Advancements in the Research of Therapeutic Mechanisms of Kidney-Nourishing Approach for Premature Ovarian Failure
DOI:
https://doi.org/10.53469/jcmp.2024.06(06).38Keywords:
Premature ovarian failure, Traditional Chinese Medicine, Kidney-tonifying methods, Mechanism of actionAbstract
Premature ovarian failure (POF) is a prevalent condition that significantly impairs the quality of life for women during their reproductive years. Its implications for patients and their daily routines are profound, and the disease's chronic progression can even trigger a range of other systemic ailments. In recent years, numerous studies have highlighted the reduced toxicity and side effects of Traditional Chinese Medicine (TCM) in treating POF, along with its notable therapeutic effects. TCM holds that the kidney governs reproduction, and a robust kidney essence leads to strong reproductive function. The kidney-produced "Tiangui" directly oversees menstruation. As such, the approach of nourishing the kidney and regulating menstruation in treating POF is grounded in solid theory and rich practical experience. This paper, from the perspective of kidney nourishment in TCM, reviews relevant research both domestically and internationally on how TCM's kidney-nourishing prescriptions improve POF. It also summarizes the mechanisms involved, aiming to provide valuable insights for clinical efficacy and treatment strategies for POF.
References
Feng Xiaoling, Li Li, Qu Fan, et al. Guideline for the Diagnosis and Treatment of Premature Ovarian Insufficiency with Integrated Traditional Chinese and Western Medicine [J]. Journal of Traditional Chinese Medicine, 2022, 63: 1193-8.
EUROPEAN SOCIETY FOR HUMAN R, EMBRYOLOGY GUIDELINE GROUP ON P O I, WEBBER L, et al. ESHRE Guideline: management of women with premature ovarian insufficiency [J]. Human Reproduction (Oxford, England), 2016, 31(5): 926-37.
TORREALDAY S, KODAMAN P, PAL L. Premature Ovarian Insufficiency-an update on recent advances in understanding and management [J]. F1000Research, 2017, 6: F1000 Faculty Rev-2069.
Wang Shimeng, Zhao Xiaoxuan, Zhang Yang, et al. Interpretation of diagnosis and Treatment of Integrated Traditional Chinese and Western Medicine [J]. Chinese Journal For Clinicians, 2022, 50: 899-903.
Menopause group of Obstetrics and Gynecology Branch of Chinese Medical Association. Expert consensus on hormonal supplementation therapy for early-onset ovarian insufficiency[J]. Chinese Journal of Obstetrics and Gynecology, 2016, 51(12): 881-6.
LI Juan, XU Lin, GAO Yang. Research progress and status quo of pathogenesis and treatment of premature ovarian failure [J]. China Medicine And Pharmacy 2021, 11(02): 58-61.
Tian Daihua school note. Huangdi neijing asked the notes [M]. The People's Military Medical Publishing House, 2011.
Tian Daihua, Liu Gengsheng finishing, Liu Gengsheng. Lingshu Jing, Miraculous Pivot [M]. The People's Health Publishing House, 2005.
Yu Tuan. Medical biography [M]. The People's Health Publishing House, 1981.
Zhang Xuan, Xing Tianlin, He Xinyi. Professor Jin Zhe's experience in in vitro fertilization in the treatment of ovarian dysfunction [J]. Hebei Journal of Traditional Chinese Medicine, 2014, 36: 1445-7.
Fu Shan. Fu Qingzhu [M]. The People's Military Medical Publishing House, 2007.
Zhong Fengjiao, Zhao Guangxing. "Fu Qing master female ke" "through the water out of the kidney" academic thought [J]. Forum On Traditional Chinese Medicine, 2006: 14-5.
Zhang Jingyue. Jingyue Encyclopedia: Women's rules [M]. Beijing: China Medical Science and Technology Press, 2017.
