Research Progress of Hawthorn in the Treatment of Non-alcoholic Fatty Liver Disease
DOI:
https://doi.org/10.53469/jcmp.2024.06(10).20Keywords:
Non-alcoholic fatty liver disease, Hawthorn, Research progressAbstract
Non-alcoholic fatty liver disease refers to a metabolic disease of the liver caused by long-term heavy drinking and other clear liver damage factors, with triglyceride-dominated lipids accumulating in liver cells for pathological changes. In traditional Chinese medicine, it is often classified as "accumulation", "liver puffiness", "liver", "fat qi" and other categories. Hawthorn is the most commonly used Chinese medicine for the treatment of non-alcoholic fatty liver disease. This review is to summarize the latest research progress of hawthorn effective components in the treatment of this disease, and summarize and explain the understanding and application of traditional Chinese medicine, pharmacological effects and mechanism progress, in order to provide more basis for the clinical treatment of NAFLD with traditional Chinese medicine.
References
Estes C, Anstee Q M, Arias-Loste M T, et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030[J]. J Hepatol, 2018, 69(4): 896-904.
YANG Lexuan, HUANG Laping. Discussion on Treating Non-Alcoholic Fatty Liver Disease Based on Theory of Ministerial Fire[J]. New Chinese Medicine, 2024,56(14):184-190.
Peng Danyang, Wang Lin, Zhu Dezeng. Clinical study of hawthorn pure extract tablet in treatment of metabolic syndrome[J]. Journal of Changchun University of Chinese Medicine, 2011,27(05):723-724.
Li Guangshan, Zhang Hong. Effect of hawthorn and wolfberry tea on blood lipids in patients with type 2 diabetes mellitus and hyperlipidemia[J]. Jilin Journal of Chinese Medicine, 2008(07):495.
Zheng Shuwei, Cao Anmin, Huang Junmin, et al. Ultrasonic evaluation of Shanzhajiangzhi prescription combined with ear pressure in the treatment of nonalcoholic fatty liver[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2015, 24(31):3494-3496.
TAO Zhenghui. Pharmacologic Analysis of Long-term High Dose Single Herb Hawthorn on Blood Lipids in Patients with Nonalcoholic Fatty Liver Disease Caused by High Fat Diet[J]. GUANGMING JOURNAL OF CHINESE MEDICINE, 2021,36(12):1991-1993.
NIE Chun-xia, HE Pan, HAO Yan-yan, LIU Cong, NI Yan, HAO Xu-liang. Effects of different processed products of Crataegi Fructus on hyperlipidemia rat model by ~1H-NMR metabolomics[J]. Chinese Traditional and Herbal Drugs, 2019,50(10):2362-2370.
Wu Yuan. Based on data mining and network pharmacology, the rule and mechanism of Chinese medicine in improving insulin resistance in non-alcoholic fatty liver disease were studied[D]. Heilongjiang University of Chinese Medicine, 2023.
Marcolin E, San-Miguel B, Vallejo D, et al. Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis[J]. J Nutr, 2012, 142(10):1821-1828.
Panchal S K, Poudyal H, Brown L. Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats[J]. J Nutr, 2012,142(6):1026-1032.
Zhang Jie, Chen Jiebin. Effects of quercetin on the expression of ATP-bindingcassette transporter A1 in nonalcoholic fatty liver cells[J]. Journal of Jiangsu University: Medicine Edition, 2009,19(05):398-400.
Liu Z K, Xiao H B, Fang J. Anti-inflammatory properties of kaempferol via its inhibition of aldosterone signaling and aldosterone-induced gene expression[J]. Can J Physiol Pharmacol, 2014,92(2):117-123.
Huang Y B, Lin M W, Chao Y, et al. Anti-oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol[J]. Int J Urol, 2014, 21(1):94-98.
Hubbard G P, Wolffram S, de Vos R, et al. Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study[J]. Br J Nutr, 2006,96(3):482-488.
Zhang Y, Gu M, Cai W, et al. Dietary component isorhamnetin is a PPARgamma antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency[J]. Sci Rep, 2016,6:19288.
Yoshida Y, Niki E. Antioxidant effects of phytosterol and its components[J]. J Nutr Sci Vitaminol (Tokyo), 2003,49(4):277-280.
Huang Jianchun, Qing Lijuan, Xuan Feifei, et al. Study on Antioxidant Activity of Stigmaserol from Yulangsan in vitro[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2014,20(05):154-156.
