The Significance of TLG Load Characterization in PET / CT Interpretation of Patients with Osteogenic Bone Metastasis of Prostate Cancer

Abstract

Objective: To investigate the application value of total tumor load (TLG) load characterization in PET / CT interpretation of patients with osteogenic bone metastasis of prostate cancer and its significance in efficacy evaluation. Methods: From January 2025 to December 2025,96 patients with osteogenic bone metastasis of prostate cancer diagnosed by pathology and imaging were selected and divided into study group and control group according to whether TLG load characterization analysis was performed. TLG quantitative analysis was performed in the study group on the basis of PET / CT examination, and the control group was evaluated by conventional imaging. The TLG value, the number of bone metastasis lesions and the changes of TLG before and after treatment were compared between the two groups. All patients received standardized treatment, and the efficacy was evaluated in combination with the clinical research standard for prostate cancer (PCWG3). Results: There was no significant difference in TLG value and the number of bone metastases between the two groups before treatment (P > 0.05). After treatment, the TLG value of the study group was significantly lower than that of the control group, and the number of bone metastases was significantly reduced, the difference was statistically significant (P < 0.05). At the same time, the changes of TLG in the study group before and after treatment were significantly greater than those in the control group, suggesting that TLG load characterization has higher sensitivity in reflecting tumor metabolic changes and lesion load dynamics. The change of TLG in the control group was not obvious, indicating that the traditional imaging evaluation had certain limitations at the metabolic level. Conclusion: TLG load characterization can integrate tumor metabolic activity and volume information, and has high application value in PET / CT interpretation of patients with osteogenic bone metastasis of prostate cancer. It can effectively reflect the change of tumor load, improve the accuracy and sensitivity of efficacy evaluation, and provide an important basis for clinical formulation of individualized treatment plan, which has a good clinical promotion prospect.