Research Progress of Chinese Medicine in Regulating Relevant Signalling Pathways for the Treatment of GU

Abstract

Gastric ulcer (GU) is a common digestive system disease in clinic. In recent years, the incidence of GU has increased year by year. Modern medical treatment mainly adopts symptomatic support therapies such as helicobacter pylori eradication therapy, acid suppression, and protection of gastrointestinal mucosa. However, these treatments have shortcomings such as high recurrence rate and many adverse reactions. Studies have shown that traditional Chinese medicine (TCM) plays an anti oxidative stress, anti-inflammatory and anti apoptotic role by regulating relevant signaling pathways through multiple pathways, multiple component and multiple targets, and promotes the repair of gastrointestinal mucosa, with PI3K/Akt, MAPK, NF-κβ and other signaling pathways as the core mechanism. This paper systematically expounds the research progress of TCM in the treatment of GU by regulating key signaling pathways, and summarizes the research progress of single TCM, TCM compound and Chinese patent medicine in the treatment of GU by regulating PI3K/Akt, MAPK and NF-κβ pathways through consulting the relevant literature.