Research Status and Advancements in Post-Acute Pancreatitis Diabetes Mellitus

Abstract

Acute pancreatitis (AP), a common cause of acute abdominal pain in gastrointestinal disorders, is characterized by acute non-bacterial inflammation and acinar cell damage within the pancreas. As a heterogeneous disease, acute pancreatitis manifests as a condition with significant variations in presentation and disease progression. Diabetes of the exocrine pancreas (DEP), also termed pancreatogenic diabetes or type 3c diabetes mellitus (T3cDM), constitutes a secondary form of diabetes resulting from various exocrine pancreatic dysfunctions. This review summarizes the definition, diagnostic criteria, epidemiology, pathogenesis, risk factors, and current management strategies for Post-Acute Pancreatitis Diabetes mellitus (PPDM-A). Its objectives are to emphasize the clinical importance of post-discharge management for PPDM-A patients, facilitate effective preventive measures, enable early diagnosis and treatment, Reducing the incidence of PPDM-A and improving patients’ quality of life.