Research Progress on the Mechanism of Acupuncture in the Treatment of PTSD

Authors

  • Xuanyu Zhang School of Acupuncture, Moxibustion and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Jing Han School of Education, Shaanxi Normal University, Xi'an 710000, Shaanxi, China
  • Li Lin School of Acupuncture, Moxibustion and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Yusu Shi School of Acupuncture, Moxibustion and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Yongfeng Li School of Acupuncture, Moxibustion and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China

DOI:

https://doi.org/10.53469/jcmp.2024.06(11).28

Keywords:

Acupuncture, Post-traumatic stress disorder, Mechanism of action, Application progress

Abstract

At present, there is a lot of room for increase in acupuncture treatment of Post-traumatic Stress Disorder, both in terms of research and the number of articles published. This article reviews the clinical and mechanism of acupuncture treatment of PTSD at home and abroad in recent years. Clinical studies have shown that acupuncture can effectively alleviate PTSD-related symptoms and is an effective means of treating PTSD. Experimental studies have shown that the mechanism of acupuncture therapy for PTSD may involve regulating neural loops, neurotransmitter and receptor expression, signaling pathways, apoptosis, immune cytokin and endogenous cannabinoids. This can provide a reference basis for the clinical application of acupuncture treatment of PTSD and provide new ideas for future in-depth clinical research.

References

Wang Qingsong, Tan Qingrong. Guidelines for the prevention and treatment of post-traumatic stress disorder [M]. Beijing: People's Health Publishing House, 2015: 15-16.

Song Kai, Zhang Hong, Xiong Fanjie, et al. Law and Actuality of Acupuncture for Post-traumatic Stress Disorder [J]. Journal of Chengdu University of Traditional Chinese Medicine, 2021, 44(3): 93-97.

Ren Fangfang, Zhang Lei, Li Dun, et al. Acupuncture and moxibustion treatment of post-traumatic stress disorder[J]. Shanghai Journal of Acupuncture and Moxibustion, 2021, 40(8): 1030-1034.

LI Xiao-yan, SUN Yi-ping, LU Jun, et al. Progress of researches on acupuncture and moxibustion for treating post-traumatic stress disorder in the past five years[J]. Acupuncture Research, 2021, 46(5): 439-444.

Wang Yanzhen, Zhang Hong, Peng Yulin, etc. Discuss the treatment of post-traumatic stress disorder with acupuncture from acupoint selection[J]. Henan Traditional Chinese Medicine, 2013, 33(8): 1321-1323.

Yin Chong, Zhang Hong, Chen Weiwei, etc. Preliminary exploration of post-traumatic stress disorder and its acupuncture treatment[J]. Journal of Sichuan of Traditional Chinese Medicine, 2009, 27(8): 123-125.

Zhou Zhongying. Traditional Chinese medicine and internal medicine [M]. Beijing: China Traditional Chinese Medicine Press, 2003: 392-400.

Zhang Yanfeng, Han Yadi, Zhao Zhongting, et al. Exploration of acupoints selection law for post-traumatic stress disorder treated with acupuncture and moxibustion[J]. Chinese Acupuncture & Moxibustion, 2016, 36(11): 1229-1232.

Zhang Hong, Yuan Caifeng, Ran Lianhui, et al. RCT research of different acupuncture therapies in treating Posttraumatic stress disorder after Wenchuan ‘5.12’ earthquake [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2010, 25(9): 1505-1510.

ZHANG Jing, LIU Zhengkui, MA Zhujiang, et al. Symptoms of post-traumatic stress disorder and its related factors among parents who lost their single child[J]. Chinese Mental Health Journal, 2019, 33(1): 21-26.

Zhao Zhongting, Zhao Yaodong, Zheng Qianhua, etc. Progress in modern clinical research on acupuncture intervention PTSD [J]. Lishizhen Medicine and Materia Medica Research, 2015, 26(6): 1444-1446.

Ran Qiang, Xiao Yuqi, Li Ping, et al. Clinical Observation of Electroacupuncture Combined with Moxibustion on PTSD [J]. Journal of Emergency in Traditional Chinese Medicine, 2018, 27(2): 246-248.

Wang Zhongheng, Zhou Ping, Tan Qingrong. Effect of electric acupuncture combined with paroxetine in treatment of patients with post-traumatic stress disorder[J]. Journal of Psychiatry, 2015, 28(5): 326-328.

Zhou Ping, Zhang Yao, Tan Qingrong. Effects of electric acupuncture combined with sertraline in the treatment of post-traumatic stress disorder[J]. Sichuan Mental Health, 2015, 28(6): 504-507.

Kim YD, Heo I, Shin BC, et al. Acupuncture for posttraumatic stress disorder: a systematic review of randomized controlled trials and prospective clinical trials[J]. Evid Based Complement Alternat Med, 2013, 2013:615857.

Han Yadi, Zhang Yanfeng, Yan Xingke. Meta-analysis of acupuncture treatment of post-t traumatic stress disorder [J]. Journal of Gansu College of Traditional Chinese Medicine, 2017, 34(1): 69-74.

ZHAO Guijun, LI Xiaoling, LI Mingyan, et al. Clinical Observation of Female Post-Traumatic Stress Disorder Treated by Electroacupuncture by Tonifying Kidney and Dredging Du Meridian Method[J]. Liaoning Journal of Traditional Chinese Medicine, 2020, 47(2): 175-177.

