Advances in the Study of the Mechanism of Gualou Xiebai Banxia Decoction in the Treatment of Coronary Heart Disease
DOI:
https://doi.org/10.53469/jcmp.2024.06(09).20Keywords:
Gualou Xiebai Banxia decoction, Coronary heart disease, Pharmacology, Mechanism of action, Clinical applicationAbstract
Gualou Xiebai Banxia Decoction (GXBD) is a commonly used formula for the clinical treatment of coronary heart disease, offering the advantages of wide clinical applicability and an outstanding therapeutic effect. In recent years, it has been demonstrated that Gualou Xiebai Banxia Decoction can improve the clinical symptoms of patients by correcting lipid metabolism disorders, slowing down the level of immuno-inflammation, resisting oxidative stress, improving energy metabolism, protecting endothelial cells, and promoting repair and regeneration of myocardial tissues. The objective of this paper is to present a review of the mechanism of treatment of coronary artery disease with Gualou Xiebai Banxia Decoction, with a view to providing a basis for the clinical application of this approach.
References
LIU Kaiwen, ZHANG Kui, ZHOU Ning, DONG Ran. Advancement in the relationship between gut microbiota and coronary artery disease[J]. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2023, 30(5):746-752.
WEI Yumiao, YU Liuyu. What is new in the management of coronary artery disease in 2020[J]. Journal of Clinical Cardiology, 2020, 36(7):591-593.
LIU Ming-bo, WANG Zeng-wu, FAN Jing, HU Sheng-shou. Key points of Report on Cardiovascular Health and Diseases in China 2023[J].Chinese Journal of Cardiovascular Research, 2024, 22(7):577-593.
NIU Puyu, LIU Yaoyuan, WANG Hanxiang, LIANG Benzhe, WANG Zeqing, ZHU Gengda, ZHAO Tieniu. Study on Distribution Characteristics of Traditional Chinese Medicine Syndromes in 207793 Patients with Coronary Heart Disease[J]. Chinese Medicine Modern Distance Education of China, 2021, 19(14):201-204.
ZHANG Ran, HAN Xu. Han Xu′s Experience of Treating Coronary Heart Disease from the Heart and Liver[J].Henan Traditional Chinese Medicine, 2024, 44(7):1061-1065.
Khatana C, Saini NK, Chakrabarti S, et al. Mechanistic insights into the oxidized low-density lipoprotein - induced atherosclerosis[J]. Oxid Med Cell Longev, 2020, 2020:5245308.
Tabas I, García-Cardena G, Owens GK. Recent insights into the cellular biology of atherosclerosi s[J]. J Cell Biol, 2015, 209(1):13.
YANG Qi, LIN Hui, WU Guoshui, MAO Ying, CHI Jufang, GUO Hangyuan. Evaluation of Gualou Xiebai Banxia decoction on vascular endothelial function in patients with coronary heart disease by Endo-PAT [J]. Journal of Electrocardiology and Circulation, 2021, 40(1):11-16.
GUO Jian-en, MI Shu-bin, YAN Xiu-chuan, XIN Si-yuan, GAO Fei, LIANG Guang-he, LI Jing-hua. Effects of Gualou Xiebai Banxia decoction on blood lipid content, oxidative stress and ox-LDL/Lox-1 pathway in ApoE-/- mice[J]. China Journal of Chinese Materia Medica, 2017, 42(4):752-757.
WANG Lei, GUAN Shuai, WU Meng-xue, ZHOU Hui, ZHAO Qi-tao, XUN Li-ying. Gualou Xiebai Banxia Decoction treats type 2 diabetes mellitus combined with acute myocardial infarction via chemerin/ CMKLR1/ PPARαsignaling pathway[J]. China Journal of Chinese Materia Medica, 2024, 49(6):1579-1586.
WENG Jinlong, XIONG Shangquan, JIANG Shu, ZHENG Feng, LIN Chao, ZHAO Li. Protective Effect and Mechanism of Pretreatment of Gualou Xiebai Banxia Decoction on Myocardial Ischemia-Reperfusion Injury Model Rats[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2023, 31(12):43-4853.
ZHU De-jian, WANG Qiang, MIAO Shi-rong, QIN Di, CHEN Qin-yue, HAN Yao-yao, CHEN Hao.The Influence of Trichosanthes and Chinese Chive and Pinellia Decoction on MMP-9 and TIMP-1 of Unstable Angina[J]. Henan Traditional Chinese Medicine, 2021, 41(3):357-360.
YANG Qi, LIN Hui, LYU Haitao. The effect of Chinese herbal formula Gualou Xiebai Banxia decoction on ventricular remodeling and inflammatory factors after acute myocardial infarction [J]. Journal of Electrocardiology and Circulation, 2020, 39(2):128-132.
GUO Jianen, GAO Fei, HU Yatao, WU Jinyang, ZHANG Shufeng, DONG Jiming, LI Jinghua. Effects of Gualou Xiebai Banxia Decoction on inflammatory cytokines and the expression of-1 ICAM and VCAM-1 in AS model mice[J]. Journal of Jinan University (Natural Science & Medicine Edition), 2017, 38(3): 234-239.
QIAO Wanning, CHEN Hongyin, ZHANG Yang. Oxidative stress and atherosclerosis[J]. Chinese Journal of Arteriosclerosis, 2023, 31(4):312-321.
