Gene DSCC1 is a Potential Biomarker in Pan-cancer

Abstract

Background: DNA replication and sister chromatid cohesion1 (DSCC1) is a component of the alternative replication factor C complex (RFC), which plays an important role in sister chromatid cohesion and regulates the cell cycle. DSCC1 is reported to have increased expression in tumor progression, but the underlying mechanisms of DSCC1 in tumor immunity remain obscure. Methods: Data were collected from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) project to obtain DSCC1 expression and clinicopathologically relevant data. Differential expression of DSCC1 and its association with prognosis, tumor microenvironment, immune infiltration, immune regulation, and genomic stability in various cancers were analyzed using R software. Results: The results of pan-cancer analysis showed that DSCC1 expression was elevated in 22 tumors. In 15 tumors, high expression of DSCC1 was observed to correlate with dismal overall survival. Furthermore, a correlation between DSCC1 expression and immune checkpoints was determined. In addition, DSCC1 expression was correlated with tumor-infiltrating immune cells, especially in Thymoma (THYM). Finally, gene set enrichment analysis (GSEA) demonstrated that DSCC1 is critically involved in tumor proliferation, immunity, and metabolism. Conclusions: High DSCC1 expression is found in many common tumors and is associated with poor prognosis. The gene is an essential factor in sister chromatid cohesion and may contribute to tumor progression by affecting the tumor immune microenvironment and genomic stability. DSCC1 has the potential to be a prognostic marker, and therapies targeting it may benefit patients.