Progress of Microvascular Invasion in Hepatic Alveolar Echinococcosis

Authors

  • Mengzhao Xu Qinghai University, Xining 810016, Qinghai, China
  • Linxun Liu Qinghai Provincial People's Hospital, Xining 810007, Qinghai, China
  • Runwu Cao Qinghai University, Xining 810016, Qinghai, China
  • Fei Ke Qinghai University, Xining 810016, Qinghai, China
  • Qihua Feng Qinghai University, Xining 810016, Qinghai, China

DOI:

https://doi.org/10.53469/jcmp.2024.06(11).43

Keywords:

Hepatic alveolar echinococcosis, Microvascular invasion, Vascular endothelial growth factor

Abstract

Alveolar echinococcosis (AE) is a kind of zoonotic parasitic disease caused by multi-atrial echinococcus tapeworm infection in humans or animals. Multi-atrial echinococcus larvae are often parasitized in the liver, and the treatment is based on surgical resection, supplemented by drug treatment. Hepatic alveolar echinococcosis(HAE) larvae foci are chronic infiltrative growth, no special symptoms in the early stage, most of the patients are already in the late stage at the onset of the disease, mostly accompanied by tissue invasion around the foci and metastasis to distant organs, at this time, most of the patients do not have the indications for radical surgery, recent studies have shown that HAE larvae foci around the microvascular infiltration may be an important basis for its infiltration and proliferation of metastasis. In this paper, we synthesize the latest research progresses at home and abroad, and give an in-depth description of the pathological mechanism, imaging and serological characteristics of microvascular invasion in HAE is foci, aiming to promote the development of diagnosis and treatment of microvascular invasion in HAE.

References

Jensenius M, Mørch K, Yaqub S, Halvorsen DS, Reims HM, Björk IG, Røsok BI, Oltmanns G, Helbak K, Øines Ø, Lier T. Alveolar echinococcosis [J]. Tidsskr Nor Laegeforen, 2024, 144(10).

Zhao SY, Zhu HH, Wang XQ, A JD, Lu XL, Tian QS, Pan HS, Liu LX, Wu SL, Han XM, Guo YM. Present situation and progress of comprehensive treatments for hepatic alveolar echinococcosis [J]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, 2019, 31(6): 676-678.

Deplazes P, Rinaldi L, Alvarez Rojas CA, Torgerson PR, Harandi MF, Romig T, Antolova D, Schurer JM, Lahmar S, Cringoli G, Magambo J, Thompson RC, Jenkins EJ. Global Distribution of Alveolar and Cystic Echinococcosis [J]. Adv Parasitol, 2017, 95:315-493.

Mihmanli M, Idiz UO, Kaya C, Demir U, Bostanci O, Omeroglu S, Bozkurt E. Current status of diagnosis and treatment of hepatic echinococcosis [J]. World J Hepatol. 2016, 8(28):1169-1181.

Hemphill A, Stadelmann B, Rufener R, Spiliotis M, Boubaker G, Müller J, Müller N, Gorgas D, Gottstein B. Treatment of echinococcosis: albendazole and mebendazole--what else? [J]. Parasite, 2014, 21:70.

Xu X, Qian X, Gao C, Pang Y, Zhou H, Zhu L, Wang Z, Pang M, Wu D, Yu W, Kong F, Shi D, Guo Y, Su X, Hu W, Yan J, Feng X, Fan H. Advances in the pharmacological treatment of hepatic alveolar echinococcosis: From laboratory to clinic [J]. Front Microbiol, 2022, 13:953846.

Wang Z, Jiang T, Aji T, Wen H. Massive sympathetic nerve infiltration in advanced hepatic alveolar echinococcosis: a case report and review of the literature [J]. BMC Infect Dis, 2022, 22(1):489.

Svagzdys S, Lesauskaite V, Pavalkis D, Nedzelskiene I, Pranys D, Tamelis A. Microvessel density as new prognostic marker after radiotherapy in rectal cancer [J]. BMC Cancer, 2009, 9:95.

YIN Qiuping, ZHANG Yuying, MA Qinfeng, et al. A study on the correlation between ARFI examination of the marginal zone and pathologic histology of different types of hepatic vesicular encapsulated lesions [J]. Journal of Medical Imaging, 2023, 33(01):52-55.

Liu Y, Hou B, Chen R, Jin H, Zhong X, Ye W, Liang C. Biliary collateral veins and associated biliary abnormalities of portal hypertensive biliopathy in patients with cavernous transformation of portal vein [J]. Clin Imaging, 2015, 39(5):841-844.

CHEN Qian, ZHANG Huai, SU Qiangming, et al. Experimental study of recombinant human vascular endothelial inhibitor inhibiting perivascular angiogenesis in gerbil liver vesicular echinococcus [J]. Chinese Journal of Pathobiology, 2017, 12(04): 321-324+327.

