Research Progress of Chinese Medicine in Regulating Relevant Signalling Pathways for the Treatment of Ulcerative Colitis
DOI:
https://doi.org/10.53469/jcmp.2024.06(08).20Keywords:
Traditional Chinese medicine, Signalling pathways, Ulcerative colitis, Research progressAbstract
Ulcerative colitis (UC) is a recurrent, chronic inflammatory bowel disease with varying severity and prolonged healing, and Western medicine drug treatment has certain side effects. In recent years, a large number of animal experimental studies have demonstrated that traditional Chinese medicine (TCM) can reduce the inflammatory response and improve intestinal inflammation by interfering with the relevant signalling pathways, effectively improving the symptoms of patients with ulcerative colitis. The purpose of this article is to summarise the relevant articles on the modulation of relevant signalling pathways by TCM for the treatment of ulcerative colitis in recent years, and to provide new ideas for the active exploration of UC drug therapy.
References
Chen, Wang Jianan. Internal medicine[M]. Beijing: People's Health Press, 2015:487- 493.
Shen Hong, Zhu Lei, Zou Jiandong. Review and analysis of clinical characteristics of 500 inpatients with ulcerative colitis [J]. Beijing Traditional Chinese Medicine, 2018,37(07):598-601.
Xiang Yanru. Exploring the mechanism of curcumin in the treatment of ulcerative colitis based on the iron death-related signalling pathway[D]. Nanchang University, 2023.
Du L, Ha C. Epidemiology and Pathogenesis of Ulcerative Colitis. Gastroenterol Clin North Am. 2020 Dec;49(4):643-654.
PENG Ming-Xing, XIE Hui-Chen. Research progress of Chinese traditional medicine and its active ingredients in the treatment of ulcerative colitis regulating cytokines[J]. Journal of Hubei College of Nationalities (Medical Edition), 2019, 36 (04): 50-53.
Gao Feiyun, Liu Ting, Zhang Huahong, et al. Progress of research on the pathogenesis of ulcerative colitis based on NF-κB pathway and the intervention effect of traditional Chinese medicine[J]. Chinese Journal of Traditional Chinese Medicine, 2023, 41 (06): 123-127.
LU Xiaolong, YU Yongduo, LIU Yuedong, et al. "An analysis of ulcerative colitis treated with carbuncle[J]. Chinese Journal of Traditional Chinese Medicine: 1-11[2024-05-01].
YANG Wendi, LI Wei, XU Boyang, et al. Discussion on the etiology and pathogenesis of ulcerative colitis and the advantages of traditional Chinese medicine treatment[J]. Journal of Shanxi Datong University (Natural Science Edition), 2023,39(06):92-95.
Ungaro R, Mehandru S, Allen P B, et al. Ulcerative colitis[J]. Lancet,2017,389 (10080):1756-70.
Bressler B,Marshall J K,Bernstein C N, et al. Clinical practice guidelines for the medical management of nonhospitalized ulcerative colitis: the Toronto consensus[J]. Gastroenterology, 2015, 148 (5): 1035-1058 e3.
SONG Yan, HE Yongheng, YANG Fang, et al. Therapeutic effects of astragalus polysaccharide modulating the lipocalin/TLR/NF-κB signalling pathway in mice with ulcerative colitis[J]. Chinese Journal of Immunology, 2021,37(11):1319-1324.
YANG Lingxia, WANG Wei, LIU Ping, et al. Effects of wuzhuine on HMGB1/TLR-4/NF-κB signalling pathway in rats with ulcerative colitis[J]. Chinese Journal of Gerontology, 2024, 44 (01): 237-241.
LIU Jinghong, WAN Yun, LIU Xiaolong, et al. Effect of resveratrol modulation of TLR4/NF-κB signalling pathway on inflammatory response in rats with ulcerative colitis[J]. Chinese Journal of Gerontology, 2023, 43 (24): 6078-6082.
