Correlation Between Characteristic OCT Biological Parameters and Prognosis After Conbercept Therapy for Macular Edema Secondary to Retinal Vein Occlusion

Abstract

Objective: To investigate the correlation between characteristic optical coherence tomography (OCT) biological parameters, TCED-HFV classification, and visual prognosis in patients with macular edema secondary to retinal vein occlusion (RVO-ME) after conbercept treatment, so as to provide evidence for clinical diagnosis and treatment. Methods: A total of 60 patients with RVO-ME were enrolled and divided into four groups (15 cases each) according to the TCED-HFV classification. All patients received intravitreal injection of conbercept combined with a treat-and-extend (T&E) regimen and were followed up for 6 months. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and key OCT parameters were measured before and after treatment, followed by statistical analysis. Results: There were no significant differences in general clinical data among the four groups (P>0.05). After treatment, BCVA was significantly improved and CRT was significantly decreased in all groups (all P<0.05). The early-stage group achieved the best post-treatment BCVA, while the atrophic stage group had the worst baseline BCVA but the largest amplitude of BCVA improvement. CRT was positively correlated with visual improvement; the integrity of the ellipsoid zone (EZ) and external limiting membrane (ELM) were key indicators for visual prognosis prediction; the severity of disorganization of the inner retinal layers (DRIL) and hyperreflective foci (HF) was negatively correlated with prognosis. The TCED-HFV classification could accurately reflect the disease stage and treatment response. Conclusion: The intravitreal conbercept injection combined with T&E regimen is safe and effective for RVO-ME. The TCED-HFV classification and related OCT parameters can effectively predict the prognosis of RVO-ME patients, and early intervention can better protect visual function.