Exploring Acute High-Altitude Hypoxic Myocardial Injury from the Perspective of Mitochondrial Quality Control

Abstract

Acute high-altitude hypoxic exposure-induced myocardial injury poses a serious threat to the health of populations in high-altitude areas. Clinically, it primarily manifests as chest tightness, palpitations, shortness of breath, arrhythmias, and abnormal myocardial enzyme profiles. In severe cases, it can present as congestive heart failure. The main cause lies in the disruption of the mitochondrial quality control system under hypoxic conditions, leading to damage to mitochondrial structure and function. Therefore, this paper aims to systematically introduce the mitochondrial quality control system, elucidate the mechanisms of mitochondrial quality control imbalance during acute high-altitude hypoxia and its correlation with myocardial injury, and explore related treatment interventions in both traditional Chinese medicine and Western medicine.