Research Progress on the Correlation between Gut Microorganisms and Gastrointestinal Diseases

Authors

  • Yuanyuan Li College of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Xiaokang Wu College of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China; Clinical laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China

DOI:

https://doi.org/10.53469/jcmp.2024.06(09).27

Keywords:

Gut microorganisms, Digestive System Neoplasms, Gastrointestinal diseases

Abstract

The intestinal microbiota refers to the complex community of microorganisms present in the human digestive tract. With the development of high-throughput sequencing technologies such as 16SrRNA gene sequencing and metagenomic sequencing, the intestinal microbiota has been shown to be closely related to gastric cancer and colorectal cancer. At the same time, a series of studies have been conducted to explore the intestinal microbiota as a new type of non-invasive biological marker. This article summarizes the research on the intestinal microbiota of gastric cancer and colorectal cancer, and explains the changes in the intestinal microbiota when the disease occurs, so as to provide new ideas for finding potential molecular targets for the prevention, treatment, and intervention of tumors.

References

Yong F, Oluf P. Gut microbiota in human metabolic health and disease[J]. Nature reviews. Microbiology, 2020.

Wenly R, A M E, K J S, et al. Healthy Human Gastrointestinal Microbiome: Composition and Function After a Decade of Exploration [J]. Digestive diseases and sciences, 2020, 65(3):695-705.

L. R S, D. K M, E. H F, et al. Cancer statistics, 2022 [J]. CA: A Cancer Journal for Clinicians, 2022, 72(1): 7-33.

Smyth C E, Nilsson M, Grabsch I H, et al. Gastric cancer [J]. The Lancet, 2020, 396(10251):635-648.

Eileen M, Melina A, Constanza M C, et al. The current and future incidence and mortality of gastric cancer in 185 countries, 2020–40: A population-based modelling study[J]. eClinical Medicine, 2022, 47101404-101404.

Hiroshi O, Naoko S. Stomach microbiota, Helicobacter pylori, and group 2 innate lymphoid cells[J]. Experimental & molecular medicine, 2020, 52(9): 1377-1382.

Majid A. Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer[J]. Journal of gastrointestinal cancer, 2020, 52(1):1-8.

Yihan Y, Xu S, Chuan X. An Overview of Autophagy in Helicobacter pylori Infection and Related Gastric Cancer [J]. Frontiers in Cellular and Infection Microbiology, 2022, 12847716-847716.

Wei Z, Jing M, Lingling L, et al. The Effects of Helicobacter pylori Infection on Microbiota Associated With Gastric Mucosa and Immune Factors in Children [J]. Frontiers in Immunology, 2021, 12625586-625586.

Xinmei Z, Chao L, Weijun C, et al. Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages[J]. Frontiers in Cellular and Infection Microbiology, 2021, 11559148-559148.

Deng Y, Ding X, Song Q, et al. Alterations in mucosa - associated microbiota in the stomach of patients with gastric cancer[J]. Cellular Oncology, 2021, 44(3):1-14.

QingHua S, Jing Z, YanYan S, et al. Microbiome changes in the gastric mucosa and gastric juice in different histological stages of Helicobacter pylori-negative gastric cancers [J]. World journal of gastroenterology, 2022, 28(3):365-380.

Xuan P, Siqi Y, Jing H, et al. Alterations in bacterial community dynamics from noncancerous to Gastric cancer [J]. Frontiers in Microbiology, 2023, 141138928-1138928.

Linli S, Qilin F, Bin Z, et al. The composition and functional profile of the microbial communities in human gastric cancer tissues and adjacent normal tissues [J]. Acta biochimica et biophysica Sinica, 2021, 54(1):1-8.

Zhen-Feng W, Kun Z, Guan-Nan W, et al. A Comparison of Tumor-Associated and Non-Tumor- Associated Gastric Microbiota in Gastric Cancer Patients. [J]. Digestive diseases and sciences, 2020, 66(prepublish):1-10.

