Research Progress of Pharmacological Mechanism of Cistanche in the Treatment of Vascular Dementia
DOI:
https://doi.org/10.53469/jcmp.2024.06(09).04Keywords:
Cistanche, Vascular dementia, Pharmacological effect, Oxidative stressAbstract
Vascular dementia is one of clinical common type of dementia, its pathogenesis is complex, the incidence of rising trend year by year, the serious influence the patient's life and health. In the category of traditional Chinese medicine, vascular dementia belongs to the category of "dementia", and its etiology and pathogenesis are mostly related to "deficiency of kidney essence". Studies have found that Cistanche deserticola is a traditional Chinese medicine with a high frequency in the treatment of vascular dementia. It has the effects of toning kidney Yang, nourishing essence blood, moistening intestine and purging, and has definite advantages in preventing vascular dementia. C. deserticola chemical composition including echinacea glycosides, mullein indican, c. deserticola total glycosides, phenylethyl alcohol glycosides, flavonoids and polysaccharides, removal of oxygen free radicals and improve antioxidant compounds with resistance to oxidative stress; It plays an anti-vascular dementia role by clearing β-amyloid protein, reducing neuronal apoptosis, protecting hippocampal neurons, and regulating neurotransmitters to protect cholinergic nerves. This article reviews the pharmacological effects of cistanche deserticola on vascular dementia. As to provide theoretical basis for the use of c. deserticola and evidence-based support.
References
Wang Jiaxing, Nie Jiao. Progress in Traditional Chinese Medicine Research on Vascular Dementia [J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2023, 42 (02): 140-143. DOI:10.16040 /j.cnki.cn15-1101.2023.02.017.
Yu Wenxiao, Wang Yanjiang. Epidemiological Status and Development Trends of Vascular Cognitive Impairment in Asia [J]. Chinese Journal of Frontiers in Medicine (Electronic Edition), 2020, 12 (10): 1-8.
Li Qiang, Geng Xiuchao, Yu Wentao, et al. Literature study on the composition rules of vascular dementia prescriptions based on data mining [J]. Clinical Research of Traditional Chinese Medicine, 2018,10 (06): 34-37.
[4] Tu Pengfei, Jiang Yong. Re examination of the Materia Medica of Cistanche deserticola [J]. Chinese Journal of Traditional Chinese Medicine, 2022, 47 (20): 5670-5679 DOI: 10.19540/j.cnki. cjcmm.20220711.101.Fu Z, Fan X, Wang X, et al. Cistanches Herba: an overview of its chemistry, pharmacology, and pharmacokinetics property [J]. Journal of Ethnopharmacology, 2018, 219: 233-247.
Forman H J, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy [J]. Nature Reviews Drug Discovery, 2021, 20(9): 689-709.
Zhao R, Xu F, Xu X, et al. Effects of alpha-lipoic acid on spatial learning and memory, oxidative stress, and central cholinergic system in a rat model of vascular dementia [J]. Neuroscience letters, 2015, 587: 113-119.
Li Liang, Jiang Xiaofan, Li Xia, et al. Experimental study on the regulation of GSK3 β/Nrf2/ARE pathway by Cistanche deserticola phenylethanolic glycoside to alleviate oxidative stress injury in rats with middle cerebral artery infarction [J]. Shaanxi Medical Journal, 2023, 52 (06): 660-665.
Cui Bingbing, Li Ji, Zhu Juanjuan, et al. Research progress on the anti-aging mechanism of traditional Chinese medicine polysaccharides [J]. Grassroots Traditional Chinese Medicine, 2023, 2 (10): 143-148 DOI:10.20065/j.cnki.btcm.20230233.
Wang Xiaowen, Jiang Xiaoyan, Wu Liya Yiming, et al. In vitro clearance of free radicals and protective effect on DNA damage induced by OH · by total glycosides of Cistanche deserticola [J]. Chinese Journal of Pharmacy, 2001, (01): 29-32.
Wu Bo, Fu Yumei. Study on the anti lipid peroxidation effect of total glycosides of Cistanche deserticola on subacute aging mice [J]. Chinese Pharmacological Bulletin, 2005, (05): 639.
Meng Shengxi, Huo Qingping. Research progress on the effects of active ingredients in Cistanche deserticola on the nervous system [J]. Chinese Journal of Traditional Chinese Medicine Information, 2016, 23 (10): 123-126.
Cai Krei, Liu Zhixin, Sun Xiaodong, et al. Protective effects and mechanisms of polysaccharides from Cistanche deserticola on brain neurons in D-galactose-induced aging mice [J]. Chinese Journal of Gerontology, 2018, 38 (19): 4732-4734.
