Discussion on TCM Intervention Strategy for Diabetic Nephropathy Vascular Disease from the Perspective of Network Disease Theory

Abstract

As a severe microvascular complication of diabetes, diabetic nephropathy is closely associated with vascular pathologies. Root-and-network theory, originating from classical Chinese medical texts, posits that meridian networks serve as microscopic pathways for qi and blood circulation, where their dysfunction can trigger various chronic diseases. This study employs root-and-network theory to systematically analyze the pathological mechanisms of diabetic nephropathy’s vascular complications, proposing three key perspectives: meridian network obstruction, meridian network deficiency, and meridian network depletion. Integrating holistic TCM concepts and syndrome differentiation principles, we elaborate on therapeutic strategies including blood activation, meridian unblocking, tissue dispersion, and meridian qi supplementation. Clinical case analyses and experimental studies validate these interventions’ effectiveness in improving microcirculation, reducing vascular endothelial damage, and delaying disease progression. The findings aim to establish new theoretical foundations and practical guidelines for TCM-based treatment of diabetic nephropathy’s vascular manifestations.