Review of the Interaction between Gut Microbiota and IL-17 in Diabetic Immune Inflammation

Abstract

The association between gut microbiota and host health has been increasingly recognized as research in this field progresses. This review is centered on the gut microbiome and its interplay with IL-17 in diabetes-associated immunoinflammatory disorders. Through a comprehensive examination of the composition, functional properties, and host-modulatory roles of gut microbiota, an analysis is conducted to elucidate how microbiota-derived perturbations are linked to IL-17 expression. The potential implications of this regulatory mechanism for the pathogenesis of diabetic immunoinflammatory conditions are further emphasized. These findings collectively demonstrate the bidirectional relationship between gut microbiota dynamics and IL-17-mediated inflammatory pathways, offering translational implications for diabetes immunotherapy development.