HAN Yanhua; QI Na; FENG Cong. Summary of Longjiang Han′s Experience in Gynecology in Treatment of Premature Ovarian Insufficiency [J]. Acta Chinese Medicine, 2021, 36: 328-32.
WANG Ge,HAN Yanhua. Longjiang HAN’s Gynecology’s Experience in Treating Premature Ovarian Insufficiency [J]. Journal of Zhejiang Chinese Medical University, 2022, 46: 982-5.
Lu Kena, Chen Huineng Nong. Chen Huineng's treatment of early onset ovarian insufficiency [J]. Lishizhen Medicine and Materia Medica Research, 2020, 31: 2523-4.
Cui Xiaoping, Chen Rui, Zhang Qin, et al. Clinical study ideas of Yin-Yang sequential therapy to improve ovarian reserve function in the early stage of premature ovarian failure [J]. Shaanxi Journal of Traditional Chinese Medicine, 2010, 31: 198-9.
YAN Qingya, LU Yiqin, XIAO Chengzong. TCM master Xiao Chengzong’s experience in treating infertility due to premature ovarian failure [J]. Modern Chinese Clinical Medicine, 2023, 30: 10-5.
Zhang Fengfeng, Cui Xiaoping, Zhao Panting, et al. Chief Physician Cui Xiaoping′s Experience in Treating Premature Ovarian Failure [J]. Western Journal of Traditional Chinese Medicine, 2022, 35: 48-51.
JIANG M, WANG W, ZHANG J, et al. Protective effects and possible mechanisms of actions of Bushen Cuyun recipe on diminished ovarian reserve induced by cyclophosphamide in rats [J]. Frontiers in Pharmacology, 2020, 11: 546.
Zhao Jingying, Wang Juan, Xiao Min, et al. Experimental study of Bushen Huoxue Decoction Regulating Reproductive Hormone Level in Rats with Reduced Ovarian Reserve Function [J]. Journal of Hunan University of Chinese Medicine, 2021, 41: 1031-6.
Zhu Jingru, Chen Shuting, Zhuo Zewei, et al. Effect of Bushen Jianpi Recipe on Hypothalamic-pituitary-gonad Axis Function in Rats with Premature Ovarian Failure [J]. Fujian Journal of Traditional Chinese Medicine, 2021, 52: 14-7.
Wang Yang, Chen Shuting, Zhu Jingru, et al. Effect of Soothing Liver and Tonifying Kidney Method on Hypothalamus-Pituitary-Ovary Axis in Premature Ovarian Failure Rats [J]. Fujian Journal of Traditional Chinese Medicine, 2021, 52: 25-6+35.
YAN Fengle, LIU Rong. Analysis of the Regulatory Mechanism of Bushen Cupailuan Decoction on Hypothalamus-Pituitary-Ovary Axis Based on the Rat Model of Polycystic Ovary Syndrome [J]. New Chinese Medicine, 2023, 55: 13-7.
Zhao Fanqin, Zhao Yan, Liu Jieying, et al. Effects of Zuogui Pill on Expressions of FSHR, LHR and ER of HPO in POF Rats and Early-Aging Rats[J]. Acta Chinese Medicine and Pharmacology, 2022, 50: 25-31.
Zhao Fanqin, Zhao Yan, Liu Jieying, et al. Effect of Zuogui Wan(左归丸) on estrogen receptor expression in hypothalamus, pituitary and ovarian tissue of premature ovarian failure (POF) model and primary senescence rats [J]. Journal of Gansu University of Chinese Medicine, 2022, 39: 1-8.
Zeng Lihua, Zhang Yingxuan, Liang Yunyi, et al. Serum Metabolomics Studies on Zuogui Pills in the Treatment of Premature Ovarian Insufficiency Rats Based on UPLC-Q-TOF-MS [J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2022, 33: 762-9.
Zhang Zhaoping, Zeng Lihua, Liang Yunyi, et al. Effect of Zuogui Pills on the Notch Signaling Pathway in Ovarian Tissue of Rats with Premature Ovarian Insufficiency[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2022, 39: 1609-15.