LI Shuo-shuo, LIU Qian-dong, YUAN Zeng-qiang. Progress in mechanism and treatment of post-traumatic stress disorder[J]. Chinese Journal of Pharmacology and Toxicology, 2017, 31(12): 1185-1193.

Zheng Chengqiang, Tan Lingxiao, Zhou Tianxiu, et al. Effects of electroacupuncture on resting-state encephalic functional connectivity network in patients with PTSD[J]. Chinese Acupuncture & Moxibustion, 2015, 35(5): 469-473.

Zheng Chengqiang, Zhang Hong. Study on the effect of acupuncture "adjusting the mind to wake up the brain" method on the connection network of resting amygdala function in PTSD patients[J]. Lishizhen Medicine and Materia Medica Research. 2016, 27(6): 1524-1526.

LI Yue - feng, SI Xin - lei, CAO Rui, et al. Effect of Sinisan on hippocampal neurons discharge amplitude in rats with post-traumatic stress disorder and sleep disorder[J]. The Chinese Journal of Clinical Pharmacology, 2018, 34(10): 1203-1205.

CAO Rui, NIU Jiang-tao, SI Xin-lei, et al. Effects of Sinisan on brain waves in rats with post traumatic stress and sleep disorder[J]. The Chinese Journal of Clinical Pharmacology, 2018, 34(15): 1886-1889.

YU Chao, TIAN Lei, ZHANG Shuhang, et al. Effect of Acupuncture and Moxibustion on the Spatial and Temporal Patterns of Abnormal Neuronal Information in Hippocampus of Rats with Sleep Disorder Induced by Post-Traumatic Stress Disorder and the Ultrastructure of Damaged Neurons[J]. Journal of Sichuan of Traditional Chinese Medicine, 2019, 37(6): 29-32.

NEDELCOVYCH MT, GOULDR W, ZHAN XY, et al. Arodent model of traumatics tress inducles lasting sleep and quantitative electroencephalographic disturbances [J]. ACS Chem Neurosci, 2015, 6(3): 485-493.

Li Fenglei, Zhou Cuihong, Peng noon, et al. The Influence of Electroacupuncture (EA) Preconditioning on Anxiety-like Behavior and the Expression of Sirt1/MAO-A in the Hippocampus of PTSD Rats[J]. Progress in Modern Biomedicine, 2017, 17(35): 6839-6843.

LI LP, DUSTRUDE E T, HAULCOMB MM, et al. PSD95 and nNOS intercation as a novel moleculartar get to modulate condition edfear: relevance to PTSD[J]. Transl Psychiatry, 2018, 8(1): 155.

HONG C, CAO J, WU CF, et al. The Chinese herbal for mulaFree and Easy Wander ameliorate soxidative stress through KEAP1-NRF2/HO-1 pathway[J]. SciRep, 2017, 7(1): 11551.

Sui Zhuxin, Liu Hao, Wang Haitao, et al. Alteration of Apoptosis and Akt/mTOR Signal Pathway in Hippocampal Neurons of Rat with Post-traumatic Stress Disorder [J]. Journal of Sichuan University (Medical Sciences), 2014, 45(2): 221-224.

XIAO B, HAN F, SHI Y. Administration of moclobemide facilitates fear extinction and attenuates anxiety like behaviors by regulating synaptic associated post traumatic stress disorder[J]. Synapse, 2020, 74(6): e22146.

Wang Haitao, Liu Hao, Xu Aijun, et al. Neuronal apoptosis and expressions of Caspase-9 in hippocampus and amygdala of PTSD rats and their significances[J]. Journal of Jilin University: Medicine Edition, 2013, 39(3): 427-431.

Liu Qianru, Wang Li, Qi Ming, et al. Effects of electro-acupuncture on learning and memory and Bcl-2/Bax expression in hippocampal CA1 region of PTSD-like rats[J]. Acta Universitatis Medicinalis Anhui, 2020, 55(3): 340-344.

LIU L M, LIU H, HOU Y C, et al. Temporal effect of electracupuncture on anxiety like behaviors and c-Fos expression in the anterior cingulate cortex in a rat model of post-traumatic stress disorder[J]. Neurosci Lett, 2019, 711:134432.

ZHU Xiuling, LU Yaping. Electroacupuncture inhibits increase of TH and decrease of BDNF in the amygdala of PTSD rats[J]. Journal of Wannan Medical College, 2019, 38(2): 115-119.

JENNICHESI, TERNESS, ALBAYRAM O, et al. Anxiety, stress, and fer response in mice with reduced endocannabinoid levels[J]. BiolPsychiatry, 2016, 79(10): 858-868.

WANG W W, WANG L, XU H, et al. Characteristics of proandanti in flammatioty cytokine salteration in PTSD patient sexpased to a deadly earth quake [J]. LAffect Disord, 2019, 248: 52-58.

Downloads

Published

2024-11-28

How to Cite

Zhang, X., Han, J., Lin, L., Shi, Y., & Li, Y. (2024). Research Progress on the Mechanism of Acupuncture in the Treatment of PTSD. Journal of Contemporary Medical Practice, 6(11), 138–143. https://doi.org/10.53469/jcmp.2024.06(11).28