Mechanisms and Progress of TIF1 Proteins in Digestive Tract Tumors
DOI:
https://doi.org/10.53469/jcmp.2024.06(11).44Keywords:
Digestive system cancers, TIF1 protein, TRIM proteinAbstract
Digestive system cancers, including esophageal cancer, gastric cancer, and colorectal cancer, are common types of malignant tumors. Due to their relatively obscure early symptoms, they are often overlooked, leading to worsened conditions and poor prognosis. With improvements in medical technology, the prognosis for patients with digestive tract tumors has improved, but recurrence and metastasis rates remain high. The Transcription Intermediary Factor 1 (TIF1) family, consisting of TRIM24, TRIM28, TRIM33, and TRIM66, is a subfamily of the E3 ubiquitin ligase TRIM family involved in various biological processes such as cell signaling, immunity, and viral infection. A growing number of studies have shown that the TIF1 protein family regulates multiple biological activities and signaling cascades in digestive tract tumors, including immune engagement, metabolic reprogramming, and histone modifications. This review aims to explore the mechanisms and progress of TIF1 protein family members in the development of digestive tract tumors.
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Copyright (c) 2024 Changming Zhang, Ruoyu Wang, Ming Dong
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