Research Progress of the Medicine-food Herbs Against Alcoholic Liver Disease

Authors

  • Xinyi Wang Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Bao Xin Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China

DOI:

https://doi.org/10.53469/jcmp.2024.06(10).17

Keywords:

The medicine-food herbs, Alcoholic liver disease, Mechanism, Active ingredient, Research progress

Abstract

This article analyzes the data from the Special Food Information Query Platform of the Special Food Safety Supervision and Administration Department of the State Administration for Market Regulation, and finds that among the approved health foods in China that have auxiliary protective functions against chemical liver injury, there are 43 medicinal and the medicine-food herbs as raw materials. These traditional Chinese medicines mainly exert protective effects against alcoholic liver injury through mechanisms such as inhibiting free radical release, anti lipid peroxidation, antioxidant stress response, and anti-inflammatory response. Among them, the medicine-food herbs such as kudzu root, lingzhi, goji berry, licorice, reed root, honeysuckle, gardenia, dendrobium and seabuckthorn have been proven to have certain preventive and therapeutic effects. And a review was conducted on the mechanism of action of the medicine-food herbs in the prevention and treatment of alcoholic liver disease at home and abroad in recent years, in order to provide ideas and references for the development of the medicine-food herbs with sobering and liver protecting effects, as well as drugs for the treatment of alcoholic liver disease.

References

National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association, and Fatty Liver Expert Committee, Chinese Medical Doctor Association." 34.05(2018): 939-946.

SINGAL A K, MATHURIN P. Diagnosis and treatment of alcohol-associated liver disease: a review[J]. J Am Med Assoc, 2021, 326(2): 165.

SARIN SK, KUMAR M, ESLAM M, et al. Liver diseases in the Asia-Pacific region: a lancet gastroenterology & hepatology commission [J]. Lancet Gastroenterol Hepatol, 2020, 5(2): 167.

LI Y M, FAN J G. Guidelines of prevention and treatment for alcoholic liver disease (2018, China) [J]. J Dig Dis, 2019, 20(4): 174.

HAN Li; RAO Zhi; CAO Lin, et al. Research Progress on Protective Effect of Medicinal Food Homology Foods on Alcoholic Liver Disease[J]. Food and Nutrition in China, 2023, 29(02):57-62.

ZHENG C Y, DAI X F, CHEN L N. Exploration of the medicinal and food efficacy of Pueraria Mirifica and its modern application [J/OL]. China Modern Chinese Medicine, 1-12[2024-10-15].

WANG S S. Protective effect of Pueraria lobata extract on mice with alcoholism[D]. Dalian University of Technology, 2019.

Li R, Liang T, He Q, et al. Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting hepatoprotection against chronic alcohol-induced liver injury in rats. Int Immunopharmacol, 2013, 17(1): 71-78.

Chen X, Li R, Liang T, et al. Puerarin improves metabolic function leading to hepatoprotective effect in chronic alcohol-induced liver injury in rats. Phytomedicine, 2013, 20(10): 849-852.

LI X. Exploring the Preventive Effects and Mechanisms of Pueraria lobataActive Ingredients Against Iron Overload in Mice with Alcoholic Liver Disease Based on Network Pharmacology and Animal Experiments [D]. Dali University, 2024.

YE L Y, MENG G L, WU L Y, et al. Metabolome analysis of Ganoderma lucidum fruiting body polysaccharides for the prevention of acute alcoholic liver injury in mice[J]. Mycosystema, 2021, 40(9): 2376-2389.

ZHANG R B, YANG Y H, LI C X, et al. Research progress on pharmacological effects and mechanisms of Ganoderma lucidum polysaccharides [J]. Natural Product Research and Development, 2023, 35(5):879- 887.

ZHAO T T, DAI Y D, SHU F, et al. Optimization of Ganoderma lucidum mycelium polysaccharide extraction process and its protective effect on chronic alcoholic liver injury[J]. Science and Technology of Food Industry, 2023, 44(5):388-396.

SUN Yanhui; ZHANG Hongbo. Effects of Ganoderma Polysaccharide on Liver Fat Deposits and NLRP3 Inflammatory Corpuscle Expression of Mice with Acute Liver Injury[J]. World Chinese Medicine, 2020, 15(06): 842-845.

MA B J. Protective effect and mechanism of ganoderic acid A on mice with acute alcoholic liver injury[D]. Zhengzhou: Zhengzhou University, 2019.

CAO Y J, HUANG Z R, YOU S Z, et. al. The protective effects of ganoderic acids from Ganoderma lucidum fruiting body on alcoholic liver injury and intestinal microflora disturbance in mice with excessive alcohol intake[J]. Foods, 2022, 11(7):949-956.

LUO Qun1, JIN Hongyu, YANG Jianbo, et al. JIANG G Y. Protective effect of goji berry water extract on acute alcoholic liver injury [D]. Yinchuan: Ningxia University.

WEI F F, WANG WJ, HE QH, et al. Protective effect and mechanism of goji berry polysaccharide on alcoholic liver injury in mice [J]. Pharmacological Evaluation Research, 2019, 42(5): 852-857

JIA D S, CUI S Z, XIE X L, et al. Protective Effect of Anthocyanin from Black Wolfberry on Alcoholic Liver Injury[J]. Food Research and Development, 2017, 38(12):166-168.

