Research Progress on the Impact of Traditional Chinese Medicine Treatment on Tumor Microenvironment
DOI:
https://doi.org/10.53469/jcmp.2024.06(11).32Keywords:
Traditional Chinese medicine, Tumor microenvironment, Research progressAbstract
Tumor microenvironment mainly includes non-tumor cells, cytokines, chemokines and extracellular matrix. It is an important part of anti-tumor immunity and plays a vital role in the formation and invasion of tumors. Anti-tumor treatment is in line with the concept of "Fuzheng anti-cancer" of traditional Chinese medicine, and the regulation of anti-tumor traditional Chinese medicine on the tumor microenvironment can be expounded based on the body's immunomodulation mechanism. It discusses strengthening the body's immune barrier, curbing tumor growth from the source, and reversing the microenvironment that is conducive to tumor survival; it can guide the normalization of tumor blood vessels to reduce the probability of tumor infiltration, metastasis and recurrence; and improve the quality of life of the host by reducing adverse reactions caused by therapeutic drugs.
References
GAO Ming, WANG Tong, YANG ChunYu, et al. Latest development of traditional Chinese medicine immunotherapy based on tumor microenvironment[J]. Chinese Journal of Immunology, 2021, 7(4): 506-510.
WU T, DAI Y. Tumor microenvironment and therapeutic response[J]. Cancer Lett, 2017, 387: 61-68.
IN M Z, JIN W L. The updated landscape of tumor microenvironment and drug repurposing[J]. Signal Transduct Target Ther, 2020, 5(1): 166.
KLEMM F, JOYCE J A. Microenvironmental regulation of therapeutic response in cancer[J]. Trends Cell Biol, 2015, 25(4):198-213.
ZHANG Y, HAN X, NIE G. Responsive and activable nanomedicines for remoedling the tumor microenvironment [J]. Nat Protoc, 2020.
LIN W F, LU J Y, CHENG B B, et al. Progress in research on the effects of traditional Chinese medicine on the tumor microenvironment[J]. J Integrat Med, 2017, 15(4): 282-287.
LIN Yi, TAO Li. Theoretical conception of traditional Chinese medicine for metastasis of colorectal cancer[J]. Shanghai Journal of Traditional Chinese Medicine, 2020, 54 (2): 6-9.
Huang Di Nei Jing · Su Wen · Ci Fa Lun [M]. 2nd edition. Kunming: Yunnan Education Publishing House, 2011: 255-263.
Huang Di Nei Jing · Su Wen ·Ping Re Bing Lun[M]. 2nd edition. Kunming: Yunnan Education Publishing House, 2011:106-108.
Li Zhongzi. Zong Yi Bi Du·Juji[M]. Tianjin: Tianjin Science and Technology Press, 2012: 206-207.
Liu Jiaxiang. Treating Cancer by Strengthening Vital Qi-A Inherited and Inovative Method with Integrating Chinese and Western Medicine[J]. Chinese Journal of Integrated Traditional and Western Medicine, 2019, 39(1):10-12.
Li Yuchuan, Liu Yujie, Zhang Yuanzhe, etc. Experimental study of Bazhen soup combined with chemotherapy drugs to treat S-180 sarcoma in mice[J]. Lishizhen Medicine and Materia Medica Research, 2016, 27(12): 2857-2849.
TSIOUMPEKOU, CUNHA SI, MA H, et al. Specific targering of PDGFRβin the stroma inhibits growth and angiogensis in tumors with high PDGF-BB expression [J]. THERANOSTICS, 2020, 10(3): 1122-1135.
WANG Y, JIANG H, LUO H, et al. An IL-4/21 linverted cytokine receptor improving CAR-T Cell potency in immuno suppressive solid tumor microeniranment [J], Frontiers in Immunology, 2019, 10:1691.
GRETEN F, GRIVENNIKOVS. Inflammation and cancer: triggers mechanisms, and consequences[J]. Immunity, 2019, 51(1): 27-41.
Cao Huiqiong, Cai Qinghong. The relationship between the expression of hypoxia-induced factor-1αand vascular endothelial growth factor and gastric cancer vascular production[J]. Jilin Medical Journal, 2020, 41(1): 184-185.
HAN L, YAOS CAOS, et al. Triterpenoid saponins from anemne fiaccida suppress tumor cell proilferation by regulating MAPK, PD1/PDL1, and STAT3 signaling pattways and altering cancer metbolis[J]. 2019, 12: 10917-10930.
