Research Progress on the Treatment of Ulcerative Colitis with Shenling Baizhu Powder

Abstract

Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized by recurrence, difficulty in curing, and the risk of accelerated colon cancer. Shenling Baizhu Powder, from “Prescriptions People’s Welfare Pharmacy”, is a classic prescription for treating diarrhea of spleen deficiency and dampness accumulation type, with the core therapeutic principle of “tonifying qi and strengthening the spleen, removing dampness and stopping diarrhea”, and is a commonly used prescription for treating UC. Through a multi-dimensional review of the clinical research and mechanism of action of Shenling Baizhu Powder for the treatment of UC, it is concluded that Shenling Baizhu Powder can be applied through the original formula, combined with Western medicine, compound, etc. In regulating gut microbiota, promoting tight junctions between intestinal epithelium, promoting mucin secretion, regulating immune response, alleviating oxidative stress, regulating water metabolism, inhibiting Toll-like receptor-4 (TLR4)/pro-inflammatory transcription factor nuclear transcription factor-KB (NF-κB), TLR-5/myeloid differentiation factor (MyD88)/NF-KB, β2-epinephrine The receptor (β2AR)/arrestin2/NF-κB signaling pathways act, providing a theoretical basis for the clinical application of Shenling Baizhu Powder in the treatment of UC.