Overview of the Research Progress of Traditional Chinese Medicine in the Intervention of Kidney Deficiency and Blood Stasis Type Osteoporosis by Regulating the PI3K/Akt Signalling Pathway
DOI:
https://doi.org/10.53469/jcmp.2024.06(08).50Keywords:
Osteoporosis, Kidney deficiency and blood stasis, PI3K/Akt signalling pathway, Traditional Chinese medicine, ReviewAbstract
Osteoporosis (OP), as a chronic and complex metabolic bone disease, is centred on disturbances in the bone microcirculatory system, which exacerbates bone loss and damage to the microstructure of bone tissue, resulting in increased bone fragility. Typical clinical manifestations include persistent low back pain, a significant increase in fracture risk, and marked changes in spinal morphology, all of which have a serious impact on patients' quality of life. The incidence of osteoporosis (OP) is showing a year-on-year increase as the proportion of the elderly population continues to rise globally. Despite the success of Western medicines in the treatment of OP, the ensuing adverse effects and uncertainty of efficacy remain to be addressed. This has prompted the medical community to actively explore safer and more effective treatments. The field of Traditional Chinese Medicine (TCM) has demonstrated unique advantages in the treatment of osteoporosis. Notably the PI3K/Akt signalling pathway, as a key mechanism regulating bone metabolism and blood circulation, has received extensive attention in recent years. According to Chinese medicine, the pathogenesis of OP is closely related to kidney deficiency and blood stasis. Therefore, from the molecular mechanism of PI3K/Akt signalling pathway, we will discuss how Chinese medicine can establish and maintain a relatively stable "bone balance" between osteoblasts and osteoclasts through the regulation of this key pathway, promote the growth of trabecular number and thickness, and at the same time, reduce the separation of trabeculae, so as to improve the bone balance of patients with OP due to kidney deficiency and blood stasis. This will improve the symptoms and quality of life of OP patients with kidney deficiency and blood stasis.
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