The Role of Oxidative Stress in Liver Fibrosis and Advances in Antioxidant Therapy Using Natural Products

Abstract

The correlation between oxidative stress and liver fibrosis has garnered extensive attention from scholars worldwide. Research indicates that oxidative stress may be a key factor in the onset and progression of liver fibrosis. Given the complex array of oxidative stress-related genes and pathways, recent studies targeting specific pathways have demonstrated therapeutic potential for liver fibrosis using certain drugs. This review will summarize the mechanisms by which oxidative stress influences liver fibrosis. It will also compile recent research progress on various natural product antioxidants targeting oxidative stress for liver fibrosis treatment, aiming to provide more effective strategies for the prevention and management of liver fibrosis.