Research Progress of Repetitive Transcranial Magnetic Stimulation in Limb Rehabilitation in Patients with Stroke and Hemiplegia

Authors

  • Zhen Yang School of Nursing, Beihua University, Jilin 132013, Jilin, China
  • Chunli Mei School of Nursing, Beihua University, Jilin 132013, Jilin, China
  • Mengyao Zhou School of Nursing, Beihua University, Jilin 132013, Jilin, China
  • Rili Mu School of Nursing, Beihua University, Jilin 132013, Jilin, China
  • Shuangyuan Song School of Nursing, Beihua University, Jilin 132013, Jilin, China

DOI:

https://doi.org/10.53469/jcmp.2025.07(01).23

Keywords:

Repetitive transcranial magnetic stimulation, Hemiplegia, Rehabilitation, Overview

Abstract

Stroke, also known as cerebrovascular accident. It is a cerebrovascular disease caused by damage or rupture of cerebral blood vessels, resulting in vascular failure and interruption of blood flow, resulting in cerebral cell ischemia and hypoxia. This kind of injury usually causes local brain dysfunction, and the symptoms last for more than 24 hours, which can lead to death in severe cases. Repetitive transcranial magnetic stimulation (rTMS) is widely used in the field of stroke rehabilitation of the upper extremities, but it is rarely described in the literature of the lower extremities. In order to overcome these problems, the challenges we must face in the future are to determine the best parameters and the most appropriate intervention time through a large number of clinical research centers, so as to provide patients with the best treatment plan in combination with the unity of the curative effect after intervention in various periods and various rehabilitation treatment methods.

References

Huang Xiaolin. Practical Rehabilitation Medicine (fine) [M]. People's Health Publishing House, 2009.

Wang Longde (Report on stroke prevention and treatment in China Writing Group. Brief report on stroke prevention and treatment in China, 2020[J]. Chinese Journal of Cerebrovascular Diseases, 2022, 19(2): 136-144.

Xiong Wenjing, Zhang Min, Xu Jieru, et al. Trend and age-period-queue analysis of stroke in China, 1990-2019[J]. Chinese Journal of Disease Control, 2023, 27(4):482-488.

Wu Yi. Research progress on the clinical application and mechanism of repeated transcranial magnetic stimulation in stroke rehabilitation[J]. Chinese Journal of Rehabilitation Medicine, 2023, 38(2):147-150

Zhao Jun, Zou Renling, Xu Xiulin, et al. The Research Status of Lower Limb Rehabilitation Training Method [J]. Progress in Biomedical Engineering, 2014, 35(2):5.

Huang-Li Lin, Ying-Zu Huang. Application of repetitive transcranial magnetic stimulation to the regulation of neuroplasticity in neurological and mental diseases [J]. Journal of the Physical Therapy Society, 2014, 39(1):10-17.

Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex[J]. Lancet, 1985, 1(8437): 1106-7.

Zhou Zhiqing, Shan Chunlei. Research progress of acupuncture therapy combined with repeated transcranial magnetic stimulation in stroke rehabilitation [J]. Chinese Journal of Rehabilitation, 2021, 36 (4): 239-244.

Zhu Ping, Zhong Yanbiao, Xu Shutian, et al. Research progress on the mechanism of repetitive transcranial magnetic stimulation of different paradigms and the improvement of post-stroke motor function[J]. Chinese Journal of Rehabilitation, 2019, 34(11):5.

Fitzgerald P B, Fountain S, Daskalakis Z J. A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition[J]. Clinical Neurophysiology, 2006, 117(12):2584-2596.

Guo Z, Jin Y, Peng H, et al. Clinical study ipsilesional high frequency repetitive transcranial magnetic stimulation add-on therapy improved diffusion parameters of stroke patients with motor dysfunction: a preliminary dti study[J]. 2019.

Klomjai W, Katz R, Lackmy-Vallée A. Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS)[J]. Annals of physical and rehabilitation medicine, 2015, 58(4): 208-213.

Dimyan MA, Cohen LG. Contribution of transcranial mag-netic stimulation to the understanding of functional recov-ery mechanisms after stroke[J]. Neurorehabil Neural Repair, 2010, 24: 125-135.

Klomjai W, Katz R, Lackmy-Vallée A. Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS)[J]. Annals of physical and rehabilitation medicine, 2015, 58(4): 208-213.