Saliba S W, Marcotegui A R, Fortwangler E, et al. Correction to: AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity[J]. J Neuroinflammation, 2018, 15(1):34.
Ribeiro D, Freitas M, Tome S M, et al. Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine / chemokine production in human whole blood[J]. Inflammation, 2015,38(2):858-870.
Yao L, Liu F, Sun L, et al. Upregulation of PPARgamma in tissue with gastric carcinoma[J]. Hybridoma (Larchmt), 2010,29(4):341-343.
Ohkubo Y, Sekido T, Nishio S I, et al. Loss of mu-crystallin causes PPARgamma activation and obesity in high-fat diet-fed mice[J]. Biochem Biophys Res Commun, 2019,508(3):914-920.
Moran-Salvador E, Lopez-Parra M, Garcia-Alonso V, et al. Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts[J]. FASEB J, 2011,25(8):2538-2550.
Nan Y M, Fu N, Wu W J, et al. Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice[J]. Scand J Gastroenterol, 2009,44(3):358-365.
Elshorbagy A K, Valdivia-Garcia M, Mattocks D A, et al. Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase[J]. J Lipid Res, 2011, 52(1):104-112.
Janaszak-Jasiecka A, Siekierzycka A, Bartoszewska S, et al. eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells[J]. Angiogenesis, 2018,21(4):711-724.
Wu Xinyi. To study the prevention and treatment effect of panax notoginseng saponins on nonalcoholic fatty liver based on the changes of NO and iNOS[D]. Yunnan University of Traditional Chinese Medicine, 2018.
Kuang Rong, Chen Nan, Kang Hua, et al. Mechanisms of Total Flavones of Crataegus Leaves on Experimental Atherosclerosis in Rabbits[J]. Chinese Journal of Modern Applied Pharmacy, 2013,30(04):372-375.
Chang lulin. Effect of Total Flavone of Hawthorn on Ethanol Induced Alcoholic Liver Disease in Mice[J]. Chinese Medicine Modern Distance Education of China, 2014,12(07):152-153.
Calvaruso V, Maimone S, Gatt A, et al. Coagulation and fibrosis in chronic liver disease[J]. Gut, 2008, 57(12): 1722-1727.
SUN Yuanpei, GUO Xiaoxia. Clinical effect of probiotics in treatment of liver cirrhosis: a Meta-analysis[J]. Journal of Clinical Hepatology, 2018, 34(01):73-79.
Pradere J P, Hernandez C, Koppe C, et al. Negative regulation of NF-kappaB p65 activity by serine 536 phosphorylation[J]. Sci Signal, 2016,9(442):ra85.
Garcia-Compean D, Gonzalez-Gonzalez J A, Lavalle-Gonzalez F J, et al. Current Concepts in Diabetes Mellitus and Chronic Liver Disease: Clinical Outcomes, Hepatitis C Virus Association, and Therapy [J]. Dig Dis Sci, 2016,61(2):371-380.
Yu I C, Lin H Y, Sparks J D, et al. Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome[J]. Diabetes, 2014,63(10):3180-3188.
Chin K Y, Ima-Nirwana S. The Effects of Testosterone Deficiency and Its Replacement on Inflammatory Markers in Rats: A Pilot Study[J]. Int J Endocrinol Metab, 2017,15(1):e43053.
Pipatpiboon N, Pintana H, Pratchayasakul W, et al. DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption[J]. Eur J Neurosci, 2013, 37(5):839-849.
Lagathu C, Bastard J P, Auclair M, et al. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone[J]. Biochem Biophys Res Commun, 2003,311(2):372-379.
Zhou Ying, Zhang Lijuan. Insulin resistance and inflammatory factors and their related signaling pathways[J]. Chinese Journal of Cardiovascular Rehabilitation Medicine, 2010,19(01):107-109.
Yuan Y, Wang X, Lu X, et al. Effect of Coptidis Rhizoma extracts in a water-based solution on insulin resistance in 3T3-L1 adipocytes[J]. Biomed Res, 2014, 35(5):321-327.
Shih C C, Lin C H, Lin Y J, et al. Validation of the Antidiabetic and Hypolipidemic Effects of Hawthorn by Assessment of Gluconeogenesis and Lipogenesis Related Genes and AMP-Activated Protein Kinase Phosphorylation[J]. Evid Based Complement Alternat Med, 2013, 2013:597067.
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