Research Progress on the Treatment of Ischemic Stroke by Regulating the Sonic Hedgehog Signaling Pathway with Traditional Chinese Medicine
DOI:
https://doi.org/10.53469/jcmp.2025.07(01).34Keywords:
Chinese herbal medicine, Ischemic stroke, Shh signaling pathway, ReviewAbstract
Ischemic stroke (IS) is a series of pathological damages caused by the interruption of local cerebral blood flow. Its pathogenesis is extremely complex, involving multiple signaling pathways. Among them, the Sonic Hedgehog (Shh) signaling pathway has become a research hotspot in recent years. IS falls into the category of "apoplexy". Apoplexy is also known as stroke. Traditional Chinese medicine (TCM) has a long history in treating apoplexy. The comprehensive treatment methods of TCM mainly focus on syndrome differentiation and treatment. According to the changes of syndromes in different periods of apoplexy, treatment is carried out according to the syndrome. Chinese herbal medicine is inexpensive and has multiple targets of action. Based on the above background, this study investigates how Chinese herbal medicine alleviates the damage caused by IS by regulating the Shh signaling pathway, and points out its shortcomings, providing favorable conditions for subsequent research.
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