism, inhibiting Toll-like receptor-4 (TLR4)/pro-inflammatory transcription factor nuclear transcription factor-KB (NF-κB), TLR-5/myeloid differentiation factor (MyD88)/NF-KB, β2-epinephrine The receptor (β2AR)/arrestin2/NF-κB signaling pathways act, providing a theoretical basis for the clinical application of Shenling Baizhu Powder in the treatment of UC.
Copyright (c) 2025 Xiaolin Liu, Li Liu, Xiaobing Ma https://creativecommons.org/licenses/by-nd/4.0
Exploring the Treatment of Cognitive Impairment with Depression from the Perspective of Regulating Qi and Restoring Mental Function under the Theory of “Qi Monism”
Based on the philosophical foundation of Traditional Chinese Medicine (TCM) known as “Qi monism,” this paper systematically explores the clinical application value of the theory of ascending and descending Qi in Cognitive Impairment with Depression (CID). By reviewing classical medical texts and modern research, we analyze the intrinsic relationship between the etiology and pathogenesis of CID and dysregulation of Qi movement. A three-dimensional treatment model—centered on the “Middle Jiao as Pivot, Liver-Lung as Peripheral Wheel, Heart-Kidney as Root”—is proposed to establish a syndrome differentiation and treatment system, offering new therapeutic insights for clinical practice.
Copyright (c) 2025 Yutong Nan, Zucheng Han https://creativecommons.org/licenses/by-nd/4.0
Research Progress on Traditional Chinese Medicine in Alzheimer’s Disease via Intervention in Apoptosis
Neurodegenerative diseases (AD, PD, HD, ALS) share the common pathological endpoint of “irreversible neuronal loss,” with apoptosis serving as the “terminal common pathway” driving disease progression. Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder characterized primarily by the gradual deterioration of cognitive and memory functions. Its pathological hallmarks include neurofibrillary tangles formed by aggregates of hyperphosphorylated microtubule-associated protein (Tau) and amyloid plaques resulting from β-amyloid protein aggregation. The exact pathogenesis of AD remains incompletely understood, and there are currently no effective disease-modifying treatments or curative approaches available in clinical practice. In recent years, the incidence of AD has shown an increasing trend, significantly impacting public health and quality of life. Therefore, identifying effective therapeutic agents and compounds for AD is of paramount importance. Neuronal loss in Alzheimer’s disease is not merely a result of Aβ or Tau “toxic proteins” directly killing cells. Rather, it is the consequence of “programmed cellular suicide” induced by the persistent activation of apoptotic signaling networks by these agents. Modern medical research has revealed that intervening in apoptosis plays a crucial role in the pathophysiological development of AD. Furthermore, traditional Chinese medicine (TCM) has a long history of application in treating neurodegenerative diseases, offering advantages such as fewer adverse effects and the characteristic of multi-target, multi-link, and multi-pathway intervention. Consequently, based on reviewing and analyzing the latest domestic and international research, this article elaborates on the role of apoptosis in the onset and progression of AD and summarizes recent advances in TCM interventions targeting apoptotic pathways for AD treatment. The aim is to provide references and a foundation for developing clinical drugs to prevent and treat AD and to offer a broader perspective on the potential of TCM in managing this condition.
Copyright (c) 2025 Chunman Zhou, Shiyao Zhang, Hui Wang https://creativecommons.org/licenses/by-nd/4.0
Discussion on the Etiology and Pathogenesis of Eczema from the Perspective of Zangxiang Theory
Wet eczema corresponds to eczema in Western medicine and represents one of the most common and challenging conditions in dermatology. It is characterized by recurrence, pruritus, exudation, symmetry, polymorphic lesions, and a tendency toward chronicity. Western medical treatment primarily relies on corticosteroids and antihistamines, but therapeutic effects are inconsistent, and significant adverse reactions often occur after discontinuation of corticosteroids. Therefore, compared with Western medical treatment, TCM syndrome differentiation treatment offers distinct characteristics and advantages. Taking the theory of Zangxiang as the main entry point, this paper explores the etiology and pathogenesis of wet eczema from the perspective of Zangxiang, aiming to better understand and treat eczema from the aspects of etiology and pathogenesis.
Copyright (c) 2025 Xi Li, Zhenlin Chen https://creativecommons.org/licenses/by-nd/4.0
Progress in Integrative Traditional Chinese and Western Medicine Treatment of Idiopathic Membranous Nephropathy
MN is a major cause of nephrotic syndrome in middle-aged and elderly patients. However, relevant studies have shown that it has exhibited a significant trend of younger onset in China in recent years. Among different types of MN, IMN is the primary cause of primary nephrotic syndrome in adults. Nevertheless, IMN is characterized by unknown etiology, high recurrence rate, and poor prognosis. This article summarizes and explores the integrative treatment of membranous nephropathy with traditional Chinese medicine (TCM) and Western medicine, aiming to provide better support for clinical practice in the treatment of membranous nephropathy.
