Research Progress on Regulation of Nrf2/Keap1 Signaling Pathway by Traditional Chinese Medicine in the Treatment of Diabetic Nephropathy
DOI:
https://doi.org/10.53469/jcmp.2024.06(09).08Keywords:
Diabetic nephropathy, Nrf2/Keap1, Oxidative stress, Inflammatory response, Traditional Chinese medicine monomer, Traditional chinese medicine decoctionAbstract
Diabetic kidney disease (DKD) is one of the more common microvascular diseases in diabetes, and its pathogenesis has not been fully revealed. Oxidative stress and inflammatory reaction play an important role in its pathogenesis. Studies have proved that the nuclear factor E2 related factor2(Nrf2)/Kelch like epichlorohydrin related protein-1 (Keap1) pathway is a signal pathway closely related to the occurrence and development of DKD, participating in the antioxidant stress and inflammatory response of the body, and is one of the important targets in the treatment of diabetes nephropathy. Some traditional Chinese medicine and related compound formulas can regulate the Nrf2/Keap1 signaling pathway to resist oxidative stress and anti-inflammatory effects, thereby improving renal function and delaying renal fibrosis, such as Tripterygium wilfordii glycosides, berberine, baicalin IV, icariin, resveratrol, emodin, curcumin, asiatica acid, tangshenning, compound asiatica, etc. Therefore, focusing on the composition and activation of the Nrf2/Keap1 signaling pathway, this paper summarizes the mechanism and current research progress of traditional Chinese medicine intervention in the treatment of DKD through the Nrf2/Keap1 signaling pathway, in order to provide new theoretical references for the prevention and treatment of DKD with traditional Chinese medicine and the development of new drugs.
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