Exploration on the Research Progress of Traditional Chinese Medicine in Treating Uremic Cardiomyopathy based on Cardiomyocyte Protection
DOI:
https://doi.org/10.53469/jcmp.2025.07(01).07Keywords:
Uremic cardiomyopathy, Myocardial cells, Traditional Chinese medicine compound formulaAbstract
Uremic cardiomyopathy is an important complication that affects the quality of life and prognosis of patients with chronic kidney disease. The damage to myocardial cells is a major pathological mechanism of uremic cardiomyopathy. Traditional Chinese medicine (TCM) can promote the elimination of uremic toxins, improve the renal and cardiac function of chronic kidney disease patients, and alleviate renal anemia. At the same time, TCM can regulate relevant signaling pathways and gene expressions through multiple targets, reduce oxidative stress and inflammatory responses in myocardial cells, inhibit apoptosis of myocardial cells, and improve left ventricular hypertrophy and myocardial fibrosis. This ultimately enhances cardiac function and delays the progression of uremic patients and the development of uremic cardiomyopathy. In this paper, the author aims to review recent experimental research advances in TCM for the treatment of uremic cardiomyopathy from the perspective of protecting damaged myocardial cells. The goal is to explore the strategies and methods of TCM in treating uremic cardiomyopathy, providing references and evidence for clinical TCM treatment of this condition.
References
Semple D, Smith K, Bhandari S, Seymour AM. Uremic cardiomyopathy and insulin resistance: a critical role for akt?[J]. J Am Soc Nephrol. 2011 Feb; 22(2):207-215.
DiLullo L, House A, Gorini A, Santoboni A, Russo D, Ronco C. Chronic kidney disease and cardiovascular complications[J]. HeartFailRev. 2015May; 20(3):259-272.
Alhaj E, Alhaj N, Rahman I, Niazi TO, Berkowitz R, Klapholz M. Uremic cardiomyopathy: an underdiagnosed disease[J]. Congest Heart Fail. 2013 Jul-Aug;19(4):E40-E45.
Locatelli F, Marcelli D, Conte F, D'Amico M, Del Vecchio L, Limido A, Malberti F, Spotti D. Cardiovascular disease in chronic renal failure: the challenge continues. Registro Lombardo Dialisi e Trapianto[J]. Nephrol Dial Transplant. 2000;15 Suppl 5:69-80.
Jankowski J, Floege J, Fliser D, Böhm M, Marx N. Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options[J]. Circulation. 2021 Mar 16;143(11):1157-1172.
Liu Shujuan. Retrospective Review of TCM Syndrome on Uremic Myocardiopathy [J]. Shanxi Journal of Traditional Chinese Medicine, 2009, 25(06):49-50+55.
Liu Shujuan, Huang Chunlin. Thinking and Method on the Treatment of Uremic Myocardosis by TCM Combined with Western Medicine [J]. New Journal of Traditional Chinese Medicine, 2005, (03):3-5.
Sun Hui, Yun Ying. Understanding of Etiology and Pathogenesis of Diabetic Nephropathy [J]. Henan Traditional Chinese Medicine, 2008, (09):17-19.
Yang Xuejun, He Liqun. Cardiovascular Complications and Its Chinese Medical Syndromes of Chronic Renal Failure [J]. Shanghai Journal of Traditional Chinese Medicine, 2006, (09):39-42.
Zhang Qian. Clinical observation regarding renal failure enema formula down-regulating uremic toxins to improve renal function and reduce AS lipid accumulation in patients with CKD stages 4-5 [D]. China Academy of Chinese Medical Science, 2023.
Fang Lugui, Wang XiuJuan, Ren Fenglan, et al. Study on the effect of JIAJIANHUANSHUAIFANG on the levels of protein-bound toxin IS and PCS in peritoneal dialysis patients [J]. Journal of Modern Medicine & Health, 2022, 38(06):1016-1019.
Wang Yingyi, Li Jianping, LU Jingbo, et al. Effect and mechanism of Huangkui capsule on reduction of uremic toxin accumulation in an animal model of chronic kidney disease [J]. Acta Pharmaceutica Sinica, 2019, 54(12):2267-2276.
