Research Progress on the Intervention of Traditional Chinese Medicine in Signal Pathways Related to Acute Cerebral Infarction
DOI:
https://doi.org/10.53469/jcmp.2024.06(09).28Keywords:
Traditional Chinese Medicine, Acute Cerebral Infarction, Signal Pathways, Research ProgressAbstract
Acute cerebral infarction is a disease with high incidence, mortality, and disability rates. Its etiology is complex, and the exact pathogenesis is not yet fully understood. Current studies often involve inflammatory responses, apoptosis, oxidative stress, atherosclerosis, excitotoxicity, and free radical chain reactions. Signal pathways play a crucial role in the occurrence and development of this condition. Traditional Chinese medicine can improve the condition of patients with acute cerebral infarction by intervening in multiple signal pathways. This paper systematically reviews recent literature, identifying 11 key signal pathways, including NLRP3, TLR4/NF-κB, Nrf2/ARE, CD40/CD40L, JAK/STAT, PI3K/AKT, JNK/p38 MAPK, Wnt, Notch, RhoA/ROCK, and ERK1/2. The aim is to provide some reference for the research on traditional Chinese medicine treatments for acute cerebral infarction.
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