Mechanisms of Action of the Herba Salviae Chinensis-Fructus Akebiae Pair in the Treatment of Non-small Cell Lung Cancer based on a Network Pharmacology Study

Authors

  • Guomin Dong Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Zhiyun Zhang Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Qian Ge Xi'an Medical University, Xi'an 710021, Shaanxi, China
  • Pengyu Han Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Jian Jiang Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Suoni Li Shaanxi Provincial Cancer Hospital, Xi'an 710000, Shaanxi, China
  • Jiequn Ma Shaanxi Provincial Cancer Hospital, Xi'an 710000, Shaanxi, China
  • Jie Bai Shaanxi Provincial Cancer Hospital, Xi'an 710000, Shaanxi, China
  • Yafen Qi Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China
  • Zheng Zhao Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China; Shaanxi Provincial Cancer Hospital, Xi'an 710000, Shaanxi, China

DOI:

https://doi.org/10.53469/jcmp.2024.06(09).24

Keywords:

Herba Salviae Chinensis, Fructus Akebiae, Non-small cell lung cancer, Network pharmacology

Abstract

Objective: To study the active ingredients and mechanism of action of "Herba Salviae Chinensis-Fructus Akebiae" drug pair in the treatment of non-small cell lung cancer (NSCLC) by using network pharmacology to provide theoretical basis for clinical application. Methods: The TCMSP (Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform) was used to obtain the active ingredients and targets of "Herba Salviae Chinensis-Fructus Akebiae", and the results were analyzed by the Genecard (https://genecard, org/) database, the Online Mendelian Inheritance Network (OMI), the Genecard database, the Genecard database, and the Online Mendelian Inheritance Network. We searched the Genecard (https://genecard, org/) database and the Online Mendelian Inheritance in Man (OMIM) database (http://omim. org/) for non-small cell lung cancer (NSCLC) disease targets by selecting "NSCLC" as a keyword, and then obtained the results of the "Herba Salviae Chinensis-Fructus Akebiae" drug pair by using venn. We used venn to obtain the intersecting targets of the drug pair "Herba Salviae Chinensis-Fructus Akebiae" and NSCLC, and then used the STRING database and Cytoscape to construct a common target visualization network diagram. The gene (GO) enrichment analysis and KEGG enrichment analysis were realized with the help of metascape database and Microbiology platform. Results: Five active ingredients of Ishiminokan-Precipitant were obtained, and 3695 non-small cell lung cancer targets and 123 common targets were obtained. GO analysis showed that the process of GO enrichment was mainly related to the regulation of responses to inorganic substances, transcriptional regulatory complexes, cytokine receptor binding, etc. KEGG enrichment showed that the process of KEGG enrichment was mainly through Pathways in Cancer, ILRT, and cytokine receptor binding. KEGG enrichment showed that KEGG mainly exerted anti-cancer effects through pathways in cancer and IL-17 signaling pathway. Conclusion: Using the method of network pharmacology, it is proved that the drug pair "Herba Salviae Chinensis-Fructus Akebiae" can exert therapeutic effects on NSCLC through multi-components, multi-targets, and multi-pathways, and provides the theoretical basis for the clinical application.

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Published

2024-09-26

How to Cite

Dong, G., Zhang, Z., Ge, Q., Han, P., Jiang, J., Li, S., … Zhao, Z. (2024). Mechanisms of Action of the Herba Salviae Chinensis-Fructus Akebiae Pair in the Treatment of Non-small Cell Lung Cancer based on a Network Pharmacology Study. Journal of Contemporary Medical Practice, 6(9), 123–130. https://doi.org/10.53469/jcmp.2024.06(09).24