Pigment Epithelium - Derived Factor (PEDF) as an Early Marker of Reproductive Aging in Female - A Crossectional Study

Abstract

Reproductive aging is a biological phenomenon that is seen in women, noted by a progressive decline in ovarian function and a decrease in both the quantity and quality of oocytes by changes at the molecular level. Studies have shown that the pigment epithelium - derived factor (PEDF) plays a crucial role in maintaining ovarian angiogenic, and inflammatory and oxidative balance. Thus, an exploration of the involvement of PEDF with ovarian aging is necessary to gain a deeper knowledge of the mechanism which depicts the decreasing ovarian function and the deterioration of oocyte quantity and quality during the mid - 30s to 40s of a woman's life. The evaluation of PEDF in reproductive aging holds promise for advancing our knowledge of the factors and possible signal cascade that change ovarian health which eventually leads to ovarian aging. It may also provide valuable insights into potential therapeutic strategies or interventions that could help to solve female fertility - related problems due to the global trend in late - age childbearing. In this review we are debating whether PEDF could be a potential candidate for an early marker to detect reproductive aging; also, we relate oxidative stress (OS) with reproductive aging and the possible role of PEDF in it.