Ma Kun, Li Jiani, Fan Xiaodi, et al. Mechanism of kidney-tonifying and blood-activating therapy for premature ovarian failure:a review [J]. China Journal of Chinese Materia Medica, 2023, 48: 1808-14.
CAI Binbin, Wang Suxia, Zhu Yutian, and so on. Effects of Yulin Formula on ultra structure ofovarian granulosa cells in diminished ovarian reserve rats [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2020, 35: 3074-7.
Chen Yanxia. The mechanism of PI3K and Nrf 2 signaling pathway protecting ovarian reserve [D]. China Academy of Chinese Medical Sciences, 2020.
Yan Ruen, Qiu Hua, He Jing, et al. Effect of kidney modulation on apoptosis of granulosa cells in rats with reduced ovarian reserve [J]. Chinese Traditional Patent Medicine, 2022, 44: 1955-60.
KUN M, YUAN Y, YANXIA C, et al. Efficacy of Bushen Culuan decoction on ovarian follicle and follicular granulosa cells in mice with premature ovarian insufficiency induced by tripterygium wilfordii polyglycoside [J]. Journal of Traditional Chinese Medicine, 2022, 42(01): 23-9.
Xiao Xiao, Liu Yanxia, Wei Yifei, and so on. Effects of Yishen Shugan Decoction on Apoptosis of Ovarian Granulosa Cells in Rats with Diminished Ovarian Reserve [J]. Chinese Journal of Information on Traditional Chinese Medicine, 2023, 30: 85-90.
Yan Rugen, Qi Fanghua, He Jing, et al. Effect of Yishen Tiaojing Prescription on PTEN/PI3K/AKT Signaling Pathway in Ovarian Tissue of Rats with Decreased Ovarian Reserve [J]. Journal of Chinese Medicinal Materials, 2022: 1723-9.
Xiao Xiao, Liu Yanxia, Wei Yifei, and so on. Effect of Yishen Shugan Decoction-containing Serum on Apoptosis of Granulosa Cells in Rats Treated with Tripterygium wilfordii Glycosides[J]. World Chinese Medicine, 2022, 17: 3148-53.
CHAIKUAD A, BULLOCK A N. Structural basis of intracellular TGF-β signaling: receptors and smads [J]. Cold Spring Harbor perspectives in biology, 2016, 8(11): a022111.
Wang Chunxia, Yue Shi Shi, MAO Yijia, et al. Study of the effect of kidney tonifying and gestation promoting decoction on rat ovarian granulosa cells Smad3 and Smad4 [J]. China Modern Doctor, 2020, 58: 40-3.
Zhang Fang, Ding Yi, Yu Xiao, et al. Mechanism of Bushen Yangjing Granule (补肾养精颗粒) in Regulating Apoptosis of Ovarian Granulosa Cell in Model Rats with Premature Ovarian Insufficiency [J]. Journal of Shandong University of Traditional Chinese Medicine, 2022, 46: 365-72+78.
Yu Xiao, Wang Yuchao, Liu Jinxing, et al. Inhibitory effect of Bushen Yangjing granule on apoptosis of ovarian granulosa cells in rats with premature ovarian insufficiency and its mechanism [J]. Shandong Medical Journal, 2022, 62: 12-6.
Chen Qiong, Jin Yuli, Hang far away, and so on. Effects of Yushen Zhuyun decoction on activation of ERK1/2 and JNK1/2 proteins in ovarian granulosa cells of rats with diminished ovarian reserve [J]. Shaanxi Journal of Traditional Chinese Medicine, 2022, 43: 411-5.
He Xin, Wang Tong, Ma Yanmin. The damage effect of oxidative stress on female reproductive system [J]. Chinese Journal of Birth Health & Heredity, 2017, 25: 1-2+104.