Copyright (c) 2025 Hongchao Wang, Xinbo Yang https://creativecommons.org/licenses/by-nd/4.0
Overview of TCM Etiology, Pathogenesis and TCM Treatment of Chronic Obstructive Pulmonary Disease
The number of patients with Chronic Obstructive Pulmonary Disease (COPD) in China is nearly 100 million, and it has become the fourth leading cause of death in the country. At present, Western medicine has a variety of treatment methods for COPD, including oxygen therapy, antibiotics, glucocorticoids, and smoking cessation. However, due to the long course of the disease, long-term use of drugs may lead to drug resistance and adverse reactions, resulting in limitations in application, which still cannot meet the needs of solving clinical problems of COPD. Traditional Chinese Medicine (TCM) has unique advantages in the treatment of COPD, and has formed a series of prevention and treatment measures including “preventing disease before its onset”, “holistic concept”, and “treating the symptoms in acute phase and the root cause in stable phase”. This article reviews the etiology, TCM pathogenesis, and TCM treatment of COPD to further improve the management of such patients.
Copyright (c) 2025 Huimin Ren https://creativecommons.org/licenses/by-nd/4.0
Study on the Effects of Acupuncture in Alleviating Depression and Social Anxiety Induced by Chronic Pain in Patients
Objective: To investigate the efficacy of acupuncture in alleviating chronic pain, explore its relationship with depression and social anxiety in chronic pain patients, and clarify the therapeutic role of acupuncture. Methods: Between 2023 and July 2024, 126 patients were randomly selected from the acupuncture department of a traditional Chinese medicine hospital in Shaanxi Province. Questionnaires comprising the Numerical Rating Scale for Pain, Beck Depression Inventory (BDI), and Interpersonal Anxiety Scale (IAS) were administered. Results: Chronic pain severity positively correlated with depression (r = 0.218, P < 0.05), and depression positively correlated with social anxiety (r = 0.511, P < 0.05).The severity of chronic pain influenced an individual’s depression status (adjusted R²= 0.04, β = 1.039), while depression scores affected an individual’s social anxiety status (adjusted R²= 0.225, β = 0.404).Follow-up assessments indicated acupuncture’s impact on chronic pain, depression, and social anxiety, with the most pronounced effect on chronic pain and the least evident on social anxiety (chronic pain P=0.012, depression scores P=0.032, social anxiety P=0.046). Conclusion: Individuals with higher levels of chronic pain exhibited more severe depressive symptoms, and those with more severe depression also scored higher on social anxiety measures. Acupuncture treatment produced significant improvements in chronic pain, and as pain conditions improved during this process, patients’ depression and social anxiety also showed some degree of improvement.
Copyright (c) 2025 Chenhao Li, Yongfeng Li https://creativecommons.org/licenses/by-nd/4.0
Research on Pathogenesis and Management Strategies for Pediatric Allergic Purpura from Both Chinese and Western Medical Perspectives
Henoch-Schönlein purpura (HSP) is a common systemic vasculitis in children, affecting small blood vessels in the skin, musculoskeletal system, gastrointestinal tract, and kidneys. Its primary clinical manifestations include non-thrombocytopenic palpable purpura, arthritis or arthralgia, diffuse abdominal pain, and renal involvement characterized by hematuria and/or proteinuria. Approximately 20% to 80% of pediatric HSP patients develop renal damage, including hematuria and proteinuria. Furthermore, childhood HSP exhibits a high recurrence rate; frequent and prolonged episodes of rash recurrence increase the susceptibility to renal injury. Therefore, early intervention in pediatric HSP is crucial for improving prognosis. The pathogenesis of allergic purpura remains unclear in modern medicine. While various indicators for assessing disease severity and prognosis are well-established, treatment typically involves symptomatic management. No specific therapy currently exists, and treatments like corticosteroids, immunosuppression, and blood purification are reserved for severe HSP. Crucially, children are in a critical growth and development phase, and certain immunotherapies may cause severe immunosuppression, serious complications, and increased risks of infection and organ damage. With the continuous development and advancement of traditional Chinese medicine (TCM), new treatment options have emerged for pediatric HSP patients. Multiple studies indicate that TCM treatment for childhood HSP can reduce recurrence rates, achieving satisfactory outcomes in both efficacy and safety.
