Clinical Efficacy and Mechanism Exploration of Rougan Jianpi Decoction in Treating IBS-D with Liver Depression and Spleen Deficiency Syndrome

Abstract

Objective: To observe the clinical efficacy and therapeutic mechanism of Rougan Jianpi Decoction in the treatment of IBS-D with liver depression and spleen deficiency type. Methods: A total of 120 patients with IBS-D who visited the Gastroenterology Department of Xi'an Affiliated Hospital of Shaanxi University of Chinese Medicine from August 2022 to September 2024 were selected as the research subjects. They were randomly divided into the experimental group and the control group. The control group was treated with pirenzepine tablets combined with Clostridium pasteurianum live bacteria tablets; The experimental group was treated with the Rougan Jianpi Decoction. After 4 weeks of treatment, the clinical efficacy, TCM syndrome scores, anxiety level, depression level, serum NPY level, inflammatory factor level, and adverse reaction occurrence of the two groups were compared. Results: The total effective rate of the experimental group (89.66%) was higher than that of the control group (78.95%) (P < 0.05); the reduction level of TCM syndrome scores in the experimental group was higher than that in the control group (P < 0.05); the reduction levels of Hamilton Anxiety Scale (HAMA) score and Hamilton Depression Scale (HAMD) score in the experimental group were higher than those in the control group (P < 0.05); the increase level of serum NPY in the experimental group was higher than that in the control group (P < 0.05); the decrease level of serum inflammatory factors in the experimental group was higher than that in the control group (P < 0.05); there was no statistically significant difference in the occurrence of adverse reactions between the two groups (P > 0.05). Conclusion: Rougan Jianpi Decoction can significantly improve the clinical symptoms of IBS-D patients with liver depression and spleen deficiency type. Its mechanism of action may be related to regulating the brain-gut axis function of patients and reducing the inflammatory response of the body.