Progress in the Study of Iron Death Induced in Hepatocellular Carcinoma Cells by Traditional Chinese Medicine and Its Active Ingredients
DOI:
https://doi.org/10.53469/jcmp.2024.06(07).10Keywords:
Herbal medicine, Herbal compounds, Hepatocellular carcinoma, Iron deathAbstract
The liver is the sixth most common site for primary cancers, but hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. Iron death is a novel programmed cell death mechanism involved in hepatocellular carcinoma cell death through multiple pathways, and modulation of iron death is a potential therapeutic option for hepatocellular carcinoma. In this paper, we reviewed herbal compounds inducing iron death in hepatocellular carcinoma cells through multiple pathways. These include iron metabolism pathway, lipid metabolism pathway, System XC-/GPX4/GSH pathway, and other pathways. Chinese medicines provide new ideas and directions for the treatment of hepatocellular carcinoma in traditional Chinese medicine (TCM) due to their natural sources and less side effects.
References
Aa A, Hm A, Fi A-J. Sorafenib[J]. Profiles of drug substances, excipients, and related methodology, Profiles Drug Subst Excip Relat Methodol, 2019, 44.
Huang Y, Wang S, Ke A, et al. Ferroptosis and its interaction with tumor immune microenvironment in liver cancer[J]. Biochimica Et Biophysica Acta. Reviews on Cancer, 2023, 1878(1): 188848.
Zhang Q, Zhao L, Xia P, et al. Progress in TCM Prevention and Treatment of Tumor Iron Death [J]. Clinical Journal of Traditional Chinese Medicine, 2021, 27(22):222-231.
Zhang H, Zhang Y, Fu J, et al. Active Ingredients of Chinese Medicines Induce Ferroptosis in Tumor Cells: A Review [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2023:1-13.
Dixon S J, Lemberg K M, Lamprecht M R, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5): 1060–1072.
Jiang X, Stockwell B R, Conrad M. Ferroptosis: mechanisms, biology and role in disease[J]. Nature Reviews. Molecular Cell Biology, 2021, 22(4): 266–282.
Wu Q, Chen Z, Ding Y, et al. Protective effect of traditional Chinese medicine on non-alcoholic fatty liver disease and liver cancer by targeting ferroptosis[J]. Frontiers in Nutrition, 2022, 9: 1033129.
Liang D, Minikes A M, Jiang X. Ferroptosis at the intersection of lipid metabolism and cellular signaling[J]. Molecular Cell, 2022, 82(12): 2215–2227.
Kagan V E, Mao G, Qu F, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis[J]. Nature Chemical Biology, 2017, 13(1): 81–90.
Liu J, Kang R, Tang D. Signaling pathways and defense mechanisms of ferroptosis[J]. The FEBS journal, 2022, 289(22): 7038–7050.
Tian K, Wei J, Wang R, et al. Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis[J]. Cell Death Discovery, 2023, 9(1): 296.
Chen G-Q, Benthani F A, Wu J, et al. Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis[J]. Cell Death and Differentiation, 2020, 27(1): 242–254.
You G. Role and mechanism of AMPK-mediated autophagy in strychnine-induced iron death in hepatocellular carcinoma [D]. Jilin University, 2023.
Su Y, Zhao D, Jin C, et al. Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15-LO[J]. Oxidative Medicine and Cellular Longevity, 2021, 2021: 3456725.
Qiu X, Jia L, Song N, et al. Study on Effect and Mechanism of Huayu Qutan Fomula on Mice with High-Fat and Liver Cancer Based on Ferroptosis Related Protein [J]. Chinese Archives of Traditional Chinese Medicine, 2021, 39(9):137-141.
Li Y, Zhang J, Zhang K, et al. Scutellaria barbata Inhibits Hepatocellular Carcinoma Tumorigenicity by Inducing Ferroptosis of Hepatocellular Carcinoma Cells[J]. Frontiers in Oncology, 2022, 12: 693395.
Lin P-L, Tang H-H, Wu S-Y, et al. Saponin Formosanin C-induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells[J]. Antioxidants (Basel, Switzerland), 2020, 9(8): 682.
Liu M, Cai Y, Chen Hao, et al. Study on the mechanism of iron death induced by ginsenoside CK in human hepatocellular carcinoma cells[J]. Lishizhen Medicine and Materia Medica Research, 2024, 35(03):554-559.
Ren S, Fan Y, Guo D, et al. Systematic evaluation and meta⁃analysis of the efficacy and safety of cinobufagin injection combined with western medicine in the treatment of liver cancer[J]. Journal of Hainan Medical University, 2023, 29(6):452-462.
Wu Q, Yang J, Chen Q, et al. Study on the mechanism of cinobufotalin in inducing ferroptosis of hepatoma cells by inhibiting the expression [J]. Journal of Pharmaceutical Research, 2024, 43(3):214-219235.
Cai X, Yang R, Wang Z, et al. Mechanism of Inducing Ferroptosis in Hepatocellular Carcinoma Cells by Shugan Quyu Jiedu Prescription Based on p53/SLC7A11/GPX4 Pathway [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2023:1-11.
Peng Y, Li N, Tang F, et al. Corosolic acid sensitizes ferroptosis by upregulating HERPUD1 in liver cancer cells[J]. Cell Death Discovery, 2022, 8(1): 376.
Liu J, Tong L, Luo Y, et al. Cryptotanshinone May Induce Ferroptosis of Human Liver Cancer HepG2 Cells [J]. Acta Academiae Medicinae Sinicae, 2021, 43(3):366-370.
Zhu Z-H, Xu X-T, Shen C-J, et al. A novel sesquiterpene lactone fraction from Eupatorium chinense L. suppresses hepatocellular carcinoma growth by triggering ferritinophagy and mitochondrial damage[J]. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 2023, 112: 154671.
Yao Y, Liu Y, Yang Y, et al. Regularity of traditional Chinese medicine regulating ferroptosis in intervention liver cancer based on bioinformatics. [J]. Journal of Guangxi University (Natural Science Edition), 2022, 47(1):235-244.
Li K. Exploration of the mechanism of action of solidifying and eliminating accumulation formula to intervene iron death in human hepatocellular carcinoma HepG2 cells based on the p62/Keap1/NRF2 pathway [D]. Hunan University of Chinese Medicine, 2022.
Jian H, Li K, Zeng P, et al. Effect of Shipi Xiaoji Beverage-containing Serum on Mitochondrial Dynamics Imbalance and Ferroptosis of Liver Cancer HepG2 Cells [J]. Journal of Traditional Chinese Medicine, 2024, 65(6):609-617.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Raoyan Tan, Gang Xiao, Hui Guo
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
