Progress of Research on Chinese Medicine Intervention in Ferroptosis for Osteoarthritis
DOI:
https://doi.org/10.53469/jcmp.2025.07(01).30Keywords:
Osteoarthritis, Ferroptosis, Chinese medicineAbstract
Osteoarthritis is a common chronic joint disease that brings great pain and life burden to patients. In recent years, ferroptosis, a novel mode of programmed cell death, has gradually gained attention in the pathogenesis of osteoarthritis. As a traditional treatment method, Chinese medicine has the advantages of multi-targeting and overall regulation in regulating ferroptosis in osteoarthritis. This review discusses the mechanisms of TCM in regulating ferroptosis-related signaling pathways, anti-oxidative stress, inhibition of inflammatory responses, and the key regulators and regulatory pathways of ferroptosis in osteoarthritis, and comprehends the current status of the research on the targeting of active ingredients of TCM to inhibit ferroptosis, so as to provide reference for the research on the mechanism of TCM in treating osteoarthritis and for the research and development of drugs.
References
Joint Surgery Group of Chinese Orthopaedic Association, Osteoarthritis Group of Orthopaedic Association of Chinese Physicians Association, National Clinical Research Center for Geriatric Diseases (Xiangya Hospital), et al. Osteoarthritis diagnosis and treatment guidelines in China (2021 edition) [J]. Chinese Journal of Orthopaedics, 2021, 41 (18): 1291 - 1314.
COURTIES A, KOUKI I, SOLIMAN N, et al. Osteoarthritis year in review 2024: Epidemiology and therapy [J]. Osteoarthritis Cartilage, 2024, 32 (11): 1397-404.
TANG D, CHEN X, KANG R, et al. Ferroptosis: molecular mechanisms and health implications [J]. Cell Res, 2021, 31 (2): 107-25.
XL L, GY Z, R G, et al. Ferroptosis in sepsis: The mechanism, the role and the therapeutic potential [J]. Front Immunol, 2022, 13: 956361.
DIXON S J, LEMBERG K M, LAMPRECHT M R, et al. 2012. Ferroptosis: an iron-dependent form of nonapoptotic cell death [J]. Cell, 149: 1060-1072.
LI J, CAO F, YIN H L, et al. Ferroptosis: past, present and future [J]. Cell Death Dis, 2020, 11 (2): 88.
KAGAN V E, MAO G, QU F, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis [J]. Nat Chem Biol, 2017, 13 (1): 81-90.
XUE Q, YAN D, CHEN X, et al. Copper-dependent autophagic degradation of GPX4 drives ferroptosis [J]. Autophagy, 2023, 19 (7): 1982-96.
XIE Y, KANG R, KLIONSKY D J, et al. GPX4 in cell death, autophagy, and disease [J]. Autophagy, 2023, 19 (10): 2621-38.
JIANG X, STOCKWELL B R, CONRAD M. Ferroptosis: mechanisms, biology and role in disease [J]. Nat Rev Mol Cell Biol, 2021, 22 (4): 266-82.
YANG W S, SRIRAMARATNAM R, WELSCH M E, et al. Regulation of ferroptotic cancer cell death by GPX4 [J]. Cell, 2014, 156 (1-2): 317-31.
MIAO Y, CHEN Y, XUE F, et al. Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression [J]. EBioMedicine, 2022, 76: 103847.
YAO X, SUN K, YU S, et al. Chondrocyte ferroptosis contribute to the progression of osteoarthritis [J]. J Orthop Translat, 2021, 27: 33-43.
HE Q, YANG J, PAN Z, et al. Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis [J]. Biomed Pharmacother, 2023, 157: 113915.
CUI T, LAN Y, YU F, et al. Plumbagin alleviates temporomandibular joint osteoarthritis progression by inhibiting chondrocyte ferroptosis via the MAPK signaling pathways [J]. Aging (Albany NY), 2023, 15 (22): 13452-70.
RUAN H, ZHU T, WANG T, et al. Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model [J]. Int J Mol Sci, 2024, 25 (13).
Wang H, Zhou F, Zhu R, et al. Effects of quercetin on Erastin-induced ferroptosis in chondrocytes [J]. Chinese Pharmacological Bulletin, 2024, 40 (10): 1945-1952.
LUO H, ZHANG R. Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the Xc-/GPX4 axis [J]. Exp Ther Med, 2021, 21 (1): 72.
XIAO J, LUO C, LI A, et al. Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling [J]. Int Immunopharmacol, 2024, 133: 112010.
DENG W, ZHANG W, HE Q. Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics [J]. Naunyn Schmiedebergs Arch Pharmacol, 2024, 397 (2): 959-68.
