Research Progress of Cuproptosis and Its Role in Osteoporosis

Abstract

Copper is an essential trace element in the human body, participating in various physiological processes. cuproptosis is a new regulatory of cell death, which is caused by the combination of copper ions with proteins in the tricarboxylic acid cycle, leading to the aggregation of Thiocyanate acylated proteins and the down-regulation of iron-sulfur cluster proteins, thus inducing protein toxic stress to cause cell death. It is a new type of death. As an important coenzyme factor, the functional disorder of copper is related to the pathological conditions of osteoporosis. This paper analyzes the between cuproptosis and osteoporosis from the perspective of copper metabolism, the mechanism of cuproptosis and the role of related genes in osteoporosis, providing for the diagnosis, treatment and research of osteoporosis.