ZHANG X, HUANG L F, HUA L, et al. Resveratrol protects myocardial apoptosis induced by ischemiareperfusion in rats with acute myocardial infarction via blocking P13K/Akt/e-NOS pathway[J]. Eur Rev Med Pharmacol Sci, 2019, 23(4):1789-1796.
QIU Weifeng, LUO Junqiang. Effect of modified Gualou Xiebai Banxia decoction and Ditan decoction on angina pectoris of coronary heart disease with phlegm-turbid obstruction type and its influences on oxidative stress indexes, ET-1, NO, cTnI and vWF levels[J]. Clinical Research and Practice, 2021, 6(29):1 50-152.
SUN Diyang, XUN Liying, ZHOU Jidong, YANG Yujie, WANG Lei, ZHAO Qitao. Gualou Xiebai Banxia decoction has a protective effect on typeⅡdiabetes mellitus complicated with acute myocardial ischemia by regulating the activation of PI3K/Akt/eNOS pathway by oxidative stress[J]. Journal of Xiamen University: Natural Science, 2023, 62(1):119-126.
ZHOU Man-li, YU Yun-feng, LUO Xiao-xin, LAN Xiao-dong, JIN Meng-yu, ZHANG Yi-fan, JIAN Wei-xiong. Mitochondrial Dynamics Mediates Myocardial Energy Metabolism in Coronary Heart Disease due to Blood Stasis[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2021, 27(21):80-90.
Chen W, Lv L, Nong Z, et al. Hyperbaric oxygen protects against myocardial ischemia reperfusion injury through inhibiting mitochondria dysfunction and autophagy [J]. Mol Med Rep, 2020, 22(5):4254.
TAN Yingying, WANG Hui, WANG Yanbing, LI Hong, MA Chengcheng, ZHANG Qi. Effect of Gualou Xiebai Banxiatang on Mitochondrial Dysfunction and AMPK/PGC-1α Signaling Pathway in Rats with Ischemic Myocardial Injury[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2023, 29(1):9-17.
LI Xiang, ZHANG Hua-min, CUI Hai-feng, SUI Yu, LI Ying-ying, TANG Dan-li.Effects of Gualou Xiebai Banxia Decoction on autophagy and PINK1/parkin pathway in rats with myocardial ischemia-reperfusion injury [J]. JOURNAL OF BASIC CHINESE MEDICINE, 2020, 26(11):1626-1630.
MA Xin, LI Yunlun. Study on the Pathological Basis of Blood Stasis Syndrome of Coronary Heart Disease from Vascular Endothelial Cell Injury[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2020, 0(1):117-120.
DING Zhuxin, ZHU Linping. Research progress on anti-atherosclerosis of Gualou Xiebai Banxia decoction [J]. China's Naturopathy, 2023, 31(6):114-117.
CHEN Wenhao, MENG Weishan, LI Hong, TIAN Weiwei, ZHANG Qi, TAN Yingying. Effect of Gualou Xiebai Banxiatang on Myocardial Microangiogenesis and HIF-1α/VEGF-related Pathways in Myocardial Ischemia Model Rats[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2024, 30(17):1-9.
Shen Zhongqi. Based on ALK1-LDL pathway to explore the mechanism of Gualou Xiebai Banxia Decoction in alleviatingox-LDL-induced vascular endothelial cell injur[D]. Shandong University of Traditional Chinese Medicine, 2021.
ZHANG Hongqiang, ZHANG Bing, LI Jianqi, JU Hailong. Mesenchymal stem cells for cardiac repair: opportunities and challenges[J]. Medical Research and Education, 2022, 39(5):25-30.
Wu Ming, Gao Yuping. Research Progress of Myocardial Reparation in Stem Cells[J]. Chinese Journal of Integrative Medicine on Cardio - Cerebrovascular Disease, 2016, 14(20):2383-2385.
XIAO W T, GUO S P, GAO C Y, et al. A randomized comparative study on the efficacy of intracoronary infusion of autologous bone marrow mononuclear cells and mesenchymal stem cells in patients with dilated cardiomyopathy[J]. Int Heart J, 2017, 58(2):238-244.
Ju X, Xue D, Wang T, et al. Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats[J]. Cardiovasc Toxicol, 2018, 18(5):471-481.
FU Yao, ZHOU Ji-dong, SANG Xiao-yu, SUN Di-yang, ZHAO Qi-tao, FU Feng-hua. Protective mechanism of Gualou Xiebai Banxia Decoction on hematopoietic stem cells in rats with type 2 diabetes complicated with acute myocardial ischemia[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2020, 35(5): 2613-2617.
ZHENG Mengmeng, ZHAO Qitao, ZHOU Jidong, FU Nini, HU Chaoqun, XUN Liying. The effect of Gualou Xiebai Banxia decoction on the mobilization of endothelial progenitor cells in rats of type 2 diabetes complicated with acute myocardial ischemia and its underlying mechanism[J]. Journal of Jinan University (Natural Science & Medicine Edition), 2018, 39(5): 435-441448.
Jiang Jingjing, Fu Nini, Sang Xiaoyu, Zheng Shuchen, Zhao Qitao. N-Butanol Fraction of Gualou Xiebai Banxia Decoction Inhibits Ischemia-Hypoxia-Induced Apoptosis of Bone Marrow Mesenchymal Stem Cells through PI3K/AKT Signaling Pathway[J]. Pharmacology and Clinics of Chinese Materia Medica, 2021, 37(4):2-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Xiaoyang Qiao, Qi Zhang
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.