Research Progress on the Antitumor Effects and Clinical Applications of Yangzheng Xiaoji Capsules

Abstract

Yangzheng Xiaoji Capsule is a modern compound preparation of traditional Chinese medicine (TCM) developed based on the TCM theories of “Fuzheng Quxie” (Strengthening the Body’s Resistance and Eliminating Pathogenic Factors) and “Jianpi Xiaoji” (Strengthening the Spleen and Resolving Masses). It is widely used in the adjuvant therapy of tumors. Substantial basic and clinical research confirms that it not only exerts “Quxie” (Pathogen-Eliminating) effects by directly inhibiting tumor cell proliferation, inducing apoptosis, and suppressing invasion and metastasis but also achieves “Fuzheng” (Body-Resistance-Strengthening) effects by regulating the body’s immune function, reducing the side effects of radiotherapy and chemotherapy, and improving cachexia. This article aims to systematically review the latest research progress regarding the antitumor mechanisms of Yangzheng Xiaoji Capsules (including inducing apoptosis and autophagy, inhibiting angiogenesis and metastasis, regulating the tumor microenvironment, immune regulation, chemosensitization, and toxicity reduction) and their clinical applications (its adjuvant therapeutic role in various solid tumors such as liver cancer, gastric cancer, lung cancer, colorectal cancer, and its impact on quality of life). It also provides an outlook on future research directions, hoping to offer a reference for in-depth study and rational clinical application of this drug.