Copyright (c) 2025 Qiling Yin, Weihua Zhang https://creativecommons.org/licenses/by-nd/4.0
Research Progress on Common Protocols and Clinical Advantages of Acupuncture and Tuina Therapy for Peptic Ulcer
Peptic ulcer (PU) is a common digestive system disorder, primarily occurring in the stomach and duodenum. Its pathogenesis is closely related to factors such as auto-digestion by gastric acid and pepsin, Helicobacter pylori infection, use of non-steroidal anti-inflammatory drugs, and stress. Although modern medicine has made significant progress in acid suppression, gastric mucosal protection, and H. pylori eradication, it still faces challenges such as high recurrence rates and drug side effects. Acupuncture and tuina, as complementary and alternative therapies, are important components of non-pharmacological treatment in Traditional Chinese Medicine (TCM). They have accumulated extensive clinical experience in treating PU and possess unique advantages characterized by holistic treatment and a patient-centered approach. This paper aims to systematically review recent common protocols of acupuncture and tuina for PU (including acupoint selection principles, manipulation techniques, acupoint combination patterns, tuina techniques and targeted areas), and based on clinical research evidence, summarize their clinical advantages in alleviating symptoms, promoting ulcer healing, regulating overall bodily functions, reducing recurrence rates, and ensuring safety. The goal is to provide references for clinical practice and related research.
Copyright (c) 2025 Xiaowei Lu, Yumin Huang, Dan Wang https://creativecommons.org/licenses/by-nd/4.0
Correlation of Abnormal Cervical Proprioception with Visual-Vestibular Interaction Dysfunction in Cervicogenic Dizziness
Objective: To investigate the correlation between abnormal cervical proprioceptive input (joint position sense, JPS) and visual-vestibular interaction dysfunction in patients with cervicogenic dizziness (CV), providing objective evidence for the “sensory integration dysfunction” pathomechanism. Methods: A retrospective case-control study was conducted. Thirty-seven CV patients and 37 healthy controls were included. Objective data including cervical JPS error, key parameters of computerized dynamic posturography (CDP) sensory organization test (SOT) (primarily vestibular ratio and sensory integration ratio), and subjective visual vertical (SVV) deviation were collected and analyzed. Pearson or Spearman correlation analysis was used to examine the relationship between mean cervical JPS error and visual-vestibular function metrics. Results: Compared with the healthy control group, the CV group showed significantly greater cervical JPS error, as well as significantly abnormal vestibular ratio, sensory integration ratio in CDP-SOT, and SVV deviation (all P<0.001). Within the CV group, the mean cervical JPS error was significantly negatively correlated with the vestibular ratio (r=-0.658) and sensory integration ratio (r=-0.624), and positively correlated with the SVV deviation angle (r=0.573, all P<0.001). Multiple linear regression indicated that cervical JPS error was an independent factor predicting dizziness handicap inventory (DHI) scores (β=0.338, P=0.008). Conclusion: Patients with cervicogenic dizziness exhibit distinct abnormalities in cervical proprioceptive input, which are significantly correlated with impaired visual-vestibular central integration and spatial perception. This provides objective quantitative support for the sensory integration dysfunction mechanism in CV and suggests that clinical assessment and rehabilitation should focus on the restoration of sensorimotor integration function.
Copyright (c) 2025 Ye Gao, Xiangyang Wang https://creativecommons.org/licenses/by-nd/4.0
Research Progress on the Mechanism of Sanren Decoction in Treating Slow-Transit Constipation
Slow transit constipation (STC) is a prevalent functional gastrointestinal disorder characterized by impaired intestinal motility, prolonged fecal retention, and difficult defecation. Its pathological mechanisms may involve multiple factors, including enteric nervous system dysfunction, interstitial cell of Cajal impairment, gut microbiota dysbiosis, and neuroimmune dysregulation. Accumulating evidence-based medical research indicates that Sanren Decoction demonstrates significant therapeutic efficacy in treating slow transit constipation with spleen-stomach damp-heat syndrome, accompanied by a low recurrence rate. This article systematically reviews recent advances in mechanistic studies on Sanren Decoction for managing STC with damp-heat syndrome: analyzing its multi-target, multi-component, and multi-pathway regulatory mechanisms through the “regulating Sanjiao” theory, elucidating the pathogenesis of STC, and providing evidence-based foundations for clinical treatment and novel drug development.
Copyright (c) 2025 Beilei Duan, Hua Jiang, Yan Ma https://creativecommons.org/licenses/by-nd/4.0
Research Progress of Postoperative Recurrence of Chronic Subdural Hematoma in Chinese and Western Medicine
This review summarizes the risk factors associated with recurrent CSDH, including patient-specific factors, imaging factors, surgical factors, and pharmacological factors, while exploring the mechanisms underlying CSDH recurrence from the perspective of Traditional Chinese Medicine (TCM) theory. Aging is inextricably linked to CSDH, and the integration of TCM and Western medicine, along with anti-aging strategies, represents an effective approach to preventing CSDH recurrence.