AGARWAL A, GUPTA S, SEKHON L, et al. Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications [J]. Antioxidants redox signaling, 2008, 10(8): 1375-404.
AITKEN R J J R. Impact of oxidative stress on male and female germ cells: implications for fertility [J]. 2020, 159(4): R189-R201.
Yan Jing, Ma Mona, Zhao Jiyu, et al. Effect of "Zhibian" (BL 54)-to-"Shuidao" (ST 28) needle insertion on the expression of Fas/FADD/Caspase-8 of death receptor pathway in rats with primary ovarian insufficiency [J]. Chinese Acupuncture & Moxibustion, 2023, 43: 537-44.
Guo Dongyan, Zhou Hua, Fan Yu, et al. Experimental study on protective effect and mechanism of Shengdihuang Decoction on ovary of rats with premature ovarian failure [J]. China Journal of Chinese Materia Medica, 2019, 44: 4698-703.
Zhang Yan. Clinical study on tonifying kidney and promoting blood circulation and improving low ovarian reserve function in patients with kidney deficiency and blood stasis [D]. Nanjing University of Chinese Medicine, 2020.
MA Y-C, HAO G-M, ZHAO Z-M, et al. Effects of Bushen-Tiaojing-Fang on the pregnancy outcomes of infertile patients with repeated controlled ovarian stimulation [J]. Scientific Reports, 2021, 11(1): 1-12.
Chen Si. Clinical studies on improving early-onset ovarian insufficiency and the mechanism of Keap 1 / Nrf 2 / ARE signaling pathway in regulatory model mice [D]. Nanjing University of Chinese Medicine, 2021.
ZHAO Y, CHEN Y, MIAO C, et al. He’s Yangchao Recipe Ameliorates Ovarian Oxidative Stress of Aging Mice under Consecutive Superovulation Involving JNK-And P53-Related Mechanism [J]. Evidence-Based Complementary Alternative Medicine, 2022, 2022.
Zhong Xunlong, Xu Wei, Liang Wenyi, et al. Effect of two-to-bolus on H_2O_2-induced oxidative stress damage in INS-1 islet β -cells [J]. New Chinese drugs and clinical pharmacology, 2020, 31: 1008-14.
Liu Qinan, Xu Jia, Zhai Yuanyuan, et al. The Protective Function of Erzhiwan on D-galactose-Induced Senescence in Normal Rat Kidney Cells [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2018, 34: 81-6.
Chen Guiping, Chen Xiulian, Wu Qiannan. To explore the influence of uterine ovarian blood flow index after kidney tonic TCM intervention in patients with low ovarian reserve [J]. World's latest medical information abstract, 2017, 17: 138+40.
Yang Zhen, Feng Xunxun, Dong Xiaoying. Mechanism of Yulinzhu’s prevention and treatment of premature ovarian insufficiency by improving ovarian microenvironment in mice [J]. Journal of Reproductive Medicine, 2020, 29: 231-7.
XU X, TAN Y, JIANG G, et al. Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure [J]. Chinese Medicine, 2017, 12: 1-11.
Yin Yan, Jin Zhichun, Yang Yaqin, et al. Effect of Bushen Yiqi Hexue Decoction on serum sex hormone and expression of VEGF and its receptor protein in ovarian tissue of rats with decreased ovarian reserve [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2021, 30: 1830-5+9.
Li LAN, He Bing, Dai Yue. Effect of beneficial renal menstrual regulation on endometrial receptivity and hormone levels in patients with premature ovarian failure [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2023, 32: 368-72.
Tang Liming. Left gui bolus promotes the relationship between genital angiogenesis and PL GF, HGF and its receptors [D]. Medical University Of Chongqing, 2022.
Wei Xiaojing. The relationship between ovarian angiogenesis and CXCL 8-CXCR 1/2 pathway and Ang1 and 2 in rats [D]. Medical University Of Chongqing, 2022.
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