Treatment of Gastroesophageal Reflux Disease Based on the Intestinal Flora Theory from Sweetness Reaches Spleen
DOI:
https://doi.org/10.53469/jcmp.2024.06(09).19Keywords:
Intestinal flora, Short chain fatty acids, Spleen and stomach, Plant polysaccharides, Gastroesophageal reflux diseaseAbstract
Context: Cases of gastroesophageal reflux disease (GERD) have shown an increasing trend over time, severely impacting patients' quality of life. Gut flora issues are a hot research topic, and their metabolites are strongly associated with host disease. Studies have shown that intestinal flora dysbiosis is not only related to diseases of the digestive system, but also has a certain connection with the endocrine system, nervous system and rheumatoid immune system. Recent national and international studies have shown a strong association between intestinal flora dysbiosis and GERD. Spleen-boosting herbs have also been found to help regulate the intestinal flora. The digestive system is synergized by the spleen and stomach of Chinese medicine and the intestinal flora; Purpose: Explore the connections between intestinal flora, TCM spleen and stomach, and GERD; Methods: Based on the pathomechanism of GERD, we will explore the mechanism of intestinal flora and its metabolites, the spleen and stomach of TCM, and the influence of TCM on related diseases to build a "hub" connecting TCM, intestinal flora, and GERD; Results: Through the anatomical structure and physiological properties of the digestive system, the scientific arguments related to the influence of intestinal flora on GERD through immunity and the central nervous system were constructed, which also revealed the importance of traditional Chinese medicine in regulating intestinal flora and influencing GERD; Conclusion: Herbal medicine can be used to treat GERD by regulating the intestinal flora. Dysbiosis of the intestinal flora influences the development of GERD through several pathways, The interconnection between spleen and stomach and flora in Chinese medicine and the effects of both on GERD were explored with the clue that sweetness reaches the spleen. It also provides a new therapeutic concept for the clinical treatment of GERD.
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