Copyright (c) 2025 Xue Liu, Xiaoxuan Fan https://creativecommons.org/licenses/by-nd/4.0
Discussion on the Clinical Combined Acupuncture Therapy for Hirayama’s Disease
Hirayama disease (HD) is a self-limiting, benign motor neuron disorder that typically manifests during adolescence, clinically characterized by muscular weakness and atrophy affecting either a single limb or the asymmetric distal segments of the upper extremities. Currently, the etiology of HD is recognized as multifactorial and remains incompletely elucidated. Owing to its low clinical prevalence and heterogeneous manifestations, this condition is frequently susceptible to misdiagnosis and underdiagnosis in clinical settings. In Western medical practice, the diagnosis of HD is established through a comprehensive evaluation integrating clinical features, imaging findings, and neuroelectrophysiological studies, with conventional treatment primarily involving cervical collar immobilization or surgical intervention. From the perspective of traditional Chinese medicine (TCM), HD is categorized as “wei syndrome” [1]. The core therapeutic principles emphasize warming yang and unblocking meridians, activating local qi in the affected channels, regulating qi and blood circulation, and restoring the dynamic balance between yin and yang. This therapeutic strategy is designed to nourish the local meridians and musculature, thereby alleviating the associated clinical symptoms.
Copyright (c) 2025 Yujie Li, Weigang Wang https://creativecommons.org/licenses/by-nd/4.0
The Influence of Serum Lactate Dehydrogenase and Lactic Acid Levels on the Occurrence and Progression of Osteoporosis
Objective: By collecting and analyzing serum lactate dehydrogenase (LDH) and lactic acid levels in patients with osteoporosis, and comparing them with other common biochemical indicators used in osteoporosis diagnosis, this study aims to explore the impact of serum LDH and lactic acid levels on the occurrence and progression of osteoporosis, further clarify their relationship with osteoporosis, and provide new clinical evidence for the scientific prevention and treatment of osteoporosis. Methods: A retrospective analysis was conducted on 150 patients who underwent bone mineral density (BMD) measurement at the Bone Density Room of Tianjin Hospital from June 2024 to December 2024. Based on BMD T-scores, the patients were divided into three groups: normal bone mass, osteopenia, and osteoporosis, with 50 cases in each group. General data of the three groups, including name, gender, age, weight, height, BMI, serum LDH, lactic acid, and other related clinical biochemical indicators [alkaline phosphatase (ALP), serum calcium, serum phosphorus, uric acid, urine creatinine, cystatin C, P1NP, β-CTx were collected from the Clinical Laboratory of Tianjin Hospital. The correlation and degree of correlation between serum LDH, lactic acid and BMD T-scores were analyzed and compared with other clinical biochemical indicators. Differences within and between groups were also compared to comprehensively evaluate the impact of serum LDH, lactic acid levels, and other biochemical indicators on the occurrence and progression of osteoporosis. All clinical data collected in this study were approved by the Ethics Review Committee of Tianjin Hospital, complying with ethical requirements. Results: Comparative analysis showed that there was a significant negative correlation between serum LDH and BMD T-scores in 150 patients (correlation coefficient: -0.669), indicating that higher serum LDH levels were associated with lower BMD T-scores and more severe osteoporosis. In contrast, lactic acid levels showed a significant positive correlation with BMD T-scores (correlation coefficient: 0.732), meaning higher lactic acid levels were associated with higher BMD T-scores and milder osteoporosis. Comprehensive comparison of the correlation between other biochemical indicators and BMD T-scores revealed that serum calcium, serum phosphorus, and urine creatinine had a certain positive correlation with BMD T-scores, i.e., higher levels of these indicators were associated with higher BMD T-scores and milder osteoporosis. Conclusion: Serum LDH and lactic acid, as clinical biochemical markers, are significantly correlated with BMD T-scores. LDH is negatively correlated with BMD T-scores, while lactic acid is positively correlated with BMD T-scores. These two indicators have a significant impact on the occurrence and progression of osteoporosis. The conclusions of this study are expected to better guide the diagnosis and treatment of osteoporosis and provide more scientific basis for clinical decision-making.
Copyright (c) 2025 Lei Bai, Jingkun Jia, Zukang Miao, Zhiwei Pei, Hongjie Zhang, Hongwei Yang, Jianxiong Ma, Xinlong Ma https://creativecommons.org/licenses/by-nd/4.0
Advances in Prenatal Diagnosis and Genetic Research of Ciliopathies
Primary cilium is a kind of organelle that widely exists on the surface of various cells. It is small but complex in structure and has powerful effects. Cilia defects often lead to a series of disorders that are collectively termed “ciliopathies,” involving multiple systems. In recent years, it has been found that defects in ciliary morphology and function can lead to genetic diseases in newborns. Since cilia play a rather important role in regulating the balance of development and internal environment in vertebrates, the loss of genes related to cilia is associated with a range of diseases. Prenatal detection of renal abnormalities associated with skeletal or cerebral abnormalities should raise suspicion of multisystem ciliopathy, which is often associated with a variety of syndromes, including Meckel-Gruber syndrome, Joubert syndrome, Nephronophthisis, and Bardet-Biedl syndrome. Combined with recent studies, this article mainly summarizes four categories of cilia-related diseases in order to provide references for clinical diagnosis.