Shan J, Ye R, Ju S, et al. Mechanism underlying the effect of formononetin on interleukin-1beta-induced chondrocyte injury [J]. Chinese Journal of Tissue Engineering Research, 2025, 29 (12): 2484-2491.
He P, Li X, He Z, et al. Study on mechanism of action of biochanin A on osteoarthritis in vitro [J].J REG ANAT OPER SURG, 2024, 33 (09): 753-758.
LIU J, ZHOU H, CHEN J, et al. Baicalin inhibits IL-1β-induced ferroptosis in human osteoarthritis chondrocytes by activating Nrf-2 signaling pathway [J]. J Orthop Surg Res, 2024, 19 (1): 23.
Meng X, Salidroside and its metabolite tyrosol alleviate osteoarthritis by inhibiting chondrocyte ferroptosis [D]. Hubei Medical College, 2024. DOI:10.27913/ d.cnki.ghyby.2024.000220.
Ren W, Jiao Y, Zhang J, et al. Protective effect of cordycepin on osteoarthritis in rats [J]. Chin J New Drugs Clin Rem, 2024, 43 (10): 784-789.
Zhou F, Wang H, Zhu R, et al. The protective effect and mechanism of Taraxasterol on Erastin induced ferroptosis in chondrocytes [J]. Acta Universitatis Medicinalis Anhui,2024, 59 (06): 1053-1059.
Zhang J, Yan Y, Wang X, et al. Geniposide Regulates TLR4/MyD88/NF-κB Signaling Pathway to Alleviate Inflammatory Response in Rats with Knee Osteoarthritis [J/OL]. Pharmacology and Clinics of Chinese Materia Medica, 1-11 [2024-12-22].
Chen F. The role and mechanism of Prdx6 contributes to curcuminreduced osteoarthritic chondrocyte ferroptosis by the ROS-ASK1 signaling axis [D]. Anhui Medical University, 2023. DOI:10.26921/d.cnki.ganyu. 2023. 001782.
ZHOU Y, JIA Z, WANG J, et al. Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2 [J]. Heliyon, 2023, 9 (10): e20163.
Wang K, Ye H. Effect and its mechanism of emodin on the ferroptosis of chondrocytes in rats with knee osteoarthritis [J]. Tianjin Med J, 2023, 51 (10): 1090-1097.
XU J, ZHI X, ZHANG Y, et al. Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis [J]. Open Life Sci, 2023, 18 (1): 20220666.
MO Z, XU P, LI H. Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis [J]. Bioengineered, 2021, 12 (2): 9332-40.
He R. Study on the effect of Gubi Zhitong formula on regulating serum metabolite α-ketoglutarate to inhibit ferroptosis to alleviate osteoarthritis [D]. Changchun University of Chinese Medicine, 2024. DOI:10.26980/ d.cnki.gcczc.2024.000824.
Shen Jintao, Hua Maoqi, Zhang Bei, et al. Study on the Effect of Yangxue Roujin Formula Drug-containing Serum on IL-1β-Induced Iron Death of Rats Degenerated Chondrocytes Based on Akt/ Nrf2 / GPX4 Signaling Pathway [J/OL]. Journal of Chinese Medicinal Materials, 2024, (07): 1793-1799 [2024-12-23].
Xu L, Dong D, Wang Y, et al. Duhuo Jisheng Decoction Inhibiting Ferroptosis of Hondrocytes by Regulating miR-214-3p [J]. ACTA CHINESE MEDICINE, 2024, 39 (12): 2487-2492.
Dong J, Tian Y, Wang X, et al. Study ofthe Duhuo Jisheng Decoctionin Delaying Cartilage Degeneration of Knee Osteoarthritis in Rats by Regulatingthe ChondrocyteFerroptosisActivationEffec [J]. ChineseJTradMedTraum & Orthop, 2024, 32 (05): 9-13+17.
Liao S, Ma Z, Xing R, et al. Effects of Xibining II Prescription on knee osteoarthritis chondrocytes ferroptosis and Nrf2/GPX4 signaling pathway [J]. CJTCMP, 2024, 39 (10): 5182-5188.
Yang J, Peng L, Mao T, et al. Effects of Bushen Huoxue Formula on chondrocyte apoptosis in rats with osteoarthritis based on JNK pathway [J]. Journal of Hunan University of Chinese Medicine, 2024, 44 (09): 1575-1582.
Duan H, Zeng F, Wang L, et al. Mechanism of Taohong Siwu Decoction in Regulating Ferroptosis Mediated by Nrf2/Keap1/HO-1 Signaling Pathway in Knee Osteoarthritis [J]. Pharmacology and Clinics of Chinese Materia Medica, 2024, 40 (07): 10-15.
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