Research Progress on the Regulation of Macrophage Polarization by Traditional Chinese Medicine in the Prevention and Treatment of Immune Injury in Diabetic Nephropathy

Abstract

Diabetic nephropathy (DN) is one of the serious microvascular complications of diabetes, which is mainly caused by non-enzymatic glycosylation of the basement membrane of blood vessels, which in turn leads to microvascular damage, which will rapidly develop into chronic renal failure if not treated in time, and immune damage plays an important role in its pathogenesis. Macrophage polarization plays a key role in the immune inflammatory response in diabetic nephropathy. In recent years, some progress has been made in the research on the regulation of macrophage polarization by traditional Chinese medicine in the prevention and treatment of immune injury in diabetic nephropathy. This article reviews the relationship between macrophage polarization and immune damage in diabetic nephropathy, the mechanism of TCM regulation of macrophage polarization, and the clinical application prospects.