Copyright (c) 2025 Xingye Wei, Tao Wang, Pingping Zhang, Yanmei Sun https://creativecommons.org/licenses/by-nd/4.0
To Explore the Mechanism of Action of Face Needles
With the increasing demand for beauty in society, Western medicine beauty technology is gradually limited due to potential adverse reactions, and acupuncture beauty has attracted much attention because of its safety. Based on a two-year clinical follow-up practice, combined with Professor Hui Jianrong’s acupuncture theory, this study systematically explores the mechanism of action of facial acupuncture. This paper analyzes from the perspectives of traditional Chinese medicine and Western medicine: at the theoretical level of traditional Chinese medicine, based on the theory of yin and yang, qi and blood and Tibetan elephant theory, it is explained that the face needle realizes overall intervention by regulating the balance of qi and blood yin and yang and the function of the organs and meridians; At the level of Western medicine mechanism, from the perspectives of promoting minimally invasive tissue repair, regulating estrogen secretion, and optimizing local tissue metabolism, the biological basis of facial acupuncture to improve the skin microenvironment and delay aging is revealed. This study aims to provide a theoretical basis for the scientific connotation and clinical application of facial acupuncture therapy, and promote its standardized development in the field of aesthetic medicine.
Copyright (c) 2025 Tianen Chen, Jianrong Hui https://creativecommons.org/licenses/by-nd/4.0
Clinical Effect of Oral Motor Training Combined with Pediatric Tui-na on Feeding Intolerance in Preterm Infants
Objective: To investigate the intervention effect of oral motor training combined with pediatric tui-na on feeding intolerance in preterm infants to provide new treatment options and improve the quality of care. Methods: By using a non-simultaneous controlled clinical trial method, 75 eligible preterm infants from the neonatal unit of a tertiary care hospital in Jinan were selected as the experimental group to implement oral training combined with pediatric massage therapy. Another 60 preterm infants admitted in 2020 were selected as the control group, who had already received oral motor training but had not received pediatric massage. The experimental group was treated for 7 d and the efficacy of the two groups was compared. Comparisons between the two groups included signs of feeding intolerance such as vomiting, gastric remnants and other outcome indicators such as first oral feeding time, gastric tube retention time, increased milk volume at day 3 and increased milk volume at day 7, feeding initiation time, increased weight at day 3 and increased weight at day 7, recovery time of birth weight, and days of hospitalization in both groups. Results: The differences in gender, age, birth weight, and Apgar score between the two groups before treatment were not statistically significant (P>0.05) indicating comparability. After treatment, preterm infants in the experimental group showed significant improvement in feeding performance, first oral feeding time, gastric tube retention time, increased milk volume at day 3 and increased milk volume at day 7, increased weight at day 3 and increased weight at day 7, hospitalization days and other observed indexes compared with the control group, and the differences were statistically significant (P<0.05). There was no significant difference in the feeding initiation time and recovery time of birth weight between the two groups (P>0.05). Conclusion: The combined application of oral motor training and pediatric tui-na is significantly more effective than single oral motor training in the short-term treatment of feeding intolerance in preterm infants. This combination therapy helps preterm infants to increase milk intake and accelerate weight gain, helps the children to recover intestinal function, establishes early nutritional support, promotes growth and development, and reduces the risk of long-term complications. This treatment is simple safe and efficient, and has the value of popularization.
Copyright (c) 2025 Wei Li, Yudan Ling, Rongqiu Li, Xiaomei Lu, Huaxiang Lu, Fengdan Liang https://creativecommons.org/licenses/by-nd/4.0
Application of Spectral CT Hemobase Imaging in Renal Perfusion Assessment Before and After Partial Nephrectomy for Renal Carcinoma
Objective: To investigate the significant clinical value of spectral CT hemobase imaging in evaluating renal perfusion function before and after partial nephrectomy for renal cell carcinoma. As described in “Research on Renal CT Perfusion Imaging and Its Clinical Application Value”, this technique provides quantitative analysis of renal perfusion values, aiding in prognosis assessment and surgical strategy selection for renal cancer patients. Methods: A total of 70 patients undergoing partial nephrectomy for renal cell carcinoma from June 2024 to June 2025 were randomly divided into a study group (35 cases) and a control group (35 cases). The study group received spectral CT hemobase imaging to improve early diagnostic accuracy, while the control group underwent conventional contrast-enhanced CT. Preoperative and postoperative 7-day changes in iodine-based substance concentration (IC), spectral curve slope (λHU), effective atomic number (Zeff), renal blood flow (RBF), renal blood volume (RBV), and mean transit time (MTT) were compared. Results: The study group showed significantly higher postoperative IC, λHU, Zeff, RBF, and RBV compared to the control group, with significantly lower MTT (P<0.05). Conclusion: Spectral CT hemobase imaging accurately reflects changes in renal parenchymal microcirculation perfusion during partial nephrectomy for renal cell carcinoma. Compared to conventional contrast-enhanced CT, it demonstrates higher sensitivity and quantitative analysis value, which holds important clinical significance for evaluating postoperative renal function and prognosis.