SoendergaardC, BergenheimFH, BjerrumJT, etal. Tar-geting JAK-STAT signal transduction in IBD[J]. Phar-macol Ther, 2018,192:100-111.
GUO De-Wei, WEI Rong-Huang, CHEN Quan-Heng, et al. Exploring the application of traditional Chinese medicine in ulcerative colitis based on JAK/STAT signalling pathway[J]. Popular Science and Technology, 2023,25(10):81-85+97.
Lu Huidong, Li Yanmei. Atractylenolide III attenuates intestinal injury in ulcerative colitis model mice by regulating JAK2/STAT3 signalling pathway[J]. Chinese Journal of Pathophysiology,2023,39(01):142-149.
LI Chunlin, LI Shichao, JIA Yingtian, et al. Investigation of the effect of flavopiridol on apoptosis of colonic dermal cells in mice with ulcerative colitis based on JAK/STAT signalling pathway[J]. Chinese Journal of Pharmacology,2023,39(05):938-945.
XU Tang, YAN Hongmei, CHEN Glimmer. Effects of Xianmaooside on JAK/STAT/NF-κB signalling pathway in rats with ulcerative colitis[J]. Chinese Pharmacist, 2022,25(03):406-413.
Xu Ran, Zhang Maomao, Yang Ruotong, et al. Research progress on the intervention of traditional Chinese medicine on cell signalling pathway related to ulcerative colitis[J/OL]. Journal of Anhui University of Traditional Chinese Medicine:1-9[2024-07-05].
LIU Yu, GUO Yuhui, LI Yanli, et al. Study on the mechanism of action of Epimedium total flavonoids in the treatment of ulcerative colitis based on network pharmacology[J]. Journal of Shenyang Pharmaceutical University,2022,39(04):454-463.
ZHOU Xiaonan, HAN Chao, SONG Pengyan, et al. Study on the in vitro anti-inflammatory effects of lignans and quercetin[J]. Advances in Animal Medicine, 2017,38(10):56-61.
Lin Xiong. Pharmacological efficacy and mechanism of Cangzhu on ulcerative colitis in mice based on MAPK/NF-κB signalling pathway[D]. Hubei University of Traditional Chinese Medicine,2023.
Chen G, Gu W, Wu Y, et al. Study on the treatment of ulcerative colitis in mice with spleen-healing pills based on the regulation of inflammatory factors and up-regulation of intestinal tight junction proteins[J]. Pharmacology and Clinics of Traditional Chinese Medicine:1-19[2024-07-05].
Luo Yaqin, Huang Wei. Progress on the mechanism of Scutellaria baicalensis and its active ingredients in the treatment of ulcerative colitis[J]. Shandong Science, 2024,37(02):20-28.
Wang G, Huang WL. Research progress of immunoregulatory mechanism of ulcerative colitis[J]. Journal of Jilin Medical College,2023,44(05):363-366.
SONG Zizhuan, LIU Fulin, XIA Xuting, et al. Progress on the mechanism of action of ginseng and its active ingredients in the treatment of ulcerative colitis[J]. Global Chinese Medicine,2023,16(03):577-582.
Liang Lei, Peng Xin, Xin Liqiong, et al. Progress of research on the mechanism of action of hemixia diarrhoea heart soup in the treatment of ulcerative colitis[J/OL]. Global Chinese medicine: 1-8[2024-07-05].
NG Xiaohan, LIU Zhanju. Recent understanding of the pathogenesis of ulcerative colitis[J]. Chinese Journal of Integrative Medicine and Digestion, 2023,31(04):237-242.
WANG Bo, CHEN Yanping, ZHANG Lide, et al. Experimental study on the permeability of intestinal mucosa of mice with ulcerative colitis by Chinese medicine Sophora japonica[J/OL]. Chinese Journal of Traditional Chinese Medicine:1-13[2024-07-05].
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