Analyzing the Therapeutic Effect of Kidney Tonifying, Blood Activating and Knot Dispersing Formula in the Treatment of IgA Nephropathy based on “State-targeted Diagnosis”

Abstract

IgA nephropathy (IgAN), characterized by its unique deposition of immune complexes in the glomerular mesangial zone, is one of the most common primary glomerulonephritis worldwide. Clinical and pathological studies have found that IgAN is characterized by kidney deficiency and blood stasis, and the in-hospital preparation of tonifying the kidney, activating blood and dispersing knots approach has obvious therapeutic effects on IgAN with tubulointerstitial injury. In this paper, starting from the theory of “state-target identification” of academician Tong Xiaolin, we explored the characteristics of the formula of Kidney Tonifying Formula and analyzed its mechanism of action in treating IgAN by tonifying the state of kidney deficiency, resolving the state of blood stasis and combining with the results of the research on the pharmacology of traditional Chinese medicines for the purpose of precise targeting. It is concluded that the use of targeting and combination of formulas in the treatment of IgAN can better regulate the overall balance of the patient’s body and promote the recovery and reconstruction of renal function.