Copyright (c) 2025 Jian Yan, Liansheng Zheng, Mengwei Shi, Bo Duan, Jing He https://creativecommons.org/licenses/by-nd/4.0
Public Awareness of Cancer Risk Factors and Symptoms: A Population-Based Assessment
Background: The most prevalent malignancy is breast cancer (BC). BC was the cause of 10.6% of deaths in India and 13.5% of all cancer diagnoses, according to Globocan 2020. In this study, female patients in an urban private clinic in Central India were asked to rate their awareness and knowledge of breast cancer risk factors, symptoms, and screening procedures. Materials & Methods: A cross - sectional survey was conducted from July to December 2022 on a sample of 75 participants at an Urban private clinic in Central India. Results: Out of 75 participants in the study, 50 (66.6%) were unaware of any risk factors for breast cancer, which is the majority. Only 6 (8%), 4 (5.2%), and 3 (4%) recognised that having a first child after the age of 30 was a risk factor for breast cancer, as well as the family history of the disease. Three (4%) also knew that having a late menopause was a risk factor. The majority of subjects, 64 in total (85.3%), were unaware of any breast cancer symptoms. Three respondents (40%) knew all the symptoms of breast cancer, four subjects (40%) knew about painless lumps in the breast or armpit as a symptom, and two individuals (2.6%) knew about changes in the size, shape, or colour of the breast as a symptom. Similar to this, 6 (8%) of the individuals knew about mammography, while 60 (80%) of the subjects had no knowledge of any procedure. While only 2 (2.6%) of the individuals were aware of self - breast examination, 5 (6.6%) of the subjects were aware of all screening and detection strategies for breast cancer. Conclusion: Participants in the current study had extremely limited understanding of risk factors, symptoms, and screening and preventative techniques. Programmes to increase public awareness are desperately needed.
Copyright (c) 2025 Asawari Deshmukh, Sanika Deshmukh https://creativecommons.org/licenses/by-nd/4.0
Comparative Effectiveness of Motor Relearning vs. Proprioceptive Neuromuscular Facilitation on Functional Mobility in Chronic Stroke Patients: A Randomized Controlled Trial
Aim of the study: The study is aimed to investigate the effectiveness of motor relearning along with proprioceptive neuromuscular facilitation on improving functional mobility in subjects with chronic stroke. Objective of the study: The objective of the study is to enlighten the effectiveness motor relearning along with proprioceptive neuromuscular facilitation in improving functional mobility in subjects with Chronic stroke. Methodology: Study design: Experimental study design. Sample size: 28 subjects with chronic stroke with functional mobility impairment were selected. Procedure: Twenty eight subjects aged 45 to 55 years with stroke under Brunnstrom recovery stage IV and V were selected and assigned into two groups control group and experimental group with 14 subjects each, control group received PNF and the experimental group received PNF along with motor relearning program for a period of 4 weeks. Outcome measures: Extended timed up and go test (ETUG) was used to evaluate the functional mobility before and after the treatment. Results & Conclusion: The paired t test was used for within group analysis. The t values of control group for ETUG components sit to stand, walk 1, turn, walk 2, turn sit, walk speed ware21.469, 9.234, 35.133, 11.259, 14.587, 29.077 and p value were 0.00 through SPSS. 17 version. The paired t test was used for within group analysis. The t values of experimental group for ETUG components sit to stand, walk 1, turn, walk 2, turn sit, walk speed were 19.795, 21.500, 15.985, 14.343, 18.189, 26.858 and p value were 0.00through SPSS. 17 version. The result showed significant improvement in within group analysis. The unpaired t test was used to analysis between groups. The F value of ETUG components walk 2 and turn sit ware 4.731, 8.217 and p value of the same were 0.038, 0.008 respectively. The result showed that there were significant difference between control and experimental group in walk2 and turn to sit components Hence it can be concluded that PNF along with motor relearning show improvement in functional mobility that subjects treated with PNF alone.
Copyright (c) 2025 Karwal Agusum https://creativecommons.org/licenses/by-nd/4.0
Mitochondrial Dysfunction and Hypochondriasis
Cyberchondria is the overuse of the internet to diagnose one's own health issues, which causes worry to rise. People who are prone to health anxiety are kept in the cycle of anxiety by researching symptoms online. One such negative effect is cyberchondria, which is the increase in anxiety associated by frequent Internet searches for medical information. A person must resist the impulse to go online and control their media use if they want to reduce cyberchondria and other health anxiety - related habits.
