Overview of the Mechanism of Action of Gentiana Scabra in the Treatment of Rheumatoid Arthritis
DOI:
https://doi.org/10.53469/jcmp.2024.06(09).06Keywords:
Gentiana macrocephala, Rheumatoid arthritis, Mechanism of action, Compounding, ReviewAbstract
Objective: To provide a comprehensive review of the research on the analgesic, anti-inflammatory, anti-swelling and analgesic effects of Radix Gentiana Macrophylla. Methods: Gentiana macrocephala has an analgesic effect in modern research, commonly used in various rheumatism and paralysis, numbness, contracture and soreness of the muscles and bones and other diseases of the pain treatment, can be extracted from the sterol glycoside salts and other medicinal components, its anti-inflammatory and analgesic and treatment of acute arthritis episodes of the clinical effect of the performance of the particularly unique and significant. The results can make the joint swelling, pain and other symptoms can be reduced, and the risk of reoccurrence can also be reduced after the introduction of the drug. Conclusion: In the treatment of rheumatoid arthritis, Gentiana Macrophyllae alone and in combination can improve joint symptoms such as stiffness, swelling, pain, distension and deformity as well as other systemic symptoms of rheumatoid arthritis.
References
MA Tengmao, LIU Fei, WANG Rong, WU Guotai, GAO Huiqin. Effects of different combinations of Radix Gentiana scabra on analgesic effect and serum TNF - α, IL - 1β, PGE2 in rats with rheumatic fever paralysis rheumatoid arthritis model[J]. Liaoning Journal of Chinese Medicine, 2017, 39(1):11-15.
Pang Xuefeng, Meng Yuhua. Treatment of 86 cases of rheumatoid arthritis by expelling wind and removing paralysis capsule[J]. Shaanxi Traditional Chinese Medicine, 2002, 23(12):1073-1075.
ZHAO Weigang. Treatment of rheumatoid arthritis with methotrexate and diclofenac sodium in 36 cases[J]. Rheumatism and Arthritis, 2013, 2(6):15-16, 30.
Xiao Wei, Mao Huihui, Zhang Xianjian, et al. Observation on clinical efficacy of external application of Xinzhuang tablet combined with western medicine in the treatment of gouty arthritis. Shizhen Guomao Guomao, 2017, 28(5): 137-138.
LANG Yu-Ying, WANG Bin. Study on the effect of Gentiana scabra extract on adjuvant arthritis in rats. Chinese Traditional Medicine Science and Technology, 2012, 19(5): 409-409.
Wei R P, Sun F L, Ai H X, et al. Progress in the study of anti-inflammatory effects and mechanisms of gentianoside [J]. Chinese Journal of Pharmacology and Toxicology, 2014, 28(4): 678-679.
Zhang Xinxin, Jia Na, Sun Chen, Zhao Wenna, Sun Wenji. Study on the anti-inflammatory paroxysmal effects of Macrophyllum macrocarpon flower and Sesbania macrophyllum flower[J]. Northwest Journal of Pharmacy, 2006, 12(9): 63- 64.
Li Jing. Clinical observation of 80 cases of frozen shoulder treated with small needle knife combined with macrophyte soup[J]. New Chinese Medicine, 2015, 47(4):247- 248.
Tian Delu. Internal medicine of traditional Chinese medicine [M]. Beijing: People's Health Publishing House, 2008: 370.
Wu Fenghai. Clinical observation on the treatment of rheumatoid arthritis by Gentiana Macrophylla Wuteng Drink[J]. Beijing: China Medical Science and Technology Press, 2018: 117- 119.
Jiang Shushu, Gao Zisan, Gan Junxue, et al. Progress of Th17- STAT3 positive feedback pathway in pro-inflammatory mechanism of rheumatoid arthritis[J]. Liaoning Journal of Chinese Medicine, 2015, 42(4):897- 901.
Huang Youhan, Zhu Jian, Lin Tianxu. Observation on the efficacy of Macrophyllum Gentianum Soup plus reduction in the treatment of acute gouty arthritis[J]. Journal of Traditional Chinese Medicine, 2013, 41(3): 115.
Niu Sailong, Sun Fuzeng, Zhang Xingnai. Anti-inflammatory effects of total cyclic enol ether terpene glycosides of Gentiana scabra and its mechanism [J]. Journal of Pharmacy Practice, 2013, 31(3): 198- 200.
Liu Weiwei, Zhang Fuqiang, Wu Xi, et al. Expression and clinical significance of miR-34a and miR-125b in peripheral blood mononuclear cells of rheumatoid arthritis patients. World Scientific Research and Development 2015, 37(3): 286-289.
Wang Guangming. Guo Xiaozhuang. Bai Rao. Combination of Chinese and Western medicine in the treatment of rheumatic diseases. Tianjin: Tianjin Science and Technology Press 1989:553.
TAN Yanjin, YANG Xiaofeng. Clinical efficacy and effect on serum inflammatory factor in rheumatoid arthritis treated with Tongpai Tang plus reduction combined with moxibustion[J]. World Journal of Integrative Medicine, 2020, 15(5):884-887+968.
ZHANG Yan, XU Qiong, CHEN Menglu. Efficacy and effect on joint function and inflammatory factors of DuoYu parasitic soup combined with leflunomide in the treatment of elderly rheumatoid arthritis[J]. Chinese Journal of Gerontology, 2019, 39(22):5569-5571.
ZHANG Shuhua, YANG Huiyong, ZHENG Chenna, et al. Correlation of IL-1, IL-10 and TNF-β single nucleotide polymorphisms with rheumatoid arthritis in the Han Chinese population in Quanzhou, Fujian[J]. Chinese Journal of Pathophysiology, 2020, 36(2): 354-359.
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