Research Progress on Insulin Resistance Mechanism of Intermittent Hypoxia in Skeletal Muscle
DOI:
https://doi.org/10.53469/jcmp.2024.06(11).48Keywords:
Sleep apnea syndrome, Intermittent hypoxia, Insulin resistance, Type 2 diabetes, Skeletal muscleAbstract
Sleep apnea syndrome (SAS) is a common clinical disease, which is characterized by repeated episodes of apnea or hypoxia, leading to intermittent hypoxia (IH) and sleep awakening. Many clinical studies show that diabetes is the main complication of SAS. Previous studies have shown that nocturnal IH is the main complication of SAS. Previous studies have shown that nocturnal IH is the main cause of hyperglycemia in SAS patients. Therefore, IH is closely related to the pathogenesis of type 2 diabetes, but the pathophysiology and molecular structure of IH are not well understood. Therefore, IH is closely related to the pathogenesis of type 2 diabetes, but the pathophysiology and molecular mechanism of abnormal glucose metabolism induced by IH have not been fully revealed. In healthy people, skeletal muscle accounts for 70%-80% of IH. In healthy people, skeletal muscle accounts for 70%-80% of glucose intake stimulated by insulin, which plays a key role in regulating glucose homeostasis. IR in skeletal muscle has long been considered as a characteristic of type 2 diabetes. IR in skeletal muscle has long been considered as a characteristic of type 2 diabetes mellitus and plays a major role in the pathogenesis of the disease. This review provides a new idea for the role of IH in the disease. This review provides a new idea for the role of IH in the pathological process of diabetes by expounding the regulation of IH on skeletal muscle, and brings a new dawn for the treatment of SAS complicated with diabetes.
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