LIANG Ying, CHENG Gang, HUANG Denggao. Preventive Mechanism of Yipi Huoxue Recipe on Postoperative Recurrence for Rats after Hepatectomy by Regulating B7-H1/PD-1Signal Pathway[J]. Journal of Sichuan of Traditional Chinese Medicine, 2019, 37(8): 24-27.
Zheng Jimei, Wu Feipeng, Song Sucai, et al. The Progress of Research on Anti-Tumor Chinese Medicine on Tumor Micro-Environment Immune Regulation[J]. 2020, 16(6): 185-189.
KIM MS, KIM H, AHNEK, et al. Novel functions for 2-phenylbenzimindazole-5-suphnicacid: Inhinbition of varian cancer cell resopnses and tumour angiogenesis[J]. JCell Mol Med, 2020, 24(4): 2688-2700.
Pan Huafeng, Zhao Ziming, Shi Yafei, etc. Effects of strengthening the spleen, removing blood stasis and detoxification on inflammatory factors, gastric secretion and motor function in rats with precancerous lesions [C]//Chinese Society of Integrated Traditional Chinese and Western Medicine. Materials of the 13th China Basic Theory Conference on Integrated Traditional Chinese and Western Medicine and the Training Course for Grassroots Doctors in Integrated Management of Traditional Chinese Medicine in County and Townships. Beijing: Chinese Society of Integrated Traditional Chinese and Western Medicine, 2017: 167-169.
Huang Sha, Yang Jianwei, Huang Junshan, et al. Clinical Observation on Xiaozhang Yiliu Fang Combined with Chemotherapy in Treating 35 Cases of Gastric Cancer-induced Malignant Ascites[J]. Journal of Traditional Chinese Medicine, 2017, 58(11): 936-940.
ERIC T U, PEI ZHI CHERYL CHIA, WANJUN CHEN. TGF-βin T cell biology and tumor immunity[J]. Angel or devi, 2014, 25(4): 423-435.
RAMANATHAN S, JAGANNATHAN N. Tumor associated macrophage: A review on the phenotypes, traits and functions[J]. Iran J Cancer Prev, 2014, 7(1): 1-8.
KESKIN S, KUTLUK A C, TAS F. Prognostic and predictive role of angiogenic markers in non-small cell lung cancer[J]. Asian Pac J Cancer Prev, 2019, 20(3): 733-736.
WANG W J, WU Y S, CHEN S, et al. Mushroom β-glucan mayimmunomodulate the tumor-associated macrophages in the lewis lung carcinoma[J]. Biomed Res Int, 2015, 2015: 604385.
PANG L N, HAN S Y, JIAO Y N, et al. Bu Fei Decoction attenuates the tumor associated macrophage stimulated proliferation, migration, invasion and immunosuppression of non-small cell lung cancer, partially via IL-10 and PD-1 regulation[J]. Oncology, 2017, 51(1): 25-38.
KONG F, LI FE, HE Z, et al. Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from Pleurotus ostreatus[J]. Inter J Biol Macromol, 2014, 69(8): 561-566.
GUO T, YANG Y, GAO M, et al. Lepidium meyenii Walpers polysaccharide and its cationic derivative re-educate tumor-associated macrophages for synergistic tumor immunotherapy[J]. Carbohydr Polym, 2020, 15(250):116904.
SHIGA K, HARA M, NAGASAKI T, et al. Cancer-associated fibroblasts: Their characteristics and their roles in tumor growth[J]. Cancers (Basel), 2015, 7(4): 2443-2458.
KOBAYASHI H, ENOMOTO A, WOODS S L, et al. Cancer associated fibroblasts in gastrointestinal cancer[J]. Nat Rev Gastroenterol Hepatol, 2019, 16(5): 282-295.
WANG Q, QU C, XIE F, et al. Curcumin suppresses epithelialto mesenchymal transition and metastasis of pancreatic cancer cells by inhibiting cancer-associated fibroblasts[J]. Cancer Res, 2017, 7(1): 125-133.
HAN S Y, HU MH, QI G Y, et al. Polysaccharides from polygonatum inhibit the proliferation of prostate cancer-associated fibrolasts cells[J]. Cancer Prev, 2016, 17(8): 3839-3833.
ZHOU B, YU Y, YU L, et al. Sipi soup inhibits cancerassociated fibroblast activation and the inflammatory process by downregulating long noncoding RNA HIPK1AS[J]. Mol Med Rep, 2018, 18(2): 1361-1368.
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Copyright (c) 2024 Bin Jiang, Zhen Wang, Jia Yuan, Jianfeng Quan
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