Yan L, Yichen H, Xiang Z, et al. Meta-analysis reveals Helicobacter pylori mutual exclusivity and reproducible gastric microbiome alterations during gastric carcinoma progression. [J]. Gut microbes, 2023, 15(1): 2197835-2197835.

Ka-Shing C, K W L. Risk of gastric cancer development after eradication of Helicobacter pylori[J]. World journal of gastrointestinal oncology, 2018, 10(5): 115-123.

Shili L, Jianjian D, Xiang L, et al. Intestinal bacteria are potential biomarkers and therapeutic targets for gastric cancer[J]. Microbial Pathogenesis, 2021, 151104747-104747.

Jianing D, YanGao M, Xiaorong D, et al. Differences in community structure of gastrointestinal tract between Helicobacter pylori positive patients and negative patients with gastric cancer. [J]. Journal of Cancer, 2022, 13(6):1905-1913.

HanNa K, MinJeong K, P. J J, et al. Altered Gastric Microbiota and Inflammatory Cytokine Responses in Patients with Helicobacter pylori-Negative Gastric Cancer[J]. Nutrients, 2022, 14(23):4981-4981.

Prerna B, Joanna C, Ivonne L, et al. Microbiome Signatures in a Fast- and Slow-Progressing Gastric Cancer Murine Model and Their Contribution to Gastric Carcinogenesis[J]. Microorganisms, 2021, 9(1):189-189.

Silvia S, Irene M, Federica L, et al. Helicobacter pylori and Gastric Cancer: Pathogenetic Mechanisms[J]. International Journal of Molecular Sciences, 2023, 24(3): 2895-2895.

Wen C P, Jonathan J W L, Joy S C, et al. Mucosal microbiome associates with progression to gastric cancer[J]. Theranostics, 2022, 12(1):48-58.

Mirabella Z, Lóránt G, L P L, et al. The Burden of Inflammatory Bowel Disease in Europe in 2020[J]. Journal of Crohn's & colitis, 2021, 15(9):1573-1587.

Paula C, Paulina N, Pilar N, et al. Personalized therapy in inflammatory bowel disease[J]. Gastroenterologia y hepatologia, 2023, 47(7):763-770.

Pittayanon R, Lau T J, Leontiadis I G, et al.Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: A Systematic Review [J]. Gastroenterology, 2020, 158(4):930-946.e1.

Farré R, Fiorani M, Rahiman A S, et al. Intestinal Permeability, Inflammation and the Role of Nutrients [J]. Nutrients, 2020, 12(4):1185-1185.

Irene M, Silvia S, Vincenzo D, et al. Inflammatory cytokines: from discoveries to therapies in IBD[J]. Expert opinion on biological therapy, 2019, 19(11): 1207-1217.

Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: a cancer journal for clinicians, 2024, 74(3):229-263.

Si H, Yang Q, Hu H, et al. Colorectal cancer occurrence and treatment based on changes in intestinal flora[J]. Seminars in Cancer Biology, 2020, 7013-10.

Jie W J, R D P, Shreya A, et al. Association of distinct microbial signatures with premalignant colorectal adenomas. [J]. Cell host & microbe, 2023, 31(5): 827-838.e3.

Pang W S, Armon S, Chook B J, et al. Association of Fusobacterium nucleatum infection with the clinicopathological characteristics in colorectal cancer patients[J]. Molecular biology reports, 2024, 51(1): 124-124.

Ni W, JingYuan F. Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer[J]. Trends in microbiology, 2022, 31(2):

Xusheng Z, Dou Y, Di W, et al. Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance[J]. Cell Host & Microbe, 2023, 31(3): 418-432.e8.

Qingqing Z, Qing Z, Tao L, et al. Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity[J]. Cell metabolism, 2023, 35(6): 943-960.e9.

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Published

2024-09-26

How to Cite

Li, Y., & Wu, X. (2024). Research Progress on the Correlation between Gut Microorganisms and Gastrointestinal Diseases. Journal of Contemporary Medical Practice, 6(9), 149–152. https://doi.org/10.53469/jcmp.2024.06(09).27