Research Progress on the Intervention of Recurrent Miscarriage by Regulating the P13K/AKT Signaling Pathway with Traditional Chinese Medicine

Abstract

Recurrent spontaneous abortion (RSA) is a common gynecological complication during pregnancy, characterized by recurrent spontaneous miscarriages. The incidence rate of the disease is increasing year by year, and the risk of recurrent miscarriage increases with the increase in the number of miscarriages, which seriously affects women’s physical and mental health. At present, targeted intervention after screening the causes is adopted as the treatment plan, but there are limited treatment options and high recurrence rates. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B(AKT) signaling pathway plays a central regulatory role in cell growth, proliferation, metabolism, and apoptosis, and is closely related to the occurrence and development of RSA. Traditional Chinese medicine has significant therapeutic effects in the prevention and treatment of RSA. It can regulate the PI3K/AKT signaling pathway, affecting the proliferation, invasion and migration of trophoblasts, placental angiogenesis, immune regulation, embryo implantation, etc., thereby maintaining pregnancy. This article extensively collects relevant literature published domestically and internationally, focusing on the regulation of the PI3K/AKT signaling pathway by traditional Chinese medicine to intervene in RSA. It systematically summarizes and organizes the active ingredients of traditional Chinese medicine, including flavonoids, alkaloids etc., as well as traditional Chinese medicine formulas such as Shoutai Wan, Taining Fang, and Zishen Yutai Wan, which can intervene in RSA by regulating the PI3K/AKT signaling pathway and interaction pathway, inhibiting cell apoptosis, promoting decidual angiogenesis, and improving placental interface angiogenesis. This article reviews the relevant research on the regulation of PI3K/AKT signaling pathway by traditional Chinese medicine in the intervention of RSA, in order to provide research ideas for the treatment of RSA with traditional Chinese medicine and lay the foundation for the development of new clinical drugs.