Effects of Nano-cerium Oxide on the Levels of DHT, TGF-β, and IGF-1 in the Local Skin of AGA Model Mice and Efficacy Observation
DOI:
https://doi.org/10.53469/jcmp.2025.07(01).20Keywords:
Nano-cerium oxide, Androgenetic alopecia (AGA), Dihydrotestosterone (DHT), Transforming growth factor-β (TGF-β), Insulin - like growth factor-1 (IGF-1)Abstract
Objective: Explore the improvement effect of nano-cerium oxide on mice with androgenetic alopecia. Methods: First, the backs of mice were depilated and an androgenetic alopecia model was established by treating them with 5mg/kg testosterone propionate. C57BL/6 mice were randomly divided into 5 groups: the blank group, the model group, the roller microneedle group, the nano-cerium oxide group, and the minoxidil group. Corresponding treatment substances were introduced into the depilated areas respectively. The ratio of terminal hairs to vellus hairs (T/V) in mice was observed through HE histological examination. The contents of dihydrotestosterone (DHT), transforming growth factor-β (TGF-β), and insulin-like growth factor-1(IGF-1) in skin tissues were determined by enzyme-linked immunosorbent assay (ELISA). Results: Compared with the model group, the drug - treated groups could increase the T/V ratio in mice, elevate the protein expression level of IGF-1, and decrease the protein expression level of TGF-β in mice as well as the content of DHT in mouse skin. Conclusions: Nano-cerium oxide has a certain ability to alleviate androgenetic alopecia. It can increase the ratio of terminal hair to vellus hair, providing some theoretical guidance for the development of drugs for the prevention and treatment of androgenetic alopecia.
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