Copyright (c) 2025 Agarwal Sureatil https://creativecommons.org/licenses/by-nd/4.0
This article provides a comprehensive overview of Polycystic Ovary Syndrome PCOS, a common endocrine disorder in women. It explores the causes, symptoms, diagnosis, and management strategies for PCOS, with a focus on lifestyle modifications and medical treatments. The article also discusses the potential complications and risks associated with the condition.
Copyright (c) 2025 Nikoloudakis Nikthew https://creativecommons.org/licenses/by-nd/4.0
Neuroplasticity and Functional Recovery Following Brain Injury
“Traumatic Brain Injury (TBI)” is stimulating for both diagnosis and treatment. It consists of physiological or structural injuries in brain function along with external forces. These injuries may cause formation of gliotic scar, cellular death, and damage from inflammation and reactive oxygen. A lot of research attention has been given to external influencers to promote neuroplasticity with significant effects on neurologic injury treatment. A lot of these methods and existing studies are reviewed in this study. With advancements in neuroscience, an in - depth knowledge of the intricacy of interconnection in the brain and its capability to adapt to the environment is “promoting neurorehabilitation which augments the capacity of brain to adapt with neuroplastic change”. This systematic review has been conducted to explore the benefits of innovative technologies used for neurorehabilitation of patients suffering from brain injury. There has been a rise in recognition and appreciation of neuroplasticity which has brought modern approaches to encourage neuro - recovery, which boosts stimulation and secretion of neutrophic factors. Some of the modern approaches are non - invasive stimulation, pharmacologic agents, task - based and aerobic exercise, mirror therapy, and improvement of sleep. Future studies are needed to build the foundation of therapeutic techniques and rehabilitation to promote natural healing of brain and functional results.
Copyright (c) 2025 Mathew Stevupta https://creativecommons.org/licenses/by-nd/4.0
Prevalence of Digital Eye Strain Among College Students in the Post‑COVID‑19 Era: A Cross‑Sectional Survey Study
Purpose of this study: The main aim of this study is to assess the relationship between digital eye strain and exposure to digital devices among college students post covid outbreak in the year 2021. Methodology: For the above study, sixty three students are selected purposively and surveyed using a pre designed self - administered questionnaire on digital eye strain. Results: Sixty three students are studied and tables and charts are made accordingly. From the table we can see that, digital eye strain is associated with number of hours exposed to the screen and number of days of device used. Conclusion: Digital eye strain (DES), also known as computer vision syndrome, encompasses a range of ocular and visual symptoms, and estimates suggest its prevalence may be 50% or more among computer users. Symptoms fall into two main categories: those linked to accommodative or binocular vision stress and external symptoms linked to dry eye. At greatest risk for developing DES are those persons who spend two or more continuous hours at a computer or using a digital screen device every day. Solutions to digital screen - related vision problems are varied. However, they can usually be alleviated by obtaining regular eye care and making changes in how the screen is viewed. In some cases, individuals who do not require the use of eyeglasses for other daily activities may benefit from glasses prescribed specifically for computer use. In addition, persons already wearing glasses may find their current prescription does not provide optimal vision for viewing a computer.
Copyright (c) 2025 Touvykine Deboumar https://creativecommons.org/licenses/by-nd/4.0
A Randomized Controlled Trial of Meridian-Guided Fire Dragon Cupping and Moxibustion for Improving Limb Pain and Numbness in Diabetic Peripheral Neuropathy
Objective: To evaluate the clinical efficacy and safety of Meridian-Guided Fire Dragon Cupping and Moxibustion (MGFDCM) in improving limb pain, numbness, and nerve function in patients with diabetic peripheral neuropathy (DPN) presenting with the pattern of Qi deficiency and blood stasis. Methods: A randomized, single-blind, parallel-controlled trial was conducted. Seventy-two eligible patients were randomly assigned in a 1:1 ratio to either a treatment group or a control group n=36. Both groups maintained basic glucose-lowering and neurotrophic therapy. The treatment group received MGFDCM, while the control group received simulated cupping treatment, three times per week for 4 weeks. The primary outcome measures were pain and numbness symptom scores assessed using a Visual Analogue Scale (VAS). Secondary outcomes included the Toronto Clinical Neuropathy Score (TCSS), a Traditional Chinese Medicine (TCM) syndrome score, and nerve conduction velocity (NCV). Results: After treatment, improvement in the primary outcomes was significantly greater in the treatment group than in the control group: the mean reduction in VAS pain score was (4.2 ± 1.1) points versus (1.8 ± 0.9) points, and the mean reduction in numbness score was (3.5 ± 0.8) points versus (1.6 ± 0.7) points (all P < 0.01). For secondary outcomes, the treatment group also showed superior results: a lower post-treatment TCSS total score [(5.2 ± 2.1) vs. (8.9 ± 2.4), P < 0.01], a greater reduction in the TCM syndrome score [(12.5 ± 3.2) points vs. (5.8 ± 2.7) points, P < 0.01], and more pronounced improvements in the motor and sensory NCV of both the median and common peroneal nerves (all P < 0.05). During treatment, only two cases in the treatment group experienced transient local skin redness, and no serious adverse events were reported. Conclusion: Meridian-Guided Fire Dragon Cupping and Moxibustion is a safe and effective intervention for alleviating limb pain and numbness and for promoting nerve function recovery in DPN patients with the pattern of Qi deficiency and blood stasis. Its therapeutic effect is significantly superior to simulated treatment, warranting clinical application and promotion.
