Fur: As a Potential Killer of H. Pylori Iron Death in the Stomach
DOI:
https://doi.org/10.53469/jcmp.2024.06(11).57Keywords:
Helicobacter pylori, Fur, Colonization, Atrophic gastritis, Iron deficiency anemiaAbstract
Helicobacter pylori (H. pylori) is the first pathogenic bacterium found in the stomach causing maltiple diseases related to the digestive system. Studies on H. pylori are important for understanding the overall population of the bacteria that reside in the digestive tract. Ferric uptake regulation protein (Fur) excellently regulates H. pylori and is closely related to the structure, pathogenesis, escape, and transfer mechanisms of the bacterium. Focusing on the correlation between Fur and H. pylori, the involvement of Fur in different aspects of H. pylori in host organisms was systematically investigated. Our research revealed that Fur is involved in H. pylori colonization in the stomach, altering the gastric environment to create more suitable survival conditions, inducing pathogeny of the host, and curing H. pylori-related diseases. Fur has an important role in the colonization of H. pylori, and Fur appears to be influenced by a variety of trace elements, including iron, and altering iron homeostasis appears to be an effective means of inhibiting Fur. In addition to the factor that H. pylori and the host belong to two species, the strong acidic environment in the stomach also acts as a catalyst for chemical reactions that create favorable factors for the altered iron homeostasis environment. The performance of Fur makes it impossible to ignore the presence of Fur in the study of H. pylori, and the induction of iron death by creating a homeostatic environment in the stomach that inhibits Fur may become a new research direction and play an important role in the treatment of H. pylori. Moreover, Fur has a significant impact on the progression of various digestive diseases.
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