Research Progress of Traditional Chinese Medicine Regulating Notch Signaling Pathway in the Intervention of Gastric Cancer

Abstract

Gastric cancer is a highly invasive malignant tumor of the digestive system with a complex pathogenesis involving the activation of multiple signaling pathways. The abnormal activation of the Notch signaling pathway plays a key role in its occurrence and development, which promotes the proliferation, apoptosis, invasion and metastasis of gastric cancer cells and enhances the characteristics of cancer stem cells. Integrated traditional Chinese and Western medicine is the main therapeutic approach for gastric cancer in China. In recent years, an increasing number of scholars have taken the Notch signaling pathway as a starting point in the field of traditional Chinese medicine (TCM) for the prevention and treatment of gastric cancer, and carried out experimental studies on the regulation of the Notch signaling pathway by various TCM extracts, monomers and compound prescriptions. This paper collects and sorts out the relevant literatures on TCM regulating the Notch signaling pathway to exert the effect of preventing and treating gastric cancer in recent years, summarizes the mechanism of the Notch signaling pathway in gastric cancer, and analyzes the current research status, aiming to provide references for subsequent research and new drug development. However, the existing research is mainly based on basic experiments, and multi-center clinical studies are urgently needed to verify its translational value. This paper provides a theoretical basis and research direction for TCM targeting the Notch pathway in the treatment of gastric cancer.