Research Progress on the Mechanism of Action of Tanshinone ⅡA in the Prevention and Treatment of Osteoarthritis
DOI:
https://doi.org/10.53469/jcmp.2025.07(01).28Keywords:
Tanshinone ⅡA, Osteoarthritis, Chondrocytes, Mechanism of actionAbstract
Osteoarthritis (OA) is a chronic inflammatory degenerative disease that is difficult to cure due to its complex pathogenesis. Traditional Chinese Medicine (TCM), with its multi-component, multi-target, and multi-pathway characteristics, offers various mechanisms for the treatment of OA. Tanshinone ⅡA (Tan ⅡA), a primary active ingredient extracted from the herb Salvia miltiorrhiza (Danshen), has shown significant potential in the treatment of OA. Tan II A can participate in the development of OA by activating or inhibiting multiple signaling pathways. It has various effects, including the inhibition of chondrocyte apoptosis and degradation of the extracellular matrix, reduction of inflammatory factor production, promotion of chondrocyte autophagy, and antioxidative stress. This review summarizes the role and mechanisms of Tan II A in the prevention and treatment of OA, providing a theoretical basis for future research and clinical applications of Tan ⅡA in OA treatment.
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