Advances in the Treatment of Diabetic Retinal Inflammatory Factors with Curcumin

Authors

  • Hongli Li Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Yanchun Zhang Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an 710004, Shaanxi, China

DOI:

https://doi.org/10.53469/jcmp.2024.06(08).36

Keywords:

Curcumin, Diabetic retina, Inflammatory factors, Traditional Chinese medicine treatment, Mechanisms

Abstract

Retinal vein occlusion (RVO) is one of the common retinal vascular diseases characterized by vascular obstruction leading to intraretinal RVO is one of the common retinal vascular diseases characterized by vascular obstruction leading to intraretinal hemorrhage, fluid exudation, and varying degrees of retinal ischemia, and its secondary macular edema (ME) is the main cause of visual impairment in patients. Retinal vein occlusion secondary to macular edema is a pathophysiological process involving multiple factors, with a complex pathogenesis and many cytokines involved, and a high degree of visual impairment in patients. and many cytokines involved, resulting in an imbalance of fluid into and out of the retina, which leads to the formation of ME. In recent years, with the development of molecular biology techniques, inflammatory factors associated with RVO-ME have become an important aspect in the study of RVO-ME. this article, we review the inflammatory factors associated with retinal vein occlusion secondary to macular edema and the pathogenesis of RVO-ME.

References

Yang Jian. Mechanism study of curcumin regulating autophagy through JNK signaling pathway to prevent diabetic retinopathy[D]. Jilin University, 2022.

You Yuhong. Study on the protective effect of curcumin on early retinal changes in diabetic rats[D]. Soochow University, 2021.

Ran ZL. Regulatory effects of curcumin on PI3K/Akt/mTOR pathway in diabetic retinopathy[D]. Hebei Medical University, 2018.

Leilei Wang. Mechanism study of inflammation occurrence in retinal injury[D]. Wuhan University,2013.

Gu Xuejing; Zuo Zhongfu. Protective effects of curcumin on retinal Müller cells in early diabetic rats[J]. New Progress in Ophthalmology, 2013, 33(03):233-235.

LI Na; ZHANG Hailin; LI Xiufen; DONG Yannan. Research progress on inhibition of SphK1-S1P pathway by traditional Chinese medicine for the treatment of diabetic nephropathy[J]. Journal of Chinese Medicine, 2019, 34(06):1188-1192.

Gao Yuhan;Dong Zhijun. Research progress of inflammation-related factors in diabetic retinopathy[J]. Journal of Chengde Medical College, 2023, 40(03): 241-244.

Shi Shaoyang; Song Haisan; Bao Juan. Progress of curcumin in fundus retinal and optic neuropathy[J]. Medical Review, 2020, 26(20):4121-4126.

Zhang Q; He Longxi; Zheng X; Zhang Jian. Research progress on the antitumor effects of curcumin[J]. West China Journal of Pharmacy, 2023, 38(04):473-476.

WANG Xinxiao; DONG Wei; XU Xiqiang; LI Qiuxiang; ZHOU Aixian; LIANG Xinli. Progress of anti-inflammatory effects of curcumin on chronic inflammatory diseases[J]. Chinese Journal of New Drugs, 2023, 32(10):1028-1036.

HE Qiong; HE Jianzhong; LAI Wei; QIU Yanfei. Effect of curcumin on Ets-1 expression in the retina of diabetic rats[J]. Experimental and Laboratory Medicine, 2017,35(05):677-679+694.

Zhong Lifan. Curcumin inhibits intestinal inflammation in PD mice through SIRT1/NRF2 pathway[D]. Hainan Medical College, 2023.

Shou Xi Yuan. Study on the role of curcumin in liver injury in diabetic mice[D]. Hubei Institute of Science and Technology, 2023.

Saberi-Karimian M , Keshvari M , Ghayour-Mobarhan M ,et al.Effects of Curcuminoids on Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease: An Exploratory Randomized Controlled Trial[J]. Complementary Therapies in Medicine, 2020, 49:102322.

Heydari M , Khalili M R , Nowroozzadeh M H ,et al. Therapeutic Implications of Curcumin in the Treatment of Inflammatory Eye Diseases: A Review[J].Current pharmaceutical biotechnology, 2023, 24:553-561.

Nebbioso M , Franzone F , Greco A ,et al.Recent Advances and Disputes About Curcumin in Retinal Diseases[J]. Clinical Ophthalmology, 2021.

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Published

2024-08-21

How to Cite

Li, H., & Zhang, Y. (2024). Advances in the Treatment of Diabetic Retinal Inflammatory Factors with Curcumin. Journal of Contemporary Medical Practice, 6(8), 173–176. https://doi.org/10.53469/jcmp.2024.06(08).36