Song T. Gray-scale ultrasonography on the infiltration and proliferation zone of hepatic vesicular echinococcosis [D]. Xinjiang Medical University, 2012.

WANG Ying, Lv Yongquan. Application of color Doppler energy mapping in the differential diagnosis of hepatic vesicular echinococcosis and hepatocellular carcinoma [J]. Chinese Journal of Ultrasonography, 2002, (01):25-27.

Chen L. Consistency study of ultrasonography in evaluating the activity of infiltrating and proliferating zones of rat liver follicular schistosomiasis [D]. Xinjiang Medical University, China, 2019.

YAN Youxia, TIAN Qingshan, WANG Shunjuan, et al. Application value of positron emission-computed tomography in resectability and resection range of hepatic vesicular echinococcosis [J]. Chinese Journal of Liver Diseases (Electronic Edition), 2020, 12(04):78-82.

LIU Li, DING Shirong, PU Peng, et al. Diagnostic value of multislice spiral CT for hepatic vesicular echinococcosis involving the vascular system [J]. Chinese Journal of CT and MRI, 2016, 14(10):74-76.

LIU Wenya, LOU Jianru, XING Yan, et al. Multislice spiral CT imaging features of vesicular echinococcosis of the liver [J]. Chinese Journal of Radiology, 2005, (08):860-863.

JIANG Yi, WANG Jing, XIAO Hu, et al. Dual source CT energy imaging to assess the blood supply distribution of hepatic blastomycosis: quantitative iodine concentration and histopathologic correlation study [J]. Journal of Xinjiang Medical University, 2015, 38(10):1207-1212.

ZHANG Hongqian, BAO Haihua, LI Weixia, et al. Preoperative evaluation of hepatic blastomycosis by magnetic resonance multimodal imaging [J]. Journal of Plateau Medicine, 2020, 30(03):10-15.

Ren Bo. Contrasting analysis of imaging features and histopathology of the marginal zone of hepatic vesicular bulbous larvae based on MR diffusion imaging [D]. Xinjiang Medical University, 2011.

Azizi A, Blagosklonov O, Lounis A, Berthet L, Vuitton DA, Bresson-Hadni S, Delabrousse E. Alveolar echinococcosis: correlation between hepatic MRI findings and FDG-PET/CT metabolic activity [J]. Abdom Imaging, 2015, 40(1):56-63.

Nikendei C, Greinacher A, Berkunova A, Junghanss T, Stojkovic M. Psychological burden and resilience factors in patients with Alveolar Echinococcosis - A cross-sectional study [J]. PLoS Negl Trop Dis, 2019, 13(1):e0007082.

Melincovici CS, Boşca AB, Şuşman S, Mărginean M, Mihu C, Istrate M, Moldovan IM, Roman AL, Mihu CM. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis [J]. Rom J Morphol Embryol, 2018, 59(2):455-467.

JIANG Huijiao, GUI Xianwei, GUO Lijiao, et al. Expression and role of VEGFA/VEGFR2 in angiogenesis of hepatic multilocular echinococcus granulosus tissue in mice [J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(06): 673-681.

ZHANG Shijie, WU Hexing, LI Qi, et al. Expression and significance of microvessel density and vascular endothelial growth factor in gerbil hepatic blastococcal larvae tissues [J]. Chinese Basic and Clinical Journal of General Surgery, 2015, 22(02):134-138.

Fina L, Molgaard HV, Robertson D, Bradley NJ, Monaghan P, Delia D, Sutherland DR, Baker MA, Greaves MF. Expression of the CD34 gene in vascular endothelial cells [J]. Blood, 1990, 75(12):2417-26. PMID: 1693532.

Li-Tong,Zhang Shi-Jie. Role of neovascularization in the infiltrative growth of hepatic vesicular coccidia [J]. Chinese Journal of Animal and Human Diseases. 2014, 30(10):1071-1074.

Guidelines for treatment of cystic and alveolar echinococcosis in humans. WHO Informal Working Group on Echinococcosis [J]. Bull World Health Organ. 1996, 74(3):231-42. PMID: 8789923; PMCID: PMC2486920.

XU Shuo, DANG Zhisheng, ZHANG Haobing, et al. Research progress of drug therapy for echinococcosis [J]. Chinese Journal of Parasitology and Parasitic Diseases, 2018, 36(03):297-302.

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Published

2024-11-28

How to Cite

Xu, M., Liu, L., Cao, R., Ke, F., & Feng, Q. (2024). Progress of Microvascular Invasion in Hepatic Alveolar Echinococcosis. Journal of Contemporary Medical Practice, 6(11), 220–223. https://doi.org/10.53469/jcmp.2024.06(11).43