Copyright (c) 2025 Liu Na https://creativecommons.org/licenses/by-nd/4.0
Research Advances in Traditional Chinese Medicine for the Treatment of Alzheimer’s Disease
Alzheimer’s disease (AD) is a major neurodegenerative disease that plagues the elderly population, clinically characterized by progressive cognitive decline, neuropsychiatric symptoms, and loss of social function. Epidemiological data from 2020 shows that the number of AD patients aged 60 and above in China has reached approximately 9.83 million. The accelerating trend of population aging has made the disease burden of AD increasingly heavy, posing a public health challenge that cannot be ignored. The etiology of AD remains unclear, and its pathological mechanisms are complex. Characteristic changes include senile plaques formed by extracellular amyloid-β (Aβ) deposition, neurofibrillary tangles mediated by hyperphosphorylated Tau protein, and subsequent synaptic damage and neuronal loss. Current mainstream treatment regimens primarily consist of acetylcholinesterase inhibitors and NMDA receptor antagonists. While these can temporarily alleviate some symptoms, they are unable to halt or reverse the disease process, and are limited by their single-target mechanism of action and the relatively high incidence of adverse effects associated with long-term use. Within the theoretical system of Traditional Chinese Medicine (TCM), AD is classified under categories such as “dementia”, “stupidity”, and “forgetfulness”. Based on the traditional understanding that “the kidney stores essence, produces marrow, and fills the brain,” TCM has accumulated rich experience through long-term clinical practice, gradually forming treatment strategies characterized by a holistic view and syndrome differentiation, involving multi-pathway interventions. A substantial body of research demonstrates that Chinese herbal medicines and their active components exhibit unique advantages of multi-target, systemic regulation in improving cognitive function and delaying disease progression in AD patients, with a good safety profile. This article focuses on three levels—TCM compound formulas, single Chinese herbs, and active components—to systematically review recent relevant experimental research, deeply explore their potential mechanisms of action, and provide valuable ideas and references for the TCM-based prevention and treatment of AD and the development of new drugs.
Copyright (c) 2025 Honghong Cui, Zhenliang Hui, Rongrong Cao, Xiaole Zhang https://creativecommons.org/licenses/by-nd/4.0
Analysis of Jia ChengWen’s Experience in Treating Old Facial Paralysis with Superficial Needling of Double Needles Based on the Theory of “Strengthening Vital Qi and Eliminating Pathogenic Factors
This article summarizes the experience of Jia Chengwen, a famous traditional Chinese medicine doctor in Shaanxi Province, in treating facial paralysis with the combination of the theory of “strengthening vital qi and eliminating pathogenic factors” and the technique of superficial needling of double needles. Professor Jia Chengwen follows the idea of “When the healthy qi exists within the body, pathogenic factors cannot invade” from the Inner Canon of Huangdi. He emphasizes “gentleness and superficiality” in his needling technique and selects acupoints “few but essential”. He believes that “deficiency of healthy qi and long-term retention of pathogenic factors” is the key to the pathogenesis of this disease, and pays attention to “strengthening vital qi and eliminating pathogenic factors” during treatment. The technique of inserting two needles at one acupoint, combined with the principle of “the meridians pass through, and the acupoints can treat the related areas”, uses gentle and superficial needling to strengthen vital qi and eliminate pathogenic factors, stimulate the meridian qi, and take “unblocking” as the application, so as to achieve quick effects when qi arrives. It has achieved remarkable effects in clinical treatment, hoping to provide reference and inspiration.
Copyright (c) 2025 Zhi Liang, Jie Zheng, Chengwen Jia https://creativecommons.org/licenses/by-nd/4.0
Exploring the Balance of Traditional Chinese Medicine (TCM) Wellness through the “Health Preservation Chapter” of Huangdi Neijing
With societal progress and era development, people increasingly value wellness, recognizing its importance. The wellness philosophy of TCM primarily emphasizes disease prevention, health maintenance, and longevity. Huangdi Neijing, the theoretical foundation of TCM, profoundly reflects ancient understandings of natural laws, human physiology, and societal development, encapsulating unique insights into life phenomena, essence, and rhythms. By investigating its wellness content, we gain novel perspectives for modern life and medical advancement, offering valuable references for contemporary wellness practices.
Copyright (c) 2025 Rongrong Cao, Zhenliang Hui, Honghong Cui, Xiaole Zhang https://creativecommons.org/licenses/by-nd/4.0