Duan Xuefeng, Jiang Zuanhong, Qin Liqiang, et al. To explore the therapeutic effect of Shenmai injection combined with rhubarb on uremic cardiomyopathy based on NF-κB signal pathway [J]. China Modern Doctor, 2023, 61(04):33-36+40.
Yang Huawei, Pan Hongyi, Wang Jielin, et al. Observation on the clinical efficacy of modified Poge Jiuxin Decoction in the treatment of septic cardiomyopathy [J]. China Modern Drug Application, 2023, 17(24):127-130.
Guo Yining, Liu Jing, Wang Junyan, et al. Study on Effect and Mechanism of Xinyang Tablet (心阳片) -containing Serum Regulating NLRP3-Mediated Pyrocytosis and Protecting Myocardial Cell Inflammation [J]. Chinese Archives of Traditional Chinese Medicine, 2021, 39(08):92-96+271.
Xu Yun. Oxidative stress and cerebral ischaemia-reperfusion injury [J]. Chinese Journal of Stroke, 2008, (03):195-197.
PU Guangji, LI Yuchan, Lou Yingying, et al. Effects of acute exposure to diisodecyl phthalate on kidney in mice and underlying mechanism [J]. Journal of Environmental and Occupational Medicine, 2020, 37(01):51-56.
Liu Guang, Zheng Minlin, San Qin. Protective Effect of Emodin on Myocardial Cell Injury Induced by Indoxyl Sulfate [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2021, 41(05):583-588.
Zheng Minlin, Luo Danlan, Ruan Shiwei. Protectory effects of Yishen Jiangzhuo Granules on kidney in CRF rats and relations between the expression of kidney free radicals, Caspase-3 and Caspase-9 on renal tubular epithelial cell [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2019, 34(08):3460-3464.
Lai Jun. Zhenwu decoction delays ventricular hypertrophy in rats with uremic cardiomyopathy, a preliminary study [D]. Southern Medical University, 2019.
Chen Qi. Protective effects of Zhenwutang on heart injury of uremic cardiomyopathy mice induced by subtotal nephrectomy [D]. Southern Medical University, 2016.
Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007 Jun;35(4):495-516.
Fortuño MA, López N, González A, Díez J. Involvement of cardiomyocyte survival-apoptosis balance in hypertensive cardiac remodeling. Expert Rev Cardiovasc Ther. 2003 Jul;1(2):293-307.
Wang Chen, Liu Mi, Sun Sheng, et al. Panax quinquefolium saponins protect rat myocardium from ischemia/reperfusion injury through attenuating excessive endoplasmic reticulum stress [J]. Chinese Journal of Pathophysiology, 2013, 29(01):20-27.
Tong Mengyao, Jiang Jianqing, Luo Fuli, et al. Study on the Effect of Yishen Jiedu Method on Myocardial Autophagy in Uremic Mice Based on Study on the Effect of Yishen Jiedu Method on Myocardial Autophagy in Uremic Mice Based on [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2023, 40(07):1749-1758.
Zheng Minlin, San Qin, Liu Guang, et al. Effect of therapeutic principle of “cultivating soil to restrict water” on ATP content and mitochondrial Effect of therapeutic principle of “cultivating soil to restrict water” on ATP content and mitochondrial [J]. Journal of Beijing University of Traditional Chinese Medicine, 2021, 44(08):714-721.
Zheng Minlin, San Qin, Liu Guang, et al. Effects of Yishen Jiangzhuo Granules on Bcl-2 and Bax in the heart of uremic cardiomyopathy rats [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2021, 36(09):5561-5564.
Liu Shujuan. Effects of DUNAIQING Granules on cardiomyocyte apoptosis in rats with uremic cardiomyopathy[J]. Shanxi Medical Journal, 2009, 38(04):333-334.
Han Baojuan. Clinical observation on the treatment of uremic cardiomyopathy by lowering toxin and nourishing heart soup [J]. Chinese Journal of Misdiagnostics, 2008, (10):2346-2347.
Wang Xuemin, Yuan Bin. Effect of Angelica sinensis blood replenishing soup combined with adjustable sodium curve dialysis on the effect of uremic cardiomyopathy patients [J]. World Latest Medicine Information, 2018, 18(75):178+183.
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Copyright (c) 2025 Ximeng Yao, Xiaohui Li, Liming Chen, Jie Qu
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