LI D. Study on the intervention and tissue differential expression of aerobic exercise and black citrus flavonoids in mice with alcoholic liver injury based on NF-κB pathway[D]. Changsha: Hunan Normal University, 2018.

ZHANG Fenfen; CHENG Mengdi; ZHOU Shanshan, et al. Repair effect of liquiritin on liver injury in mice with acute alcohol inundation[J]. Journal of Fuyang Normal University: Natural Science, 2021, 38(2):69-72, 84.

LU Peng-xin, JI Yu-hua, CUI Ting, et al. Research Progress on Chemical Constituents and Pharmacological Effects of Phragmitis Rhizoma and Predictive Analysis of Quality Markers[J/OL]. Modern Chinese Medicine, 1-16[2024-10-14].

RAO Zhi, CHEN Guang-yu1, XIE Meng-zhouStudy, et al. on the Protective Effect of Rhizoma Phragmitis Extracts on Acute Alcoholic LiverInjury in Rats [J]. LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH, 2022, 33(01):95-98.

LIU Chang1, DING Jing-xin1, ZHOU Yingy, et al. Protective effects of Lonicerae Japonicae Flos against acute alcoholic liverinjury in rats based on network pharmacology[J]. Chinese Journal of Traditional Chinese Medicine, 2021, 46(17):4531-4540.

WU Jinhong1, OUYANG Linqi, OUYANG Ting, et al. Research progress on mechanism of Zhizi (Gardeniae Fructus) intreating liver diseases[J]. Journal of Hunan University of Traditional Chinese Medicine, 2024, 44(07):1346-1350.

QI Leyuan, ZHANG Fengbo, XIAO Richuan, et al. Protective effect of Gardenia oil against alcohol-induced acute hepatic injury in mice[J]. China Oils and Fats, 2018, 43(8):76-80.

Wang J, Zhang Y, Liu R, et al. Geniposide protects against acute alcohol-induced liver injury in mice via up-regulating the expression of the main antioxidant enzymes [J]. Can J Physiol Pharmacol, 2015, 93(4): 261-267.

Wei J, Man Q, Ding C, et al. Proteomic investigations of transcription factors: critical role of geniposide - mediated suppression of alcoholic steatosis and overdose-induced hepatotoxicity on liver in rats [J]. J Proteome Res, 2019, 18(11): 3821-3830.

YAO Jing, LIU Cuiling, SUN Hui, et al. Study on the Protective Effects of Fresh Dendrobium huoshanense C. Z. Tang et S. J. Cheng on Chronic Alcoholic Liver Disease in Mice[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2023, 34(06):764-770.

TANG Wei-wei, ZHANG Yu, WANG Yu-liang, et al. Preparation and Alcohol Detoxication Activities of the Sulfated Hippophae rhamnoides L. Leaf Polysaccharide [J]. Food Research and Development, 2019, 40(17): 47-51.

DENG Bin, CHEN Jie, LI Xiang, et al. Exploring the Mechanism of Action of Sea Buckthorn in the Treatment of Alcoholic Liver Injury Based on Network Pharmacology [J]. Science and Technology of Food Industry, 2024, 45(14):25-33.

CUI Chen, ZHANG Chen-rui, LI Sha, et al. Research Progress in the Active Substances and Its Processing and Utilization of Mulberry[J]. Food Research and Development, 2023, 44(03):208-213.

XIAO Ting, GUO Zhenghong, LUO Guangjia, et al. Effects of different berry extracts on chronic alcoholic liver disease in mice[J]. Journal of Guizhou Medical University, 2021, 46(09):1018-1023+1030.

BIAN Liang. Pharmacodynamic re-evaluation and mechanism of Mori Fructus polysaccharide MFPA1 and MFPB1 against acute alcoholic liver injury[D]. Guizhou Normal University, 2021.

LI Wen-li, ZHOU Yu-jia. YANG Li-li. Effects of Cyanidin-3-O-Glucoside Extracted from Mulberry on Ethanol-Induced Liver Injury and Mortality of Mice[J]. Food and Nutrition in China, 2022, 28(07):34-40.

CHANG Luli. The Extraction and Purification Method of Hawthorn Flavonoids and the Effect of Hawthorn Flavonoids on Alcoholic Live[D]. Zhengzhou University, 2010.

WEI Lei, WEI Qianqian, LI Siwe, et al. Effects of maslinic acid on partial biochemical indexes in mice with acute alcoholic liver injury[J].Clinical Research and Practice, 2020, 5(33):4-6.

YAN S L, YANG H T, LEE H L, et al. Protective effects of maslinic acid against alcohol-induced acute liver injury in mice[J]. Food and Chemical Toxicology, 2014, 74:149-155.

Downloads

Published

2024-10-29

How to Cite

Wang, X., & Xin, B. (2024). Research Progress of the Medicine-food Herbs Against Alcoholic Liver Disease. Journal of Contemporary Medical Practice, 6(10), 85–90. https://doi.org/10.53469/jcmp.2024.06(10).17