Neo4j-Based Analysis of Traditional Chinese Medicine Clinical Patterns Used to Treat Irritable Bowel Syndrome

Abstract

Objective: To apply Neo4j to construct a knowledge graph to explore the medication pattern of clinical treatment of irritable bowel syndrome, and to provide a new basis for the treatment of irritable bowel syndrome by Chinese medicine. Methods: By searching, collecting and screening the clinical type of literature on Chinese medicine treatment of irritable bowel syndrome in the database of China Knowledge Network in the past 5 years, using the prescriptions that meet the criteria in these literatures to establish an Excel database, and then applying the PHP 5.4 program code to the statistics of evidence type, frequency of Chinese medicine, frequency of use of Chinese medicine, as well as Chinese medicine operation. The final results were visualized using Javascript with the Echarts v5.3.2 drawing plug-in. A total of 298 valid data were included, of which the IBS-D high-frequency syndrome was liver depression and spleen deficiency, and the use of Chinese medicines was mainly based on spleen-strengthening medicines, Rhizoma Atractylodis Macrocephalae and Poria cocos ranked the first in terms of the “pairwise correlation”, while the IBS-C high-frequency syndrome was liver depression and Qi stagnation, and the use of Chinese medicines was mainly based on regulating Qi, and the highest “pairwise correlation” was Hojiblasta chinensis and Radix Angelicae Sinensis. Hovenia Citri reticulatae and Angelica sinensi had the highest “pairwise correlation”. Conclusion: Irritable bowel syndrome (IBS) is centered on liver stagnation, and the main principle of treatment is to regulate qi and dredge the liver.