Jia J, Yan X, Cai Z, et al. The effects of phenylethanoid glycosides, derived from Herba cistanche, on cognitive deficits and antioxidant activities in male SAMP8 mice [J]. Journal of Toxicology and Environmental Health, Part A, 2017, 80(22): 1180-1186.
Jia J, Yan X, Song W, et al. The protective mechanism underlying phenylethanoid glycosides (PHG) actions on synaptic plasticity in rat Alzheimer’s disease model induced by beta amyloid 1-42 [J]. Journal of Toxicology and Environmental Health, Part A, 2018, 81(21): 1098-1107.
Zhu K, Meng Z, Tian Y, et al. Hypoglycemic and hypolipidemic effects of total glycosides of Cistanche tubulosa in diet/streptozotocin-induced diabetic rats [J]. Journal of ethnopharmacology, 2021, 276: 113991.
Wu C R, Lin H C, Su M H. Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer’s disease-like rat model: relevance for amyloid deposition and central neurotransmitter function [J]. BMC complementary and alternative medicine, 2014, 14: 1-11.
Roland, Wang Xiaowen, Shi Kourong, et al. Preliminary study on the effect of total glycosides of Cistanche deserticola on the pathological morphology of hippocampal CA1 region in experimental AD rats induced by β - amyloid protein [J]. Journal of North Sichuan Medical College, 2020, 35 (06): 947-951.
Li Guangzong, Li Jing, Zhu Chen, et al. Risk factors for vascular dementia after cerebral infarction and early predictive value of serum VEGF and MMP-9 [J]. Journal of Integrated Traditional Chinese and Western Medicine in Cardiovascular and Cerebrovascular Diseases, 2021, 19 (05): 836-839.
Xie Qian. Protective effect of total glycosides of Cistanche deserticola on lipopolysaccharide induced inflammation in microglia [D]. Xinjiang Medical University, 2021 DOI:10.27433/d.cnki.gxyku.2021.000819.
Xing Haiyan. Molecular mechanism of Mongolian medicine Cistanche deserticola and verbascoside promoting neurotransmitter acetylcholine release [D]. Inner Mongolia Medical University, 2020. DOI: 10.27231/d.cnki.gnmyc.2020.000492
Liu Zhiqin, Chen Queting, Li Yan, et al. Effects of Cistanche deserticola on hematopoietic and immune function in chemotherapy induced tumor bearing mice [J]. Journal of Beijing University of Traditional Chinese Medicine, 2010,33 (11): 758-761.
Wang Fujiang, Tu Pengfei, Zeng Kewu, et al. Study on the protective effect of total glycosides of Cistanche deserticola on alcoholic liver injury in mice [J]. Acta Pharmaceutica Sinica, 2021, 56 (09): 2528-2535. DOI: 10.16438/j.0513-4870.2020-1563.
Shuping, Zhao Jun, Mukremu Tudimaiti, et al. Effects of phenylethanoid glycosides from Cistanche deserticola on the expression of transforming growth factor β 1 in BSA induced liver fibrosis rats [J]. Carcinogenesis, Aberration, and Mutation, 2015, 27 (06): 409-414.
Zhang Yuequan, Zheng Danhong, Xu Jianfeng, et al. Effects of Desert Cistanche on BMP-2 Protein Expression in Rapidly Aging Osteoporosis Mice [J]. Ningxia Medical Journal, 2014, 36 (12): 1114-1116. DOI: 10.13621/j. 1001-5949.2014.12.1114.
Yang L, Zhang X, Liao M, et al. RETRACTED: Echinacoside improves diabetic liver injury by regulating the AMPK/SIRT1 signaling pathway in db/db mice [J]. 2021.
Zhu K, Meng Z, Tian Y, et al. Hypoglycemic and hypolipidemic effects of total glycosides of Cistanche tubulosa in diet/streptozotocin-induced diabetic rats [J]. Journal of ethnopharmacology, 2021, 276: 113991.
Zhao Donghai, Zhang Lei, Zhang Yan, et al. The therapeutic effect and mechanism of Cistanche deserticola phenylethanolic glycoside on cyclophosphamide induced spermatogenic disorders in mice [J]. Journal of Jilin University (Medical Edition), 2014, 40 (03): 612-615. DOI:10.13481/j. 1671 -587x.20140330.
Fan Yanan, Huang Yuqiu, Jia Tianzhu, et al. The catharsis effect of Cistanche deserticola on constipation rats before and after processing [J]. traditional Chinese patent medicines and simple preparations, 2016, 38 (12): 2684-2687.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Huiwen Yang, Zhiqiang Hao, Feng Miao
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.