Zhang W, Dai L, Liu W, et al. The effect and optimal parameters of repetitive transcranial magnetic stimulation on lower extremity motor function in stroke patient: a systematic review and meta-analysis[J]. Disabil Rehabil. 2023, 22:1-12.

Rastgoo M, Naghdi S, Nakhostin Ansari N, et al. Effects of repetitive transcranial magnetic stimulation on lower extremity spasticity and motor function in stroke patients[J]. Disability and rehabilitation, 2016, 38(19): 1918-1926.

Sharma H, Vishnu V Y, Kumar N, et al. Efficacy of low-frequency repetitive transcranial magnetic stimulation in ischemic stroke: a double-blind randomized controlled trial[J]. Archives of rehabilitation research and clinical translation, 2020, 2(1): 100039.

Lefaucheur J P, Aleman A, Baeken C, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018) [J]. Clinical neurophysiology, 2020, 131(2): 474-528.

Liu Y, Li H, Zhang J, et al. A Meta‐Analysis: Whether Repetitive Transcranial Magnetic Stimulation Improves Dysfunction Caused by Stroke with Lower Limb Spasticity[J]. Evidence‐Based Complementary and Alternative Medicine, 2021, 2021(1): 7219293.

YAN Yulin, YU Lu, SHAO Yang. Effect of low frequency repetitive transcranial magnetic stimulation on lower limb spasticity and balance gait in patients with hemiplegia after stroke[J]. China Medical Herald, 2023, 14(5):81-85.

TAO Feng, WANG Chuanjie, CHEN Benmei, et al. Effects of low frequency repetitive transcranial magnetic stimulation combined with mirror therapy on lower limb motor function and balance in stroke patients with hemiplegia[J]. Chinese Journal of Rehabilitation Medicine, 2022, 37(5):611-615+622.

Ge Lei, Zhao Yuxiao, Qu Shujie, et al. The effect of head needle therapy combined with repeated transcranial magnetic stimulation on the symmetry of motor function, center symmetry and pace of sole pressure in stroke patients[J]. Lishizhen Medicine and Materia Medica Research, 2019, 30(6):1429-1431.

QIN Yin, LIU Yue, GUO Xiaoping, et al. A Comparative Study of High and Low Frequency Repetitive Transcranial Magnetic Stimulation in Treatment of Upper Limb Spasticity after Stroke[J]. Chinese Journal of Stroke, 2018, 13(6):550-555.

Chieffo R, De Prezzo S, Houdayer E, et al. Deep repetitive transcranial magnetic stimulation with H-coil on lower limb motor function in chronic stroke: a pilot study[J]. Archives of physical medicine and rehabilitation, 2014, 95(6): 1141-1147.

Xie Yunjuan, Chen Yi, Tan huixin, et al. Repetitive transcranial magnetic stimulation in the treatment of stroke patients with lower extremity motor function: a systematic review and meta-analysis[J]. Nerve regeneration study, 2022, 16(6): P 1168-1176.

Du J, Yang F, Hu J, et al. Effects of high-and low-frequency repetitive transcranial magnetic stimulation on motor recovery in early stroke patients: evidence from a randomized controlled trial with clinical, neurophysiological and functional imaging assessments [J]. NeuroImage: Clinical, 2019, 21: 101620.vv

TIAN Fei, ZHAO Chenguang, SUN Xiao long, et al. Clinical study on the improvement of walking function by end-effector lower extremity robot combined with high frequency rTMS in recovery stroke patients[J]. Chinese Journal of Rehabilitation Medicine, 2020, 35(8):3.

Xue Hui, Wang Baojun, Liu Guorong, et al. The clinical study of high and low-frequency repetitive transcranial magnetic stimulation on motor function recovery in patients with acute ischemic stroke[C]//Chinese Medical Association; Beijing Medical Association. Chinese Medical Association, Beijing Medical Association, 2013:1030-1030.

ZHOU Jing, SHEN Qinxuan, YANG Yuanbin, et al. Effects of acupuncture combined with high and low frequency repetitive transcranial magnetic stimulation on upper limbs motor function in stroke patients[J]. Chinese Journal of Rehabilitation Medicine, 2023, 38(6):787-792.

Downloads

Published

2025-01-31

How to Cite

Yang, Z., Mei, C., Zhou, M., Mu, R., & Song, S. (2025). Research Progress of Repetitive Transcranial Magnetic Stimulation in Limb Rehabilitation in Patients with Stroke and Hemiplegia. Journal of Contemporary Medical Practice, 7(1), 117–122. https://doi.org/10.53469/jcmp.2025.07(01).23