Mechanism of Main Extracts from Eucommia Ulmoides Against Osteoporosis based on the Gut-bone Axis Theory

Abstract

Osteoporosis (OP) is a disease characterized by reduced bone mass and deterioration of bone tissue microstructure, leading to increased bone fragility and fracture risk. Its pathogenesis is complex and not yet fully understood [1]. The “gut-bone axis” theory reveals the bidirectional regulation between the intestinal microbiota and the skeletal system, which is highly consistent with the pharmacological effects of Eucommia ulmoides. This article systematically summarizes the research progress of the main active components of Eucommia ulmoides and their prevention and treatment of OP, and reviews from two aspects: the correlation between the “gut-bone axis” and OP, and the mechanism of action of the main active components of Eucommia ulmoides in regulating the "gut-bone axis", with the aim of providing theoretical references for in-depth research and clinical application of Eucommia ulmoides in the field of osteoporosis prevention and treatment.