The Pathogenesis and Treatment of Autoimmune Uveitis
DOI:
https://doi.org/10.53469/jcmp.2025.07(02).09Keywords:
Uveitis, Immunity, Traditional Chinese medicine, TreatmentAbstract
Uveitis is an inflammatory reaction that occurs in intraocular tissues. Among them, non-infectious uveitis is a T cell-mediated autoimmune inflammatory response, but its pathogenesis is not fully understood. This article reviews its pathogenesis and treatment progress.
References
Yang Peizeng, Zhang Zhen, Wang Hong, et al. Studies on the etiologies and classification of uveitis [J]. Chinese Journal of Ocular Fundus Diseases, 2002(4).
Zhou Qin, Yan Ying, Zhang Yan. Research progress of ophthalmic immunology [J]. International Eye Science, 2010, 10(5): 918-920.
Hou S, Du L, Lei B, et al. Genome-wide association analysis of vogt-koyanagi-harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3 [J]. Nature Genetics, 2014, 46(9): 1007-1011.
Chi W, Yang P, Li B, et al. IL-23 promotes CD4+ T cells to produce IL-17 in vogt-koyanagi-harada disease [J]. Journal of Allergy and Clinical Immunology, 2007, 119(5): 1218-1224.
Yang Peizeng, Du Liping. Research progress of uveitis in China [J]. Chinese Journal of Ophthalmology, 2019, 55(4): 5.
Xiong Hui, Yang Mingming, Yu Xuhui. Role of complement system in the pathogenesis of uveitis [J]. International Eye Science, 2022, 22(8): 1293-1297.
Yang Shufang, You Caiyun. Research advances in interleukin-35 for the treatment of non-infectious uveitis [J]. Recent Advances in Ophthalmology, 2022, 42(3): 249-252.
Meng Q, Yang P, Guo H, et al. Characteristic expression of PD-1 and its ligands mRNAs in patients with noninfectious uveitis [J]. International Journal of Clinical and Experimental Medicine, 2016, 9(1): 323-329.
Chen J, Qian H, Horai R, et al. Mouse models of experimental autoimmune uveitis: comparative analysis of adjuvant-induced vs spontaneous models of uveitis [J]. Current Molecular Medicine, 2015, 15(6): 550-557.
Lee D J, Taylor A W. Recovery from experimental autoimmune uveitis promotes induction of antiuveitic inducible tregs [J]. Journal of Leukocyte Biology, 2015, 97(6): 1101-1109.
YANG Chenling, ZHOU Huifang. Research progress on the role of PD-1/PD-L1 pathway in autoimmune eye diseases [J]. Journal of Shanghai Jiaotong University (Medical Science), 2022, 42(1): 107-112.
Chan Zhao, Meifen Zhang. Immunosuppressive treatment of non-infectious uveitis: history and current choices [J]. Chinese Medical Sciences Journal, 2017, 32(1): 48-61.
Zhang Yuqing, Shao Yi, Zhou Qiong. Progress in systemic treatments of non-infectious uveitis [J]. International Eye Science, 2019, 19(12): 2045-2047.
Xu Xinyue, He Wei. Recent research progress on treatment of traditional Chinese medicine for uveitis [J]. Journal of Practical Traditional Chinese Internal Medicine, 2021, 35 (05): 133-136.
Wang Shanshan, Tang Xiaoting, Li Xueting. Research progress in the mechanism of traditional Chinese medicine in the treatment of uveitis [J]. Asia-Pacific Traditional Medicine, 2021, 17 (11): 213-216.
Yu Jiazhen, Mo Ya. New progress in the treatment of uveitis by extracts of traditional Chinese medicine [J]. Journal of Chinese Ophthalmology and Otorhinolaryngology, 2021, 11 (02): 93-97.
Zou Taoyuan, Ning Yunhong, Guo Chengwei. Mechanism of Shaoyao Gancao Decoction against uveitis: based on network pharmacology and experimental verification [J]. World Chinese Medicine, 2022, 17 (08): 1064-1070.
LYU Lu, Ning Yunhong, Guo Chengwei. Effects of Shaoyao Gancao Decoction on experimental autoimmune uveitis rats guided by translational medicine approach [J]. Journal of Shandong University of Traditional Chinese Medicine, 2018, 42(3): 255-258.
Yin Xuewei, Liu Bin, Wei Huixia, et al. Inhibitory role of longdanxiegan decoction in the activation of notch signaling pathway in treating experimental autoimmune uveitis rats [J]. Recent Advances in Ophthalmology, 2019, 39(7): 615-619.
Xiang Shengjin, Wang Yuqin, Li Yan, et al. Effect of Longdan-xiegan Capsule on the levels of cytokine in patients with positive HLA-B27 acute anterior uveitis. [J]. Journal of Medical Research, 2013, 42(1): 58-61.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Wang Pan, Furong Pan, Yanrui Dong, Jing’an Tong
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
